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• W2962979 startingPage "991" @default.
• W2962979 abstract "The Ewing family of tumors (Ewing's sarcoma and primitive neuroectodermal tumor [PNET]) is the second most common malignant bone tumor (after osteogenic sarcoma) in children and adolescents. These tumors can also occur in soft tissue, presenting in a manner similar to rhabdomyosarcoma. Nearly half of all patients with Ewing's family tumors are between 10 and 20 years of age, and 70% are under the age of 20, with a slight male predominance. The annual incidence in the United States is 2.1 cases per million children.81 A similar incidence of these tumors occurs throughout the world in countries composed mostly of whites or persons of Hispanic origin; however, these tumors are extremely rare in black children and children of Asian origin.15, 36 The reason for this striking difference in incidence according to racial background is unknown. Ewing's tumor was originally described in 1921 by James Ewing as an endothelioma.14 Over the past decade it has become clear that Ewing's sarcoma, in fact, derives from a primitive neuroectodermal cell with variable differentiation. Classical Ewing's sarcoma is a poorly differentiated small round blue cell tumor, whereas, on the other end of the scale, PNET shows quite discernible differentiation. Both share the same histochemical staining profile and a unique characteristic translocation t(11;22) or a variation of the same within the tumor cell. Virtually all Ewing's tumors contain the chromosomal marker." @default.
• W2962979 created "2016-06-24" @default.
• W2962979 creator A5011956202 @default.
• W2962979 date "1997-08-01" @default.
• W2962979 modified "2023-10-03" @default.
• W2962979 title "THE EWING FAMILY OF TUMORS" @default.
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• W2962979 doi "https://doi.org/10.1016/s0031-3955(05)70541-1" @default.
• W2962979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9286296" @default.
• W2962979 hasPublicationYear "1997" @default.
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