FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963008092> ?p ?o ?g. }

• W2963008092 abstract "ABSTRACT Sarcoptic mange is a highly contagious skin disease caused by the ectoparasitic mite, Sarcoptes scabiei . Although it afflicts over 100 mammal species worldwide, sarcoptic mange remains a disease obscured by variability at the individual, population, and species levels. Amid this variability, it is critical to identify consistent drivers of morbidity, particularly at the skin barrier. We characterized the skin microbiome of three species of North American canids: coyotes ( Canis latrans ), red foxes ( Vulpes vulpes ), and gray foxes ( Urocyon cinereoargenteus ). Comparing mange-infected and uninfected individuals, we found remarkably consistent signatures of microbial dysbiosis associated with mange infection. Across genera, mange-infected canids exhibited reduced microbial diversity, altered community composition, and increased abundance of opportunistic pathogens. The primary bacteria comprising these secondary infections were Staphylococcus pseudintermedius , previously associated with canid ear and skin infections, and Corynebacterium spp , previously found among the gut flora of S. scabiei mites and hematophagous arthropods. Considered together, this evidence suggests that mange infection consistently alters the canid skin microbiome and facilitates secondary bacterial infection. These results provide valuable insights into the pathogenesis of mange at the skin barrier of North American canids and can inspire novel treatment strategies. By further adopting a “One Health” framework that considers mites, microbes, and the potential for interspecies transmission, we can better elucidate the patterns and processes underlying this ubiquitous and enigmatic disease." @default.
• W2963008092 created "2019-07-30" @default.
• W2963008092 creator A5006208407 @default.
• W2963008092 creator A5015824236 @default.
• W2963008092 creator A5072519971 @default.
• W2963008092 date "2019-07-22" @default.
• W2963008092 modified "2023-09-23" @default.
• W2963008092 title "Of Microbes and Mange: Consistent changes in the skin microbiome of three canid species infected with sarcoptic mange" @default.
• W2963008092 cites W1565678675 @default.
• W2963008092 cites W1593220458 @default.
• W2963008092 cites W1600919011 @default.
• W2963008092 cites W1735389067 @default.
• W2963008092 cites W1917694478 @default.
• W2963008092 cites W1979157623 @default.
• W2963008092 cites W1985307471 @default.
• W2963008092 cites W1985662139 @default.
• W2963008092 cites W1986579933 @default.
• W2963008092 cites W1988925586 @default.
• W2963008092 cites W1994262267 @default.
• W2963008092 cites W2002893301 @default.
• W2963008092 cites W2011518291 @default.
• W2963008092 cites W2017886942 @default.
• W2963008092 cites W2022961189 @default.
• W2963008092 cites W2034652863 @default.
• W2963008092 cites W2037327330 @default.
• W2963008092 cites W2045249765 @default.
• W2963008092 cites W2072970694 @default.
• W2963008092 cites W2080283023 @default.
• W2963008092 cites W2082186854 @default.
• W2963008092 cites W2083052623 @default.
• W2963008092 cites W2083926999 @default.
• W2963008092 cites W2084057318 @default.
• W2963008092 cites W2085461453 @default.
• W2963008092 cites W2098383110 @default.
• W2963008092 cites W2101382631 @default.
• W2963008092 cites W2104052458 @default.
• W2963008092 cites W2108538550 @default.
• W2963008092 cites W2110067767 @default.
• W2963008092 cites W2113831600 @default.
• W2963008092 cites W2122674341 @default.
• W2963008092 cites W2130371694 @default.
• W2963008092 cites W2133735153 @default.
• W2963008092 cites W2134460424 @default.
• W2963008092 cites W2134561148 @default.
• W2963008092 cites W2146663481 @default.
• W2963008092 cites W2151911433 @default.
• W2963008092 cites W2168249366 @default.
• W2963008092 cites W2168512514 @default.
• W2963008092 cites W2173707956 @default.
• W2963008092 cites W2258876911 @default.
• W2963008092 cites W2336330109 @default.
• W2963008092 cites W2401404581 @default.
• W2963008092 cites W2410050274 @default.
• W2963008092 cites W2463836225 @default.
• W2963008092 cites W2513506562 @default.
• W2963008092 cites W2528524934 @default.
• W2963008092 cites W2573450200 @default.
• W2963008092 cites W2587681257 @default.
• W2963008092 cites W2591555463 @default.
• W2963008092 cites W2622731166 @default.
• W2963008092 cites W2674126249 @default.
• W2963008092 cites W2778026792 @default.
• W2963008092 cites W2787902098 @default.
• W2963008092 cites W2791536363 @default.
• W2963008092 cites W2807194798 @default.
• W2963008092 cites W2887564303 @default.
• W2963008092 cites W2908580553 @default.
• W2963008092 cites W2911841234 @default.
• W2963008092 cites W2913372117 @default.
• W2963008092 cites W2917207851 @default.
• W2963008092 cites W2921954850 @default.
• W2963008092 cites W4236236547 @default.
• W2963008092 cites W4242702784 @default.
• W2963008092 doi "https://doi.org/10.1101/709436" @default.
• W2963008092 hasPublicationYear "2019" @default.
• W2963008092 type Work @default.
• W2963008092 sameAs 2963008092 @default.
• W2963008092 citedByCount "0" @default.
• W2963008092 crossrefType "posted-content" @default.
• W2963008092 hasAuthorship W2963008092A5006208407 @default.
• W2963008092 hasAuthorship W2963008092A5015824236 @default.
• W2963008092 hasAuthorship W2963008092A5072519971 @default.
• W2963008092 hasBestOaLocation W29630080921 @default.
• W2963008092 hasConcept C143121216 @default.
• W2963008092 hasConcept C16005928 @default.
• W2963008092 hasConcept C188382862 @default.
• W2963008092 hasConcept C18903297 @default.
• W2963008092 hasConcept C2776082042 @default.
• W2963008092 hasConcept C2776599699 @default.
• W2963008092 hasConcept C2779557943 @default.
• W2963008092 hasConcept C2779711295 @default.
• W2963008092 hasConcept C2780968714 @default.
• W2963008092 hasConcept C2781443149 @default.
• W2963008092 hasConcept C2908647359 @default.
• W2963008092 hasConcept C42972112 @default.
• W2963008092 hasConcept C60644358 @default.
• W2963008092 hasConcept C71924100 @default.
• W2963008092 hasConcept C86803240 @default.
• W2963008092 hasConcept C90856448 @default.
• W2963008092 hasConcept C99454951 @default.

• next