Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963020007> ?p ?o ?g. }
- W2963020007 endingPage "2215" @default.
- W2963020007 startingPage "2205" @default.
- W2963020007 abstract "MicroRNAs play important roles in many biological processes. Their aberrant expression can have oncogenic or tumor suppressor function directly participating to carcinogenesis, malignant transformation, invasiveness and metastasis. Indeed, miRNA profiles can distinguish not only between normal and cancerous tissue but they can also successfully classify different subtypes of a particular cancer. Here, we focus on a particular class of transcripts encoding polycistronic miRNA genes that yields multiple miRNA components. We describe 'clustered MiRNA Master Regulator Analysis (ClustMMRA)', a fully redesigned release of the MMRA computational pipeline (MiRNA Master Regulator Analysis), developed to search for clustered miRNAs potentially driving cancer molecular subtyping. Genomically clustered miRNAs are frequently co-expressed to target different components of pro-tumorigenic signaling pathways. By applying ClustMMRA to breast cancer patient data, we identified key miRNA clusters driving the phenotype of different tumor subgroups. The pipeline was applied to two independent breast cancer datasets, providing statistically concordant results between the two analyses. We validated in cell lines the miR-199/miR-214 as a novel cluster of miRNAs promoting the triple negative breast cancer (TNBC) phenotype through its control of proliferation and EMT." @default.
- W2963020007 created "2019-07-30" @default.
- W2963020007 creator A5009774873 @default.
- W2963020007 creator A5031508753 @default.
- W2963020007 creator A5040229926 @default.
- W2963020007 creator A5042706674 @default.
- W2963020007 creator A5059245033 @default.
- W2963020007 creator A5062067186 @default.
- W2963020007 creator A5063905929 @default.
- W2963020007 creator A5076515219 @default.
- W2963020007 creator A5080043171 @default.
- W2963020007 date "2019-01-18" @default.
- W2963020007 modified "2023-10-13" @default.
- W2963020007 title "Identification of microRNA clusters cooperatively acting on epithelial to mesenchymal transition in triple negative breast cancer" @default.
- W2963020007 cites W144423133 @default.
- W2963020007 cites W1499990855 @default.
- W2963020007 cites W1587132929 @default.
- W2963020007 cites W1969444967 @default.
- W2963020007 cites W1972785590 @default.
- W2963020007 cites W1978944350 @default.
- W2963020007 cites W1979268646 @default.
- W2963020007 cites W1983804343 @default.
- W2963020007 cites W1985563073 @default.
- W2963020007 cites W1987347990 @default.
- W2963020007 cites W1988818350 @default.
- W2963020007 cites W1989827688 @default.
- W2963020007 cites W1994272280 @default.
- W2963020007 cites W2007368465 @default.
- W2963020007 cites W2009326616 @default.
- W2963020007 cites W2010457001 @default.
- W2963020007 cites W2016381498 @default.
- W2963020007 cites W2018173663 @default.
- W2963020007 cites W2023121881 @default.
- W2963020007 cites W2023833090 @default.
- W2963020007 cites W2026570544 @default.
- W2963020007 cites W2033595939 @default.
- W2963020007 cites W2033751993 @default.
- W2963020007 cites W2037275886 @default.
- W2963020007 cites W2039879202 @default.
- W2963020007 cites W2041825143 @default.
- W2963020007 cites W2044702943 @default.
- W2963020007 cites W2047529648 @default.
- W2963020007 cites W2055998706 @default.
- W2963020007 cites W2059806955 @default.
- W2963020007 cites W2062290101 @default.
- W2963020007 cites W2065899119 @default.
- W2963020007 cites W2072510115 @default.
- W2963020007 cites W2077327925 @default.
- W2963020007 cites W2082793779 @default.
- W2963020007 cites W2092166712 @default.
- W2963020007 cites W2094720383 @default.
- W2963020007 cites W2096283457 @default.
- W2963020007 cites W2101136328 @default.
- W2963020007 cites W2107277218 @default.
- W2963020007 cites W2108516575 @default.
- W2963020007 cites W2117692326 @default.
- W2963020007 cites W2124007301 @default.
- W2963020007 cites W2132619562 @default.
- W2963020007 cites W2133763262 @default.
- W2963020007 cites W2137751769 @default.
- W2963020007 cites W2139443896 @default.
- W2963020007 cites W2152059298 @default.
- W2963020007 cites W2153806249 @default.
- W2963020007 cites W2154941270 @default.
- W2963020007 cites W2160938378 @default.
- W2963020007 cites W2164012646 @default.
- W2963020007 cites W2171230529 @default.
- W2963020007 cites W2192080449 @default.
- W2963020007 cites W2263948230 @default.
- W2963020007 cites W2330595999 @default.
- W2963020007 cites W2344940604 @default.
- W2963020007 cites W2560367415 @default.
- W2963020007 cites W2565206471 @default.
- W2963020007 cites W2604228316 @default.
- W2963020007 cites W2616354644 @default.
- W2963020007 cites W2621936089 @default.
- W2963020007 cites W2622917734 @default.
- W2963020007 cites W2757003517 @default.
- W2963020007 cites W2761184186 @default.
- W2963020007 cites W2868772566 @default.
- W2963020007 cites W3099289621 @default.
- W2963020007 cites W3105405781 @default.
- W2963020007 cites W3119878839 @default.
- W2963020007 cites W426664351 @default.
- W2963020007 doi "https://doi.org/10.1093/nar/gkz016" @default.
- W2963020007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6412120" @default.
- W2963020007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30657980" @default.
- W2963020007 hasPublicationYear "2019" @default.
- W2963020007 type Work @default.
- W2963020007 sameAs 2963020007 @default.
- W2963020007 citedByCount "60" @default.
- W2963020007 countsByYear W29630200072019 @default.
- W2963020007 countsByYear W29630200072020 @default.
- W2963020007 countsByYear W29630200072021 @default.
- W2963020007 countsByYear W29630200072022 @default.
- W2963020007 countsByYear W29630200072023 @default.
- W2963020007 crossrefType "journal-article" @default.
- W2963020007 hasAuthorship W2963020007A5009774873 @default.