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• W2963036768 endingPage "59" @default.
• W2963036768 startingPage "44" @default.
• W2963036768 abstract "Glutamate is implicated in the neuropathology of both major depressive disorder and bipolar disorder. Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter in the mammalian brain, removing glutamate from the synaptic cleft and transporting it into glia for recycling. It is thereby the principal regulator of extracellular glutamate levels and prevents neuronal excitotoxicity. EAAT2 is a promising target for elucidating the mechanisms by which the glutamate-glutamine cycle interacts with neuronal systems in mood disorders. Forty EAAT2 studies (published January 1992–January 2018) were identified via a systematic literature search. The studies demonstrated that chronic stress/steroids were most commonly associated with decreased EAAT2. In rodents, EAAT2 inhibition worsened depressive behaviors. Human EAAT2 expression usually decreased in depression, with some regional brain differences. Fewer data have been collected regarding the roles and regulation of EAAT2 in bipolar disorder. Future directions for research include correlating EAAT2 and glutamate levels<i></i>in vivo, elucidating genetic variability and epigenetic regulation, clarifying intracellular protein and pharmacologic interactions, and examining EAAT2 in different bipolar mood states. As part of a macromolecular complex within glia, EAAT2 may contribute significantly to intracellular signaling, energy regulation, and cellular homeostasis. An enhanced understanding of this system is needed." @default.
• W2963036768 created "2019-07-30" @default.
• W2963036768 creator A5013051356 @default.
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• W2963036768 date "2019-01-01" @default.
• W2963036768 modified "2023-10-02" @default.
• W2963036768 title "EAAT2 as a Research Target in Bipolar Disorder and Unipolar Depression: A Systematic Review" @default.
• W2963036768 cites W1511830919 @default.
• W2963036768 cites W1570428653 @default.
• W2963036768 cites W1820117428 @default.
• W2963036768 cites W1828128812 @default.
• W2963036768 cites W1965556606 @default.
• W2963036768 cites W1973750352 @default.
• W2963036768 cites W1980625959 @default.
• W2963036768 cites W1984344128 @default.
• W2963036768 cites W1988912854 @default.
• W2963036768 cites W1991077451 @default.
• W2963036768 cites W1991701465 @default.
• W2963036768 cites W1992337720 @default.
• W2963036768 cites W1994277356 @default.
• W2963036768 cites W2002153537 @default.
• W2963036768 cites W2002675469 @default.
• W2963036768 cites W2003631389 @default.
• W2963036768 cites W2004876835 @default.
• W2963036768 cites W2012108027 @default.
• W2963036768 cites W2012850137 @default.
• W2963036768 cites W2019890311 @default.
• W2963036768 cites W2026274346 @default.
• W2963036768 cites W2029406839 @default.
• W2963036768 cites W2030525076 @default.
• W2963036768 cites W2031598294 @default.
• W2963036768 cites W2040344668 @default.
• W2963036768 cites W2043713804 @default.
• W2963036768 cites W2046274203 @default.
• W2963036768 cites W2048342066 @default.
• W2963036768 cites W2052808411 @default.
• W2963036768 cites W2053668137 @default.
• W2963036768 cites W2058158088 @default.
• W2963036768 cites W2059150405 @default.
• W2963036768 cites W2064803491 @default.
• W2963036768 cites W2064881306 @default.
• W2963036768 cites W2069027482 @default.
• W2963036768 cites W2073345537 @default.
• W2963036768 cites W2075299105 @default.
• W2963036768 cites W2076406171 @default.
• W2963036768 cites W2078542620 @default.
• W2963036768 cites W2082190932 @default.
• W2963036768 cites W2082798838 @default.
• W2963036768 cites W2083004303 @default.
• W2963036768 cites W2083217982 @default.
• W2963036768 cites W2086061811 @default.
• W2963036768 cites W2091166955 @default.
• W2963036768 cites W2094920761 @default.
• W2963036768 cites W2094998611 @default.
• W2963036768 cites W2095267065 @default.
• W2963036768 cites W2112280040 @default.
• W2963036768 cites W2113054165 @default.
• W2963036768 cites W2116563692 @default.
• W2963036768 cites W2119050322 @default.
• W2963036768 cites W2119681380 @default.
• W2963036768 cites W2123936058 @default.
• W2963036768 cites W2136753961 @default.
• W2963036768 cites W2142639021 @default.
• W2963036768 cites W2143594200 @default.
• W2963036768 cites W2150002111 @default.
• W2963036768 cites W2166219187 @default.
• W2963036768 cites W2171669173 @default.
• W2963036768 cites W2180322475 @default.
• W2963036768 cites W2184293 @default.
• W2963036768 cites W2231535902 @default.
• W2963036768 cites W2253752583 @default.
• W2963036768 cites W2256121135 @default.
• W2963036768 cites W2337400527 @default.
• W2963036768 cites W2346726077 @default.
• W2963036768 cites W2406436421 @default.
• W2963036768 cites W2460456403 @default.
• W2963036768 cites W2465845564 @default.
• W2963036768 cites W2511769268 @default.
• W2963036768 cites W2513602948 @default.
• W2963036768 cites W2563366396 @default.
• W2963036768 cites W2589439677 @default.
• W2963036768 cites W2597594542 @default.
• W2963036768 cites W2604691893 @default.
• W2963036768 cites W2738082385 @default.
• W2963036768 cites W2740983034 @default.
• W2963036768 cites W2745116209 @default.
• W2963036768 cites W2767888497 @default.
• W2963036768 cites W2790149673 @default.
• W2963036768 cites W2804623375 @default.
• W2963036768 cites W2811262331 @default.
• W2963036768 cites W2945865979 @default.
• W2963036768 cites W2950375827 @default.
• W2963036768 doi "https://doi.org/10.1159/000501885" @default.

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