FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963055633> ?p ?o ?g. }

• W2963055633 endingPage "110518" @default.
• W2963055633 startingPage "110518" @default.
• W2963055633 abstract "Neuromedin U (NMU) shows circadian expression in the rat pars tuberalis (PT), and is known to be suppressed by melatonin. Here we examined the involvement of adenosine in the regulation of Nmu expression. We found that the rat PT expressed adenosine receptor A2b and that an adenosine receptor agonist, NECA, stimulated Nmu expression in brain slice cultures. In vitro promoter assays revealed that NECA stimulated Nmu promoter activity via a cAMP response element (CRE) in the presence of adenosine receptor A2b. NECA also increased the levels of phosphorylated CRE-binding protein. These findings suggest that adenosine stimulates Nmu expression by activating the cAMP signaling pathway through adenosine receptor A2b in the rat PT. This is the first report to demonstrate that Nmu expression in the PT is regulated by adenosine, which acts as an intravital central metabolic signal, in addition to melatonin, which acts as an external photoperiodic environmental signal. • A2b is the adenosine receptor expressed in the rat pars tuberalis (PT). • Adenosine receptor agonist NECA stimulates Neuromedin U expression in the rat PT. • NECA stimulates Neuromedin U expression by activating the cAMP pathway via A2b. • NECA promotes Neuromedin U promoter activity via the CRE homology element." @default.
• W2963055633 created "2019-07-30" @default.
• W2963055633 creator A5007166081 @default.
• W2963055633 creator A5009345984 @default.
• W2963055633 creator A5027037691 @default.
• W2963055633 creator A5027321893 @default.
• W2963055633 creator A5039051833 @default.
• W2963055633 creator A5044734833 @default.
• W2963055633 creator A5055584432 @default.
• W2963055633 creator A5076782173 @default.
• W2963055633 creator A5080923334 @default.
• W2963055633 creator A5088777526 @default.
• W2963055633 date "2019-10-01" @default.
• W2963055633 modified "2023-10-16" @default.
• W2963055633 title "Adenosine stimulates neuromedin U mRNA expression in the rat pars tuberalis" @default.
• W2963055633 cites W1488526962 @default.
• W2963055633 cites W1551550807 @default.
• W2963055633 cites W1576503935 @default.
• W2963055633 cites W1968812592 @default.
• W2963055633 cites W1969470553 @default.
• W2963055633 cites W1981589604 @default.
• W2963055633 cites W1992958536 @default.
• W2963055633 cites W2001746592 @default.
• W2963055633 cites W2016604807 @default.
• W2963055633 cites W2021679523 @default.
• W2963055633 cites W2024376409 @default.
• W2963055633 cites W2026116105 @default.
• W2963055633 cites W2037573884 @default.
• W2963055633 cites W2038544609 @default.
• W2963055633 cites W2039307767 @default.
• W2963055633 cites W2039673936 @default.
• W2963055633 cites W2042857129 @default.
• W2963055633 cites W2045815714 @default.
• W2963055633 cites W2046337839 @default.
• W2963055633 cites W2046451463 @default.
• W2963055633 cites W2049285778 @default.
• W2963055633 cites W2053269045 @default.
• W2963055633 cites W2060213263 @default.
• W2963055633 cites W2062566674 @default.
• W2963055633 cites W2065428236 @default.
• W2963055633 cites W2067457688 @default.
• W2963055633 cites W2079304693 @default.
• W2963055633 cites W2091066202 @default.
• W2963055633 cites W2091374027 @default.
• W2963055633 cites W2094122594 @default.
• W2963055633 cites W2100043179 @default.
• W2963055633 cites W2110942456 @default.
• W2963055633 cites W2121637377 @default.
• W2963055633 cites W2122178234 @default.
• W2963055633 cites W2122184385 @default.
• W2963055633 cites W2138599948 @default.
• W2963055633 cites W2145758516 @default.
• W2963055633 cites W2146981914 @default.
• W2963055633 doi "https://doi.org/10.1016/j.mce.2019.110518" @default.
• W2963055633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31344393" @default.
• W2963055633 hasPublicationYear "2019" @default.
• W2963055633 type Work @default.
• W2963055633 sameAs 2963055633 @default.
• W2963055633 citedByCount "2" @default.
• W2963055633 countsByYear W29630556332022 @default.
• W2963055633 crossrefType "journal-article" @default.
• W2963055633 hasAuthorship W2963055633A5007166081 @default.
• W2963055633 hasAuthorship W2963055633A5009345984 @default.
• W2963055633 hasAuthorship W2963055633A5027037691 @default.
• W2963055633 hasAuthorship W2963055633A5027321893 @default.
• W2963055633 hasAuthorship W2963055633A5039051833 @default.
• W2963055633 hasAuthorship W2963055633A5044734833 @default.
• W2963055633 hasAuthorship W2963055633A5055584432 @default.
• W2963055633 hasAuthorship W2963055633A5076782173 @default.
• W2963055633 hasAuthorship W2963055633A5080923334 @default.
• W2963055633 hasAuthorship W2963055633A5088777526 @default.
• W2963055633 hasConcept C126322002 @default.
• W2963055633 hasConcept C134018914 @default.
• W2963055633 hasConcept C158424129 @default.
• W2963055633 hasConcept C16587737 @default.
• W2963055633 hasConcept C170493617 @default.
• W2963055633 hasConcept C182683403 @default.
• W2963055633 hasConcept C2776991684 @default.
• W2963055633 hasConcept C2777658017 @default.
• W2963055633 hasConcept C2778938600 @default.
• W2963055633 hasConcept C2779424673 @default.
• W2963055633 hasConcept C62478195 @default.
• W2963055633 hasConcept C67907053 @default.
• W2963055633 hasConcept C71315377 @default.
• W2963055633 hasConcept C71924100 @default.
• W2963055633 hasConcept C86803240 @default.
• W2963055633 hasConcept C95444343 @default.
• W2963055633 hasConceptScore W2963055633C126322002 @default.
• W2963055633 hasConceptScore W2963055633C134018914 @default.
• W2963055633 hasConceptScore W2963055633C158424129 @default.
• W2963055633 hasConceptScore W2963055633C16587737 @default.
• W2963055633 hasConceptScore W2963055633C170493617 @default.
• W2963055633 hasConceptScore W2963055633C182683403 @default.
• W2963055633 hasConceptScore W2963055633C2776991684 @default.
• W2963055633 hasConceptScore W2963055633C2777658017 @default.
• W2963055633 hasConceptScore W2963055633C2778938600 @default.
• W2963055633 hasConceptScore W2963055633C2779424673 @default.
• W2963055633 hasConceptScore W2963055633C62478195 @default.

• next