Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963152376> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2963152376 abstract "To get insight into molecular mechanisms underlying insulin resistance, we compared acute in vivo effects of insulin on adipose tissue transcriptional profiles between obese insulin-resistant and lean insulin-sensitive women. Subcutaneous adipose tissue biopsies were obtained before and after 3 and 6 hours of intravenously maintained euglycemic hyperinsulinemia from 9 insulin-resistant and 11 insulin-sensitive females. Gene expression was measured using Affymetrix HG U133 Plus 2 microarrays and qRT-PCR. Microarray data and pathway analyses were performed with Chipster v1.4.2 and by using in-house developed nonparametric pathway analysis software. The most prominent difference in gene expression of the insulin-resistant group during hyperinsulinemia was reduced transcription of nuclear genes involved in mitochondrial respiration (mitochondrial respiratory chain, GO:0001934). Inflammatory pathways with complement components (inflammatory response, GO:0006954) and cytokines (chemotaxis, GO:0042330) were strongly up-regulated in insulin-resistant as compared to insulin-sensitive subjects both before and during hyperinsulinemia. Furthermore, differences were observed in genes contributing to fatty acid, cholesterol and triglyceride metabolism (FATP2, ELOVL6, PNPLA3, SREBF1) and in genes involved in regulating lipolysis (ANGPTL4) between the insulin-resistant and -sensitive subjects especially during hyperinsulinemia. The major finding of this study was lower expression of mitochondrial respiratory pathway and defective induction of lipid metabolism pathways by insulin in insulin-resistant subjects. Moreover, the study reveals several novel genes whose aberrant regulation is associated with the obese insulin-resistant phenotype." @default.
- W2963152376 created "2019-07-30" @default.
- W2963152376 creator A5002864290 @default.
- W2963152376 creator A5016356740 @default.
- W2963152376 creator A5024138963 @default.
- W2963152376 creator A5028953583 @default.
- W2963152376 creator A5036110343 @default.
- W2963152376 creator A5058300698 @default.
- W2963152376 creator A5075525029 @default.
- W2963152376 creator A5076841174 @default.
- W2963152376 date "2012-01-01" @default.
- W2963152376 modified "2023-10-16" @default.
- W2963152376 title "Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects" @default.
- W2963152376 hasPublicationYear "2012" @default.
- W2963152376 type Work @default.
- W2963152376 sameAs 2963152376 @default.
- W2963152376 citedByCount "0" @default.
- W2963152376 crossrefType "journal-article" @default.
- W2963152376 hasAuthorship W2963152376A5002864290 @default.
- W2963152376 hasAuthorship W2963152376A5016356740 @default.
- W2963152376 hasAuthorship W2963152376A5024138963 @default.
- W2963152376 hasAuthorship W2963152376A5028953583 @default.
- W2963152376 hasAuthorship W2963152376A5036110343 @default.
- W2963152376 hasAuthorship W2963152376A5058300698 @default.
- W2963152376 hasAuthorship W2963152376A5075525029 @default.
- W2963152376 hasAuthorship W2963152376A5076841174 @default.
- W2963152376 hasConcept C126322002 @default.
- W2963152376 hasConcept C134018914 @default.
- W2963152376 hasConcept C171089720 @default.
- W2963152376 hasConcept C2777391703 @default.
- W2963152376 hasConcept C2779306644 @default.
- W2963152376 hasConcept C2780988686 @default.
- W2963152376 hasConcept C71924100 @default.
- W2963152376 hasConcept C86803240 @default.
- W2963152376 hasConceptScore W2963152376C126322002 @default.
- W2963152376 hasConceptScore W2963152376C134018914 @default.
- W2963152376 hasConceptScore W2963152376C171089720 @default.
- W2963152376 hasConceptScore W2963152376C2777391703 @default.
- W2963152376 hasConceptScore W2963152376C2779306644 @default.
- W2963152376 hasConceptScore W2963152376C2780988686 @default.
- W2963152376 hasConceptScore W2963152376C71924100 @default.
- W2963152376 hasConceptScore W2963152376C86803240 @default.
- W2963152376 hasOpenAccess W2963152376 @default.
- W2963152376 hasRelatedWork W1584878576 @default.
- W2963152376 hasRelatedWork W1839001948 @default.
- W2963152376 hasRelatedWork W1968108638 @default.
- W2963152376 hasRelatedWork W1996894913 @default.
- W2963152376 hasRelatedWork W2031466390 @default.
- W2963152376 hasRelatedWork W2043608242 @default.
- W2963152376 hasRelatedWork W2046179164 @default.
- W2963152376 hasRelatedWork W2081871155 @default.
- W2963152376 hasRelatedWork W2111605834 @default.
- W2963152376 hasRelatedWork W2120138523 @default.
- W2963152376 hasRelatedWork W2123923369 @default.
- W2963152376 hasRelatedWork W2160113195 @default.
- W2963152376 hasRelatedWork W2162576384 @default.
- W2963152376 hasRelatedWork W2221984001 @default.
- W2963152376 hasRelatedWork W2370702988 @default.
- W2963152376 hasRelatedWork W3012735698 @default.
- W2963152376 hasRelatedWork W3022548404 @default.
- W2963152376 hasRelatedWork W3160977762 @default.
- W2963152376 hasRelatedWork W3204148594 @default.
- W2963152376 hasRelatedWork W2127216298 @default.
- W2963152376 isParatext "false" @default.
- W2963152376 isRetracted "false" @default.
- W2963152376 magId "2963152376" @default.
- W2963152376 workType "article" @default.