Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963161769> ?p ?o ?g. }
- W2963161769 endingPage "1148" @default.
- W2963161769 startingPage "1133" @default.
- W2963161769 abstract "Despite of the increasing application of silica nanoparticles and identification of oral exposure as a major entry portal, we lack understanding of nanosilica effects in the gut. Thus, we investigated biointeractions of nanosilica with single intestinal cells. The invertebrate nematode Caenorhabditis elegans was chosen as model organism with a tractable intestine and realistic target organism of nanomaterials in the environment. We found that nanosilica impairs the intestinal uptake of oligopeptides. Downstream to absorption by the apical OPT-2/PEP-2 transporter dipeptides were trapped in aberrant vesicles that grow over time and reach diameters of ≥6 μm. The peptide vesicles do not correspond to known organelles such as gut granules and form independently of related gene products GLO-1 or GLO-3. Formation of aberrant peptide vesicles also occurred independently of insulin/IGF-I receptor (DAF-2) signaling and daf-2 loss of function mutants showed specific vesicle patterns including distinct localization along the apical membrane of single intestinal cells. As malnutrition of exposed C. elegans manifested in reduced growth and a petite phenotype similar to OPT-2/PEP-2 transporter deficient mutants, we conclude that nanosilica-induced peptide vesicles represent a new compartment of di- and tripeptide trapping which disrupts hydrolysis of nutrient peptides and metabolism." @default.
- W2963161769 created "2019-07-30" @default.
- W2963161769 creator A5040917050 @default.
- W2963161769 creator A5085310036 @default.
- W2963161769 creator A5091421447 @default.
- W2963161769 date "2019-08-09" @default.
- W2963161769 modified "2023-09-26" @default.
- W2963161769 title "Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium" @default.
- W2963161769 cites W1515211957 @default.
- W2963161769 cites W1548405860 @default.
- W2963161769 cites W1594755745 @default.
- W2963161769 cites W1906684901 @default.
- W2963161769 cites W1944127002 @default.
- W2963161769 cites W1969035712 @default.
- W2963161769 cites W1971510877 @default.
- W2963161769 cites W1975539651 @default.
- W2963161769 cites W1982221599 @default.
- W2963161769 cites W1982471617 @default.
- W2963161769 cites W1998470289 @default.
- W2963161769 cites W2003572328 @default.
- W2963161769 cites W2005959098 @default.
- W2963161769 cites W2008785965 @default.
- W2963161769 cites W2011859278 @default.
- W2963161769 cites W2012387790 @default.
- W2963161769 cites W2013129165 @default.
- W2963161769 cites W2015173256 @default.
- W2963161769 cites W2016107719 @default.
- W2963161769 cites W2022946283 @default.
- W2963161769 cites W2023018514 @default.
- W2963161769 cites W2026543948 @default.
- W2963161769 cites W2034913511 @default.
- W2963161769 cites W2038840837 @default.
- W2963161769 cites W2054892907 @default.
- W2963161769 cites W2058484936 @default.
- W2963161769 cites W2066539222 @default.
- W2963161769 cites W2075379877 @default.
- W2963161769 cites W2075739226 @default.
- W2963161769 cites W2089124524 @default.
- W2963161769 cites W2093999591 @default.
- W2963161769 cites W2097413900 @default.
- W2963161769 cites W2099971177 @default.
- W2963161769 cites W2122169298 @default.
- W2963161769 cites W2124405852 @default.
- W2963161769 cites W2129832331 @default.
- W2963161769 cites W2138731844 @default.
- W2963161769 cites W2141200742 @default.
- W2963161769 cites W2143242448 @default.
- W2963161769 cites W2144260007 @default.
- W2963161769 cites W2146688490 @default.
- W2963161769 cites W2150567145 @default.
- W2963161769 cites W2151893314 @default.
- W2963161769 cites W2155118487 @default.
- W2963161769 cites W2166732191 @default.
- W2963161769 cites W2169687949 @default.
- W2963161769 cites W2172047282 @default.
- W2963161769 cites W2209516442 @default.
- W2963161769 cites W2323824056 @default.
- W2963161769 cites W2517438771 @default.
- W2963161769 cites W2551411375 @default.
- W2963161769 cites W2617208483 @default.
- W2963161769 cites W2761328555 @default.
- W2963161769 cites W2762477858 @default.
- W2963161769 cites W2764251932 @default.
- W2963161769 cites W2766268933 @default.
- W2963161769 cites W2783300564 @default.
- W2963161769 cites W2787628252 @default.
- W2963161769 cites W2799503867 @default.
- W2963161769 cites W871129216 @default.
- W2963161769 doi "https://doi.org/10.1080/17435390.2019.1643048" @default.
- W2963161769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31340706" @default.
- W2963161769 hasPublicationYear "2019" @default.
- W2963161769 type Work @default.
- W2963161769 sameAs 2963161769 @default.
- W2963161769 citedByCount "15" @default.
- W2963161769 countsByYear W29631617692020 @default.
- W2963161769 countsByYear W29631617692021 @default.
- W2963161769 countsByYear W29631617692022 @default.
- W2963161769 countsByYear W29631617692023 @default.
- W2963161769 crossrefType "journal-article" @default.
- W2963161769 hasAuthorship W2963161769A5040917050 @default.
- W2963161769 hasAuthorship W2963161769A5085310036 @default.
- W2963161769 hasAuthorship W2963161769A5091421447 @default.
- W2963161769 hasBestOaLocation W29631617691 @default.
- W2963161769 hasConcept C104317684 @default.
- W2963161769 hasConcept C12554922 @default.
- W2963161769 hasConcept C130316041 @default.
- W2963161769 hasConcept C13935069 @default.
- W2963161769 hasConcept C143065580 @default.
- W2963161769 hasConcept C149011108 @default.
- W2963161769 hasConcept C185592680 @default.
- W2963161769 hasConcept C2776878037 @default.
- W2963161769 hasConcept C2778944004 @default.
- W2963161769 hasConcept C2779281246 @default.
- W2963161769 hasConcept C2781077229 @default.
- W2963161769 hasConcept C41625074 @default.
- W2963161769 hasConcept C529295009 @default.
- W2963161769 hasConcept C54355233 @default.
- W2963161769 hasConcept C55493867 @default.