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- W2963192783 abstract "To systematically review the available literature for the management of oligometastatic squamous cell carcinoma of the head and neck (SCCHN). Articles were selected from English Medline literature between 1995 and 2018, searched by using the key words: oligometastatic Head and Neck cancer/metastasectomy/SBRT. Treatment of the primary disease: National Cancer Data Base (NCDB) analysis reported 13% improvement in 2-year overall survival (OS) for patients with metastatic SCCHN receiving high intensity local treatment and systemic therapy. Multiple retrospective series from China and SEER data base analysis from the US has confirmed similar findings in oligometastatic nasopharyngeal cancer, but data on other sites of head and neck cancers are limited. In a retrospective series from Germany, the authors noted a significant improvement in the median survival from 7 months to 24 months for patients who received local therapy for metastatic disease with curative intent by metastasectomy or Stereotactic Body Radiation Therapy (SBRT). A metanalysis of pulmonary metastasectomies in oligometastatic SCCHN patients demonstrated a 5- year OS of 29%. A single institutional retrospective review of 77 patients (75% with SCCHN) who underwent metastasectomy reported a median survival of 66 months and 5-year OS of 54%. In another retrospective review of 105 oligometastatic patients (16% with SCCHN primary) treated with SBRT, authors reported median overall survival of 45.3 months and 3-year OS of 60%. A recently reported Phase II trial of SBRT for oligometastatic cancer (10% with SCCHN) reported a median survival of 17.6 months and a 5- year OS of 42% in the head and neck cohort. An analysis by Widder et al. compared metastasectomy with SBRT in this setting and reported no significant differences in OS or local control. Oligometastatic SCCHN patients have better prognosis if treated aggressively. Further investigation is warranted." @default.
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- W2963192783 date "2019-08-01" @default.
- W2963192783 modified "2023-10-10" @default.
- W2963192783 title "Management of Oligometastatic Squamous Cell Carcinoma of the Head and Neck" @default.
- W2963192783 doi "https://doi.org/10.1016/j.ijrobp.2019.05.048" @default.
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