Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963197267> ?p ?o ?g. }
- W2963197267 endingPage "119373" @default.
- W2963197267 startingPage "119373" @default.
- W2963197267 abstract "Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies. Here we used peptide phage biopanning to identify a novel targeting peptide (PL1, sequence: PPRRGLIKLKTS) that interacts with both FN-EDB and TNC-C. Systemic PL1-functionalized model nanoscale payloads [iron oxide nanoworms (NWs) and metallic silver nanoparticles] homed to glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced by VEGF-overexpression. Antibody blockage experiments demonstrated that PL1 tumor homing involved interactions with both receptor proteins. Treatment of GBM mice with PL1-targeted model therapeutic nanocarrier (NWs loaded with a proapoptotic peptide) resulted in reduced tumor growth and increased survival, whereas treatment with untargeted particles had no effect. PL1 peptide may have applications as an affinity ligand for delivery of diagnostic and therapeutic compounds to microenvironment of solid tumors." @default.
- W2963197267 created "2019-07-30" @default.
- W2963197267 creator A5001257443 @default.
- W2963197267 creator A5020277720 @default.
- W2963197267 creator A5022770670 @default.
- W2963197267 creator A5029622971 @default.
- W2963197267 creator A5033837180 @default.
- W2963197267 creator A5048130381 @default.
- W2963197267 creator A5050818179 @default.
- W2963197267 creator A5057677884 @default.
- W2963197267 creator A5065173224 @default.
- W2963197267 creator A5088164052 @default.
- W2963197267 date "2019-10-01" @default.
- W2963197267 modified "2023-10-14" @default.
- W2963197267 title "Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery" @default.
- W2963197267 cites W111402081 @default.
- W2963197267 cites W1491619495 @default.
- W2963197267 cites W1550662048 @default.
- W2963197267 cites W1587050401 @default.
- W2963197267 cites W1989658253 @default.
- W2963197267 cites W1997894998 @default.
- W2963197267 cites W1998482661 @default.
- W2963197267 cites W2013828963 @default.
- W2963197267 cites W2025628768 @default.
- W2963197267 cites W2029569254 @default.
- W2963197267 cites W2042222860 @default.
- W2963197267 cites W2043944189 @default.
- W2963197267 cites W2045250262 @default.
- W2963197267 cites W2053662322 @default.
- W2963197267 cites W2059126737 @default.
- W2963197267 cites W2073629335 @default.
- W2963197267 cites W2087240594 @default.
- W2963197267 cites W2087484885 @default.
- W2963197267 cites W2089403444 @default.
- W2963197267 cites W2111601282 @default.
- W2963197267 cites W2130389715 @default.
- W2963197267 cites W2135713425 @default.
- W2963197267 cites W2148276738 @default.
- W2963197267 cites W2151442561 @default.
- W2963197267 cites W2156587383 @default.
- W2963197267 cites W2157451292 @default.
- W2963197267 cites W2158287992 @default.
- W2963197267 cites W2163326536 @default.
- W2963197267 cites W2168587151 @default.
- W2963197267 cites W2177463952 @default.
- W2963197267 cites W2187117619 @default.
- W2963197267 cites W2284089480 @default.
- W2963197267 cites W2313899111 @default.
- W2963197267 cites W2575998194 @default.
- W2963197267 cites W2600609026 @default.
- W2963197267 cites W2730694093 @default.
- W2963197267 cites W2750969044 @default.
- W2963197267 cites W2774294088 @default.
- W2963197267 cites W2794097834 @default.
- W2963197267 cites W2807235246 @default.
- W2963197267 cites W2890063360 @default.
- W2963197267 doi "https://doi.org/10.1016/j.biomaterials.2019.119373" @default.
- W2963197267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31374479" @default.
- W2963197267 hasPublicationYear "2019" @default.
- W2963197267 type Work @default.
- W2963197267 sameAs 2963197267 @default.
- W2963197267 citedByCount "38" @default.
- W2963197267 countsByYear W29631972672020 @default.
- W2963197267 countsByYear W29631972672021 @default.
- W2963197267 countsByYear W29631972672022 @default.
- W2963197267 countsByYear W29631972672023 @default.
- W2963197267 crossrefType "journal-article" @default.
- W2963197267 hasAuthorship W2963197267A5001257443 @default.
- W2963197267 hasAuthorship W2963197267A5020277720 @default.
- W2963197267 hasAuthorship W2963197267A5022770670 @default.
- W2963197267 hasAuthorship W2963197267A5029622971 @default.
- W2963197267 hasAuthorship W2963197267A5033837180 @default.
- W2963197267 hasAuthorship W2963197267A5048130381 @default.
- W2963197267 hasAuthorship W2963197267A5050818179 @default.
- W2963197267 hasAuthorship W2963197267A5057677884 @default.
- W2963197267 hasAuthorship W2963197267A5065173224 @default.
- W2963197267 hasAuthorship W2963197267A5088164052 @default.
- W2963197267 hasBestOaLocation W29631972671 @default.
- W2963197267 hasConcept C104317684 @default.
- W2963197267 hasConcept C104428545 @default.
- W2963197267 hasConcept C117961784 @default.
- W2963197267 hasConcept C153911025 @default.
- W2963197267 hasConcept C164144092 @default.
- W2963197267 hasConcept C167625842 @default.
- W2963197267 hasConcept C171250308 @default.
- W2963197267 hasConcept C18150654 @default.
- W2963197267 hasConcept C185592680 @default.
- W2963197267 hasConcept C189165786 @default.
- W2963197267 hasConcept C192562407 @default.
- W2963197267 hasConcept C2776471321 @default.
- W2963197267 hasConcept C2777738151 @default.
- W2963197267 hasConcept C2779281246 @default.
- W2963197267 hasConcept C2779820397 @default.
- W2963197267 hasConcept C502942594 @default.
- W2963197267 hasConcept C55493867 @default.
- W2963197267 hasConcept C86492073 @default.
- W2963197267 hasConcept C86803240 @default.
- W2963197267 hasConcept C95444343 @default.