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• W2963210725 abstract "// Fengdan Ye 1, 2, * , Dongya Jia 2, 3, * , Mingyang Lu 4 , Herbert Levine 1, 2, 5, 6 and Michael W. Deem 1, 2, 3, 5 1 Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA 2 Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA 3 Program in Systems, Synthetic and Physical Biology, Rice University, Houston, TX 77005, USA 4 The Jackson Laboratory, Bar Harbor, ME 04609, USA 5 Department of Bioengineering, Rice University, Houston, TX 77005, USA 6 Department of Biosciences, Rice University, Houston, TX 77005, USA * Co-first authorship Correspondence to: Michael W. Deem, email: mwdeem@rice.edu Herbert Levine, email: herbert.levine@rice.edu Keywords: modularity; metabolism; hepatocellular carcinoma; HCC; prognosis Received: September 22, 2017      Accepted: February 10, 2018      Epub: February 22, 2018      Published: March 13, 2018 ABSTRACT Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthesis. Understanding the metabolic reprogramming in cancer can help design therapies to target metabolism and thereby to improve prognosis. We have previously argued that more malignant tumors are usually characterized by a more modular expression pattern of cancer-associated genes. In this work, we analyzed the expression patterns of metabolism genes in terms of modularity for 371 hepatocellular carcinoma (HCC) samples from the Cancer Genome Atlas (TCGA). We found that higher modularity significantly correlated with glycolytic phenotype, later tumor stages, higher metastatic potential, and cancer recurrence, all of which contributed to poorer prognosis. Among patients with recurred tumors, we found the correlation of higher modularity with worse prognosis during early to mid-progression. Furthermore, we developed metrics to calculate individual modularity, which was shown to be predictive of cancer recurrence and patients’ survival and therefore may serve as a prognostic biomarker. Our overall conclusion is that more aggressive HCC tumors, as judged by decreased host survival probability, had more modular expression patterns of metabolic genes. These results may be used to identify cancer driver genes and for drug design." @default.
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• W2963210725 date "2018-02-22" @default.
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• W2963210725 title "Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma" @default.
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• W2963210725 doi "https://doi.org/10.18632/oncotarget.24551" @default.
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