FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963217810> ?p ?o ?g. }

• W2963217810 endingPage "118553" @default.
• W2963217810 startingPage "118553" @default.
• W2963217810 abstract "Blending two polymers is an effective technique to obtain a novel material with desirable properties. Chitosan (CH) has limited applications in tissue engineering owing to its poor mechanical strength in a wet state. Polycaprolactone (PCL) has low toxicity with good mechanical strength and controlled release properties, but lack cell recognition signals. Thus, the blending of CH and PCL (CH/PCL) polymers would provide a better biomaterial required for the management of chronic osteomyelitis (OM) after surgical debridement possessing superior physicomechanical and controlled release properties. Herein, blend sponges using different ratios of CH and PCL, i.e., 100%CH/00%PCL, 75%CH/25%PCL, 50%CH/50%PCL and 25%CH/75%PCL were prepared, which are denoted as 100CH/00PCL, 75CH/25PCL, 50CH/50PCL and 25CH/75PCL, respectively. These blend sponges were characterized using FTIR, XRD, DSC, SEM, and contact angle. The results revealed that CH and PCL polymers were well dispersed in a blend at a molecular level without any chemical interactions. Blend sponges were loaded with ciprofloxacin hydrochloride (CIP) and ibuprofen. Further, in vitro efficacy of drug-loaded blend sponges was evaluated for drug release, antibacterial potential, and anti-inflammatory activity. Amongst four blend sponges, the 75CH/25PCL sponge demonstrated the controlled release of ibuprofen and an ideal release profile of CIP along with potential antibacterial as well as anti-inflammatory activity over the study period. Thus, it can be concluded that the 75CH/25PCL sponge is a promising candidate for the management of chronic OM after surgical debridement." @default.
• W2963217810 created "2019-07-30" @default.
• W2963217810 creator A5033851497 @default.
• W2963217810 creator A5037362936 @default.
• W2963217810 date "2019-09-01" @default.
• W2963217810 modified "2023-10-01" @default.
• W2963217810 title "Chitosan-polycaprolactone blend sponges for management of chronic osteomyelitis: A preliminary characterization and in vitro evaluation" @default.
• W2963217810 cites W1965395689 @default.
• W2963217810 cites W1971561276 @default.
• W2963217810 cites W1990756483 @default.
• W2963217810 cites W1991938772 @default.
• W2963217810 cites W2003563357 @default.
• W2963217810 cites W2006850223 @default.
• W2963217810 cites W2007900773 @default.
• W2963217810 cites W2008151430 @default.
• W2963217810 cites W2008827477 @default.
• W2963217810 cites W2013127210 @default.
• W2963217810 cites W2015226517 @default.
• W2963217810 cites W2015680138 @default.
• W2963217810 cites W2016117092 @default.
• W2963217810 cites W2017373675 @default.
• W2963217810 cites W2019988730 @default.
• W2963217810 cites W2027040701 @default.
• W2963217810 cites W2028470122 @default.
• W2963217810 cites W2036986553 @default.
• W2963217810 cites W2038492285 @default.
• W2963217810 cites W2042864468 @default.
• W2963217810 cites W2042895192 @default.
• W2963217810 cites W2056241575 @default.
• W2963217810 cites W2057312516 @default.
• W2963217810 cites W2061940073 @default.
• W2963217810 cites W2069057064 @default.
• W2963217810 cites W2069090993 @default.
• W2963217810 cites W2069851901 @default.
• W2963217810 cites W2073293681 @default.
• W2963217810 cites W2073490411 @default.
• W2963217810 cites W2077855411 @default.
• W2963217810 cites W2085611905 @default.
• W2963217810 cites W2086588103 @default.
• W2963217810 cites W2095378035 @default.
• W2963217810 cites W2098172959 @default.
• W2963217810 cites W2108473418 @default.
• W2963217810 cites W2108769607 @default.
• W2963217810 cites W2111574571 @default.
• W2963217810 cites W2118263648 @default.
• W2963217810 cites W2130892410 @default.
• W2963217810 cites W2139043838 @default.
• W2963217810 cites W2158901274 @default.
• W2963217810 cites W2167815065 @default.
• W2963217810 cites W2233349022 @default.
• W2963217810 cites W2318261123 @default.
• W2963217810 cites W2342741900 @default.
• W2963217810 cites W2463095863 @default.
• W2963217810 cites W2496851488 @default.
• W2963217810 cites W2577124632 @default.
• W2963217810 cites W2608398996 @default.
• W2963217810 cites W2624625590 @default.
• W2963217810 cites W2765574741 @default.
• W2963217810 cites W2776496710 @default.
• W2963217810 cites W2799865292 @default.
• W2963217810 cites W2896944234 @default.
• W2963217810 cites W2906063321 @default.
• W2963217810 cites W2913554941 @default.
• W2963217810 cites W2917219806 @default.
• W2963217810 cites W2942415783 @default.
• W2963217810 cites W2943279636 @default.
• W2963217810 cites W4205294896 @default.
• W2963217810 doi "https://doi.org/10.1016/j.ijpharm.2019.118553" @default.
• W2963217810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31344444" @default.
• W2963217810 hasPublicationYear "2019" @default.
• W2963217810 type Work @default.
• W2963217810 sameAs 2963217810 @default.
• W2963217810 citedByCount "22" @default.
• W2963217810 countsByYear W29632178102020 @default.
• W2963217810 countsByYear W29632178102021 @default.
• W2963217810 countsByYear W29632178102022 @default.
• W2963217810 countsByYear W29632178102023 @default.
• W2963217810 crossrefType "journal-article" @default.
• W2963217810 hasAuthorship W2963217810A5033851497 @default.
• W2963217810 hasAuthorship W2963217810A5037362936 @default.
• W2963217810 hasConcept C15920480 @default.
• W2963217810 hasConcept C159985019 @default.
• W2963217810 hasConcept C171250308 @default.
• W2963217810 hasConcept C178790620 @default.
• W2963217810 hasConcept C185592680 @default.
• W2963217810 hasConcept C187404810 @default.
• W2963217810 hasConcept C192562407 @default.
• W2963217810 hasConcept C2778414984 @default.
• W2963217810 hasConcept C2778512257 @default.
• W2963217810 hasConcept C2778849931 @default.
• W2963217810 hasConcept C2779732960 @default.
• W2963217810 hasConcept C2779868350 @default.
• W2963217810 hasConcept C2779944601 @default.
• W2963217810 hasConcept C2909582096 @default.
• W2963217810 hasConcept C501593827 @default.
• W2963217810 hasConcept C521977710 @default.
• W2963217810 hasConcept C55493867 @default.
• W2963217810 hasConcept C59822182 @default.

• next