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• W2963266117 abstract "Abstract Iron delivery to the developing brain is essential for energy and metabolic support needed for processes such as myelination and neuronal development. Iron deficiency, especially in the developing brain, can result in a number of long‐term neurological deficits that persist into adulthood. There is considerable debate that excess access to iron during development may result in iron overload in the brain and subsequently predispose individuals to age‐related neurodegenerative diseases. There is a significant gap in knowledge regarding how the brain acquires iron during development and how biological variables such as development, genetics, and sex impact brain iron status. In this study, we used a mouse model expressing a mutant form of the iron homeostatic regulator protein HFE, ( Hfe H63D), the most common gene variant in Caucasians, to determine impact of the mutation on brain iron uptake. Iron uptake was assessed using 59 Fe bound to either transferrin or H‐ferritin as the iron carrier proteins. We demonstrate that at postnatal day 22, mutant mice brains take up greater amounts of iron compared with wildtype. Moreover, we introduce H‐ferritin as a key protein in brain iron transport during development and identify a sex and genotype effect demonstrating female mutant mice take up more iron by transferrin, whereas male mutant mice take up more iron from H‐ferritin at PND22. Furthermore, we begin to elucidate the mechanism for uptake using immunohistochemistry to profile the regional distribution and temporal expression of transferrin receptor and T‐cell immunoglobulin and mucin domain 2, the latter is the receptor for H‐ferritin. These data demonstrate that sex and genotype have significant effects on iron uptake and that regional receptor expression may play a large role in the uptake patterns during development. image Open Science: This manuscript was awarded with the Open Materials Badge For more information see: https://cos.io/our-services/open-science-badges/ Cover Image for this issue: doi: 10.1111/jnc.14731 ." @default.
• W2963266117 created "2019-07-30" @default.
• W2963266117 creator A5011344958 @default.
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• W2963266117 date "2019-08-22" @default.
• W2963266117 modified "2023-10-10" @default.
• W2963266117 title "Transferrin and H‐ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype" @default.
• W2963266117 cites W1814180389 @default.
• W2963266117 cites W1945987068 @default.
• W2963266117 cites W1962658604 @default.
• W2963266117 cites W1965571310 @default.
• W2963266117 cites W1970672739 @default.
• W2963266117 cites W1977308172 @default.
• W2963266117 cites W1980298189 @default.
• W2963266117 cites W1981328487 @default.
• W2963266117 cites W1981352341 @default.
• W2963266117 cites W1987695717 @default.
• W2963266117 cites W1991701428 @default.
• W2963266117 cites W1996201704 @default.
• W2963266117 cites W1997753515 @default.
• W2963266117 cites W1997977268 @default.
• W2963266117 cites W2003069734 @default.
• W2963266117 cites W2007610160 @default.
• W2963266117 cites W2010454129 @default.
• W2963266117 cites W2016817836 @default.
• W2963266117 cites W2017091184 @default.
• W2963266117 cites W2022523341 @default.
• W2963266117 cites W2025009096 @default.
• W2963266117 cites W2028241732 @default.
• W2963266117 cites W2039375795 @default.
• W2963266117 cites W2039583114 @default.
• W2963266117 cites W2040160279 @default.
• W2963266117 cites W2045465366 @default.
• W2963266117 cites W2051061512 @default.
• W2963266117 cites W2055009588 @default.
• W2963266117 cites W2056993431 @default.
• W2963266117 cites W2060669542 @default.
• W2963266117 cites W2063804160 @default.
• W2963266117 cites W2065425185 @default.
• W2963266117 cites W2070883646 @default.
• W2963266117 cites W2072159717 @default.
• W2963266117 cites W2074058780 @default.
• W2963266117 cites W2074583930 @default.
• W2963266117 cites W2077087696 @default.
• W2963266117 cites W2078085048 @default.
• W2963266117 cites W2083507370 @default.
• W2963266117 cites W2101534522 @default.
• W2963266117 cites W2103979587 @default.
• W2963266117 cites W2108517583 @default.
• W2963266117 cites W2109197086 @default.
• W2963266117 cites W2110569992 @default.
• W2963266117 cites W2115541385 @default.
• W2963266117 cites W2117339718 @default.
• W2963266117 cites W2125235322 @default.
• W2963266117 cites W2125583607 @default.
• W2963266117 cites W2128628371 @default.
• W2963266117 cites W2136250522 @default.
• W2963266117 cites W2141150980 @default.
• W2963266117 cites W2142644783 @default.
• W2963266117 cites W2144955797 @default.
• W2963266117 cites W2148012914 @default.
• W2963266117 cites W2148362837 @default.
• W2963266117 cites W2157669002 @default.
• W2963266117 cites W2158562886 @default.
• W2963266117 cites W2215765427 @default.
• W2963266117 cites W2307324788 @default.
• W2963266117 cites W2480216102 @default.
• W2963266117 cites W2592506038 @default.
• W2963266117 cites W2602820148 @default.
• W2963266117 cites W2603130010 @default.
• W2963266117 cites W2613045394 @default.
• W2963266117 cites W2624670870 @default.
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• W2963266117 cites W2808060318 @default.
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• W2963266117 doi "https://doi.org/10.1111/jnc.14834" @default.
• W2963266117 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6980902" @default.
• W2963266117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31339576" @default.
• W2963266117 hasPublicationYear "2019" @default.
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