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- W2963291311 abstract "Phlomis fruticosa L. and P. herba‐venti are species belonging to the Lamiaceae family, which have been traditionally used to prepare tonic and digestive drinks. Multiple studies also demonstrated the inhibitory effects of P. fruticosa extracts and essential oil against oxidative/proinflammatory pathways and bacterial strains deeply involved in ulcerative colitis. Considering these findings, the present study evaluated the effects of alcoholic P. fruticosa and P. herba‐venti leaf extracts in isolated rat colon challenged with Escherichia coli lipopolysaccharide (LPS), an ex vivo experimental paradigm of ulcerative colitis. In this context, we assayed colon levels of pro‐oxidant and proinflammatory biomarkers, including nitrites, malondialdehyde (MDA), lactate dehydrogenase (LDH), and serotonin (5‐HT). Additionally, the extracts have been tested in order to evaluate possible inhibitory effects on specific bacterial and fungal strains involved in ulcerative colitis. Alcoholic P. fruticosa and P. herba‐venti extracts were able to blunt LPS‐induced nitrite, MDA, 5‐HT, and LDH levels in isolated rat colon. The same extracts also inhibited the growth of Pseudomonas aeruginosa , E. coli , Staphylococcus aureus , Candida albicans and Candida tropicalis . In conclusion, our findings show a potential role exerted by alcoholic P. fruticosa and P. herba‐venti in managing the clinical symptoms related to ulcerative colitis." @default.
- W2963291311 created "2019-07-30" @default.
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- W2963291311 date "2019-07-19" @default.
- W2963291311 modified "2023-10-02" @default.
- W2963291311 title "Protective effects induced by alcoholic <scp> <i>Phlomis fruticosa</i> </scp> and <scp> <i>Phlomis herba‐venti</i> </scp> extracts in isolated rat colon: Focus on antioxidant, anti‐inflammatory, and antimicrobial activities in vitro" @default.
- W2963291311 cites W1496133404 @default.
- W2963291311 cites W1536251920 @default.
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- W2963291311 cites W1963796196 @default.
- W2963291311 cites W1967949491 @default.
- W2963291311 cites W1972474555 @default.
- W2963291311 cites W1975407855 @default.
- W2963291311 cites W1976327936 @default.
- W2963291311 cites W1978841275 @default.
- W2963291311 cites W1979850209 @default.
- W2963291311 cites W1983731023 @default.
- W2963291311 cites W1984991776 @default.
- W2963291311 cites W1985031521 @default.
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- W2963291311 cites W1991081070 @default.
- W2963291311 cites W1994858192 @default.
- W2963291311 cites W1999812913 @default.
- W2963291311 cites W2003718301 @default.
- W2963291311 cites W2004445259 @default.
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- W2963291311 cites W2019819611 @default.
- W2963291311 cites W2022436928 @default.
- W2963291311 cites W2026131105 @default.
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- W2963291311 cites W2036743290 @default.
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- W2963291311 cites W2065285168 @default.
- W2963291311 cites W2071474576 @default.
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- W2963291311 cites W2111860526 @default.
- W2963291311 cites W2120466256 @default.
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- W2963291311 cites W2584280942 @default.
- W2963291311 cites W2593880180 @default.
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- W2963291311 doi "https://doi.org/10.1002/ptr.6429" @default.
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