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- W2963294103 abstract "Radical radiotherapy for prostate cancer offers excellent long-term outcomes for patients with high-risk disease. The increased risk of pelvic nodal involvement in this cohort has led to the development of whole-pelvis radiotherapy (WPRT) with a prostate boost. However, the use of WPRT remains controversial. Data are mixed, but advanced radiotherapy techniques enable delivery of increased radiation to pelvic nodes with acceptable levels of toxicity. Contemporary imaging modalities with increased sensitivity for detecting subclinical lymph node disease will facilitate selection of patients most likely to benefit from WPRT. Using such modalities for image guidance of advanced radiotherapy techniques could also permit high-dose delivery to nodes outside the conventional Radiation Therapy Oncology Group volumes, where magnetic resonance lymphography and single-photon-emission CT imaging have mapped a high frequency of microscopic disease. With increased toxicity a concern, an alternative to WPRT would be selective irradiation of target nodal groups most likely to harbour occult disease. New image-based 'big data' mining techniques enable the large-scale comparison of incidental dose distributions of thousands of patients treated in the past. By using novel computing methods and artificial intelligence, high-risk regions can be identified and used to optimize WPRT through refined knowledge of the likely location of subclinical disease." @default.
- W2963294103 created "2019-07-30" @default.
- W2963294103 creator A5009101796 @default.
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- W2963294103 creator A5041859071 @default.
- W2963294103 creator A5064462739 @default.
- W2963294103 date "2019-07-25" @default.
- W2963294103 modified "2023-10-06" @default.
- W2963294103 title "New approaches for effective and safe pelvic radiotherapy in high-risk prostate cancer" @default.
- W2963294103 cites W1237963917 @default.
- W2963294103 cites W1490266165 @default.
- W2963294103 cites W1521292045 @default.
- W2963294103 cites W1523533702 @default.
- W2963294103 cites W190857994 @default.
- W2963294103 cites W1965408806 @default.
- W2963294103 cites W1969543525 @default.
- W2963294103 cites W1971596590 @default.
- W2963294103 cites W1975271321 @default.
- W2963294103 cites W1975601063 @default.
- W2963294103 cites W1975618246 @default.
- W2963294103 cites W1976457319 @default.
- W2963294103 cites W1977265573 @default.
- W2963294103 cites W1978735755 @default.
- W2963294103 cites W1979234968 @default.
- W2963294103 cites W1980942911 @default.
- W2963294103 cites W1984369681 @default.
- W2963294103 cites W1986792629 @default.
- W2963294103 cites W1993308240 @default.
- W2963294103 cites W1996123936 @default.
- W2963294103 cites W1998214642 @default.
- W2963294103 cites W2001273577 @default.
- W2963294103 cites W2001616768 @default.
- W2963294103 cites W2004423705 @default.
- W2963294103 cites W2004601306 @default.
- W2963294103 cites W2005887998 @default.
- W2963294103 cites W2007940501 @default.
- W2963294103 cites W2008090769 @default.
- W2963294103 cites W2010016760 @default.
- W2963294103 cites W2010126914 @default.
- W2963294103 cites W2010927620 @default.
- W2963294103 cites W2011197894 @default.
- W2963294103 cites W2013073654 @default.
- W2963294103 cites W2013749950 @default.
- W2963294103 cites W2014420251 @default.
- W2963294103 cites W2015322079 @default.
- W2963294103 cites W2016973566 @default.
- W2963294103 cites W2018482886 @default.
- W2963294103 cites W2021220421 @default.
- W2963294103 cites W2025716600 @default.
- W2963294103 cites W2025813238 @default.
- W2963294103 cites W2027236201 @default.
- W2963294103 cites W2031377216 @default.
- W2963294103 cites W2032856096 @default.
- W2963294103 cites W2035935275 @default.
- W2963294103 cites W2037762374 @default.
- W2963294103 cites W2037968286 @default.
- W2963294103 cites W2039978974 @default.
- W2963294103 cites W2040818579 @default.
- W2963294103 cites W2041276196 @default.
- W2963294103 cites W2047728542 @default.
- W2963294103 cites W2047774497 @default.
- W2963294103 cites W2051133253 @default.
- W2963294103 cites W2054899405 @default.
- W2963294103 cites W2055233890 @default.
- W2963294103 cites W2059106314 @default.
- W2963294103 cites W2062313368 @default.
- W2963294103 cites W2063266750 @default.
- W2963294103 cites W2063931072 @default.
- W2963294103 cites W2069529150 @default.
- W2963294103 cites W2069843205 @default.
- W2963294103 cites W2073021546 @default.
- W2963294103 cites W2073207929 @default.
- W2963294103 cites W2073229943 @default.
- W2963294103 cites W2074579587 @default.
- W2963294103 cites W2074621482 @default.
- W2963294103 cites W2075954920 @default.
- W2963294103 cites W2078319086 @default.
- W2963294103 cites W2090860169 @default.
- W2963294103 cites W2091083791 @default.
- W2963294103 cites W2095986103 @default.
- W2963294103 cites W2097532477 @default.
- W2963294103 cites W2104445823 @default.
- W2963294103 cites W2110429519 @default.
- W2963294103 cites W2112887165 @default.
- W2963294103 cites W2114408678 @default.
- W2963294103 cites W2116692433 @default.
- W2963294103 cites W2116810900 @default.
- W2963294103 cites W2117511763 @default.
- W2963294103 cites W2117792530 @default.
- W2963294103 cites W2118792538 @default.
- W2963294103 cites W2123161437 @default.
- W2963294103 cites W2124107794 @default.
- W2963294103 cites W2124586180 @default.
- W2963294103 cites W2125835130 @default.
- W2963294103 cites W2128365260 @default.
- W2963294103 cites W2130288085 @default.
- W2963294103 cites W2140404153 @default.