Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963333482> ?p ?o ?g. }
- W2963333482 endingPage "154784" @default.
- W2963333482 startingPage "154784" @default.
- W2963333482 abstract "Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is the most spread clinical form of leishmaniasis in Brazil. However, only a few part of the people infected develop clinically perceptive disease, suggesting the influence of human genetic components in the CL pathogeny. The rs2275913 SNP is the nucleotide variant of the IL17A gene. The A allele is associated with a vast number of infectious and non-infectious diseases. Here, we investigated the association of the rs2275913 SNP (G/A) from IL-17A and two forms of susceptibility to CL in Brazil by case-control study. Furthermore, we evaluated the functional relevance of this SNP during the immune response of the host and analyzed its impact in the parasite elimination. Weak associations of A allele with susceptibility to L. braziliensis infection or to symptomatic CL were observed, and a tendency of A allele carriers to be more susceptible to infection and cutaneous disease. Functional analysis of the Th17 cell phenotypes revealed lower frequencies of CD4+ IL-17+ cells in samples of infected people with AA/AG genotypes. Furthermore, people carrying the A allele maintain higher parasite loads, reinforcing the genetic susceptibility findings. This study adds knowledge about the influence of a significant genetic variation on IL-17 promoter on CL pathogenesis, and may contribute to enhance the knowledge about the role of IL-17 in the L. braziliensis infections." @default.
- W2963333482 created "2019-07-30" @default.
- W2963333482 creator A5006526685 @default.
- W2963333482 creator A5011645261 @default.
- W2963333482 creator A5040955790 @default.
- W2963333482 creator A5049210633 @default.
- W2963333482 creator A5064076443 @default.
- W2963333482 creator A5089054320 @default.
- W2963333482 creator A5090820093 @default.
- W2963333482 date "2019-11-01" @default.
- W2963333482 modified "2023-10-16" @default.
- W2963333482 title "Study of association of the rs2275913 IL-17A single nucleotide polymorphism and susceptibility to cutaneous leishmaniasis caused by Leishmania braziliensis" @default.
- W2963333482 cites W1510330021 @default.
- W2963333482 cites W1605146840 @default.
- W2963333482 cites W1732889657 @default.
- W2963333482 cites W1935392444 @default.
- W2963333482 cites W1946855238 @default.
- W2963333482 cites W1963577621 @default.
- W2963333482 cites W1973105583 @default.
- W2963333482 cites W1974781378 @default.
- W2963333482 cites W1988128970 @default.
- W2963333482 cites W1990509955 @default.
- W2963333482 cites W1992357473 @default.
- W2963333482 cites W1997570781 @default.
- W2963333482 cites W2008307260 @default.
- W2963333482 cites W2013507458 @default.
- W2963333482 cites W2018350051 @default.
- W2963333482 cites W2024490058 @default.
- W2963333482 cites W2052219561 @default.
- W2963333482 cites W2054317102 @default.
- W2963333482 cites W2055271346 @default.
- W2963333482 cites W2073404257 @default.
- W2963333482 cites W2084911228 @default.
- W2963333482 cites W2088724702 @default.
- W2963333482 cites W2098842989 @default.
- W2963333482 cites W2101796978 @default.
- W2963333482 cites W2102328887 @default.
- W2963333482 cites W2107915297 @default.
- W2963333482 cites W2111426345 @default.
- W2963333482 cites W2123696939 @default.
- W2963333482 cites W2129617329 @default.
- W2963333482 cites W2141104459 @default.
- W2963333482 cites W2156099634 @default.
- W2963333482 cites W2158116803 @default.
- W2963333482 cites W2159256240 @default.
- W2963333482 cites W2160359623 @default.
- W2963333482 cites W2168057295 @default.
- W2963333482 cites W2243883958 @default.
- W2963333482 cites W2259720540 @default.
- W2963333482 cites W2497043720 @default.
- W2963333482 cites W2523041307 @default.
- W2963333482 cites W2577011855 @default.
- W2963333482 cites W2586175225 @default.
- W2963333482 cites W2637532520 @default.
- W2963333482 cites W2766462773 @default.
- W2963333482 cites W4293247451 @default.
- W2963333482 doi "https://doi.org/10.1016/j.cyto.2019.154784" @default.
- W2963333482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31344596" @default.
- W2963333482 hasPublicationYear "2019" @default.
- W2963333482 type Work @default.
- W2963333482 sameAs 2963333482 @default.
- W2963333482 citedByCount "9" @default.
- W2963333482 countsByYear W29633334822020 @default.
- W2963333482 countsByYear W29633334822021 @default.
- W2963333482 countsByYear W29633334822022 @default.
- W2963333482 countsByYear W29633334822023 @default.
- W2963333482 crossrefType "journal-article" @default.
- W2963333482 hasAuthorship W2963333482A5006526685 @default.
- W2963333482 hasAuthorship W2963333482A5011645261 @default.
- W2963333482 hasAuthorship W2963333482A5040955790 @default.
- W2963333482 hasAuthorship W2963333482A5049210633 @default.
- W2963333482 hasAuthorship W2963333482A5064076443 @default.
- W2963333482 hasAuthorship W2963333482A5089054320 @default.
- W2963333482 hasAuthorship W2963333482A5090820093 @default.
- W2963333482 hasConcept C104317684 @default.
- W2963333482 hasConcept C135763542 @default.
- W2963333482 hasConcept C136764020 @default.
- W2963333482 hasConcept C139275648 @default.
- W2963333482 hasConcept C153209595 @default.
- W2963333482 hasConcept C180754005 @default.
- W2963333482 hasConcept C203014093 @default.
- W2963333482 hasConcept C2776555147 @default.
- W2963333482 hasConcept C2777735729 @default.
- W2963333482 hasConcept C2778702967 @default.
- W2963333482 hasConcept C2781092759 @default.
- W2963333482 hasConcept C41008148 @default.
- W2963333482 hasConcept C54355233 @default.
- W2963333482 hasConcept C67636389 @default.
- W2963333482 hasConcept C71928629 @default.
- W2963333482 hasConcept C86803240 @default.
- W2963333482 hasConcept C8891405 @default.
- W2963333482 hasConceptScore W2963333482C104317684 @default.
- W2963333482 hasConceptScore W2963333482C135763542 @default.
- W2963333482 hasConceptScore W2963333482C136764020 @default.
- W2963333482 hasConceptScore W2963333482C139275648 @default.
- W2963333482 hasConceptScore W2963333482C153209595 @default.
- W2963333482 hasConceptScore W2963333482C180754005 @default.
- W2963333482 hasConceptScore W2963333482C203014093 @default.