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• W2963341906 abstract "Rotaviruses are important pathogens that cause severe gastroenteritis in the young of many animals. The viral polymerase VP1 mediates all stages of viral RNA synthesis, and it requires the core shell protein VP2 for its enzymatic activity. Yet, there are several gaps in knowledge about how VP2 engages and activates VP1. Here, we probed the functional significance of 5 distinct VP2 contact sites on VP1 that were revealed through previous structural studies. Specifically, we engineered alanine amino acid substitutions within each of the 5 VP1 regions and assayed the mutant polymerases for the capacity to synthesize RNA in the presence of VP2 in a test tube. Our results identified residues within 3 of the VP2 contact sites that are critical for robust polymerase activity. These results are important because they enhance the understanding of a key step of the rotavirus replication cycle." @default.
• W2963341906 created "2019-07-30" @default.
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• W2963341906 date "2019-10-15" @default.
• W2963341906 modified "2023-10-16" @default.
• W2963341906 title "<i>In Vitro</i> Double-Stranded RNA Synthesis by Rotavirus Polymerase Mutants with Lesions at Core Shell Contact Sites" @default.
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• W2963341906 doi "https://doi.org/10.1128/jvi.01049-19" @default.
• W2963341906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6798093" @default.
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• W2963341906 hasPublicationYear "2019" @default.
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