FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963353298> ?p ?o ?g. }

• W2963353298 endingPage "R450" @default.
• W2963353298 startingPage "R442" @default.
• W2963353298 abstract "Animals vary tremendously in their capacities to survive anoxia, and the mechanisms responsible are poorly understood. Adult Drosophila melanogaster are rapidly paralyzed and survive up to 12 h of anoxia, whereas larvae vigorously attempt escape but then die if anoxia exceeds 2 h. Here we use nuclear magnetic resonance methods to compare the metabolome of larvae and adult D. melanogaster under normoxic conditions and after various anoxic durations up to 1 h. Glucose increased during anoxia in both larvae and adults, so anoxic death by carbohydrate limitation is unlikely for either stage. Lactate and alanine were the primary anaerobic end products in both adults and larvae. During the first 30 min of anoxia, larvae accumulated anaerobic end products (predominately lactate) at a higher rate, suggesting that larvae may experience greater initial acid-base disruption during anoxic exposures. Adult Drosophila did not possess higher levels of putative protective metabolites; however, these increased during anoxia in adults and decreased in larvae. Metabolites that decreased during anoxia in larvae included mannitol, xylitol, glycerol, betaine, serine, and tyrosine, perhaps due to use as fuels, antioxidants, or binding to denatured proteins. Adults showed significant increases in glycine, taurine, and the polyols glycerol, mannitol, and xylitol, suggesting that adults upregulate protective metabolites to prevent damage. Our results suggest that lower initial metabolic demand due to paralytic hypometabolism and capacities to upregulate protective metabolites may assist the better anoxia tolerance of adult Drosophila." @default.
• W2963353298 created "2019-07-30" @default.
• W2963353298 creator A5036087677 @default.
• W2963353298 creator A5045868352 @default.
• W2963353298 creator A5079415066 @default.
• W2963353298 date "2019-09-01" @default.
• W2963353298 modified "2023-10-14" @default.
• W2963353298 title "Metabolomics of anoxia tolerance in <i>Drosophila melanogaster</i>: evidence against substrate limitation and for roles of protective metabolites and paralytic hypometabolism" @default.
• W2963353298 cites W1028975887 @default.
• W2963353298 cites W1970874044 @default.
• W2963353298 cites W1972232242 @default.
• W2963353298 cites W1977990566 @default.
• W2963353298 cites W1983566905 @default.
• W2963353298 cites W1994237759 @default.
• W2963353298 cites W1995822144 @default.
• W2963353298 cites W2000764190 @default.
• W2963353298 cites W2014213454 @default.
• W2963353298 cites W2019511541 @default.
• W2963353298 cites W2019996442 @default.
• W2963353298 cites W2021829052 @default.
• W2963353298 cites W2023883324 @default.
• W2963353298 cites W2027008357 @default.
• W2963353298 cites W2028097346 @default.
• W2963353298 cites W2045074061 @default.
• W2963353298 cites W2054632547 @default.
• W2963353298 cites W2067219690 @default.
• W2963353298 cites W2067656659 @default.
• W2963353298 cites W2078074521 @default.
• W2963353298 cites W2087189599 @default.
• W2963353298 cites W2092061636 @default.
• W2963353298 cites W2096731539 @default.
• W2963353298 cites W2105293460 @default.
• W2963353298 cites W2116350013 @default.
• W2963353298 cites W2133132988 @default.
• W2963353298 cites W2135684970 @default.
• W2963353298 cites W2139921047 @default.
• W2963353298 cites W2145020809 @default.
• W2963353298 cites W2154996007 @default.
• W2963353298 cites W2157593688 @default.
• W2963353298 cites W2159267296 @default.
• W2963353298 cites W2160760922 @default.
• W2963353298 cites W2167256902 @default.
• W2963353298 cites W2172199758 @default.
• W2963353298 cites W2186441130 @default.
• W2963353298 cites W2254509181 @default.
• W2963353298 cites W2268823210 @default.
• W2963353298 cites W2282548359 @default.
• W2963353298 cites W2331951098 @default.
• W2963353298 cites W2341820027 @default.
• W2963353298 cites W2593050815 @default.
• W2963353298 cites W2757168534 @default.
• W2963353298 cites W2796348852 @default.
• W2963353298 cites W4230096730 @default.
• W2963353298 doi "https://doi.org/10.1152/ajpregu.00389.2018" @default.
• W2963353298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31322917" @default.
• W2963353298 hasPublicationYear "2019" @default.
• W2963353298 type Work @default.
• W2963353298 sameAs 2963353298 @default.
• W2963353298 citedByCount "14" @default.
• W2963353298 countsByYear W29633532982019 @default.
• W2963353298 countsByYear W29633532982020 @default.
• W2963353298 countsByYear W29633532982021 @default.
• W2963353298 countsByYear W29633532982022 @default.
• W2963353298 countsByYear W29633532982023 @default.
• W2963353298 crossrefType "journal-article" @default.
• W2963353298 hasAuthorship W2963353298A5036087677 @default.
• W2963353298 hasAuthorship W2963353298A5045868352 @default.
• W2963353298 hasAuthorship W2963353298A5079415066 @default.
• W2963353298 hasBestOaLocation W29633532981 @default.
• W2963353298 hasConcept C104317684 @default.
• W2963353298 hasConcept C108970007 @default.
• W2963353298 hasConcept C135870905 @default.
• W2963353298 hasConcept C18903297 @default.
• W2963353298 hasConcept C20251656 @default.
• W2963353298 hasConcept C21565614 @default.
• W2963353298 hasConcept C2777477808 @default.
• W2963353298 hasConcept C2777756961 @default.
• W2963353298 hasConcept C2778445172 @default.
• W2963353298 hasConcept C2779701627 @default.
• W2963353298 hasConcept C2780104201 @default.
• W2963353298 hasConcept C42407357 @default.
• W2963353298 hasConcept C5140985 @default.
• W2963353298 hasConcept C515207424 @default.
• W2963353298 hasConcept C55493867 @default.
• W2963353298 hasConcept C60644358 @default.
• W2963353298 hasConcept C62231903 @default.
• W2963353298 hasConcept C86803240 @default.
• W2963353298 hasConceptScore W2963353298C104317684 @default.
• W2963353298 hasConceptScore W2963353298C108970007 @default.
• W2963353298 hasConceptScore W2963353298C135870905 @default.
• W2963353298 hasConceptScore W2963353298C18903297 @default.
• W2963353298 hasConceptScore W2963353298C20251656 @default.
• W2963353298 hasConceptScore W2963353298C21565614 @default.
• W2963353298 hasConceptScore W2963353298C2777477808 @default.
• W2963353298 hasConceptScore W2963353298C2777756961 @default.
• W2963353298 hasConceptScore W2963353298C2778445172 @default.
• W2963353298 hasConceptScore W2963353298C2779701627 @default.
• W2963353298 hasConceptScore W2963353298C2780104201 @default.

• next