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- W2963385366 endingPage "586" @default.
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- W2963385366 abstract "Almost half of patients with chronic granulomatous disease (CGD) suffer from gastrointestinal (GI) inflammation, the pathogenesis of which is complex and multifactorial. As a result, the management of CGD-associated GI inflammation remains challenging due to its chronicity and difficulty in managing the simultaneous need for immunomodulation with increased susceptibility to infection. In order to contextualize prospective treatment interventions for CGD-associated GI inflammation, we have reviewed the clinical presentation, pathogenesis and current management of this disease. Increased understanding of the role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex 2 (NOX2)-derived reactive oxygen species (ROS) in inflammatory bowel disease (IBD) will likely reveal novel targets for therapeutic intervention." @default.
- W2963385366 created "2019-07-30" @default.
- W2963385366 creator A5056552919 @default.
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- W2963385366 date "2019-01-01" @default.
- W2963385366 modified "2023-10-18" @default.
- W2963385366 title "Gastrointestinal Complications in Chronic Granulomatous Disease" @default.
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- W2963385366 doi "https://doi.org/10.1007/978-1-4939-9424-3_34" @default.
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