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- W2963452481 endingPage "11645" @default.
- W2963452481 startingPage "11641" @default.
- W2963452481 abstract "Abstract Ibuprofen was prepared from an inactive and inexpensive p ‐xylene by three‐step flow functionalizations through chemoselective metalations of benzyl positions in sequence using an in situ generated LICKOR‐type superbase. The flow approach in the microreactor facilitated the comprehensive exploration of over 100 conditions in the first‐step reaction by varying concentrations, temperatures, solvents, and equivalents of reagents, enabling optimal conditions to be found with 95 % yield by significantly suppressing the formation of byproducts, followed by the second C−H metalation step in 95 % yield. Moreover, gram‐scale synthesis of ibuprofen in the final step was achieved by biphasic flow reaction of solution‐phase intermediate with CO 2 , isolating 2.3 g for 10 min of operation time." @default.
- W2963452481 created "2019-07-30" @default.
- W2963452481 creator A5015468360 @default.
- W2963452481 creator A5018366863 @default.
- W2963452481 creator A5065912208 @default.
- W2963452481 date "2019-08-20" @default.
- W2963452481 modified "2023-09-26" @default.
- W2963452481 title "From <i>p</i> ‐Xylene to Ibuprofen in Flow: Three‐Step Synthesis by a Unified Sequence of Chemoselective C−H Metalations" @default.
- W2963452481 cites W1006037363 @default.
- W2963452481 cites W1608249596 @default.
- W2963452481 cites W1731080298 @default.
- W2963452481 cites W1840182658 @default.
- W2963452481 cites W1919898203 @default.
- W2963452481 cites W1937018166 @default.
- W2963452481 cites W1954905398 @default.
- W2963452481 cites W1955907314 @default.
- W2963452481 cites W1971594134 @default.
- W2963452481 cites W1983397847 @default.
- W2963452481 cites W2006963618 @default.
- W2963452481 cites W2013017521 @default.
- W2963452481 cites W2018605464 @default.
- W2963452481 cites W2024859618 @default.
- W2963452481 cites W2027380034 @default.
- W2963452481 cites W2031605136 @default.
- W2963452481 cites W2032100959 @default.
- W2963452481 cites W2038266933 @default.
- W2963452481 cites W2045696930 @default.
- W2963452481 cites W2062467969 @default.
- W2963452481 cites W2067616917 @default.
- W2963452481 cites W2092193404 @default.
- W2963452481 cites W2095693629 @default.
- W2963452481 cites W2097958524 @default.
- W2963452481 cites W2099852092 @default.
- W2963452481 cites W2110548073 @default.
- W2963452481 cites W2112758539 @default.
- W2963452481 cites W2121707544 @default.
- W2963452481 cites W2122075967 @default.
- W2963452481 cites W2125978211 @default.
- W2963452481 cites W2126451255 @default.
- W2963452481 cites W2129661423 @default.
- W2963452481 cites W2133101805 @default.
- W2963452481 cites W2136082411 @default.
- W2963452481 cites W2136180511 @default.
- W2963452481 cites W2136313112 @default.
- W2963452481 cites W2136570285 @default.
- W2963452481 cites W2141958418 @default.
- W2963452481 cites W2144094346 @default.
- W2963452481 cites W2145550978 @default.
- W2963452481 cites W2146989470 @default.
- W2963452481 cites W2151054602 @default.
- W2963452481 cites W2151603352 @default.
- W2963452481 cites W2159811749 @default.
- W2963452481 cites W2161625034 @default.
- W2963452481 cites W2162105003 @default.
- W2963452481 cites W2162798590 @default.
- W2963452481 cites W2164939987 @default.
- W2963452481 cites W2168117363 @default.
- W2963452481 cites W2202950832 @default.
- W2963452481 cites W2258776124 @default.
- W2963452481 cites W2291845424 @default.
- W2963452481 cites W2296882401 @default.
- W2963452481 cites W2321992586 @default.
- W2963452481 cites W2322255728 @default.
- W2963452481 cites W2324378914 @default.
- W2963452481 cites W2334592091 @default.
- W2963452481 cites W2341727092 @default.
- W2963452481 cites W2346720530 @default.
- W2963452481 cites W2399856492 @default.
- W2963452481 cites W2467718585 @default.
- W2963452481 cites W2503796655 @default.
- W2963452481 cites W2514264187 @default.
- W2963452481 cites W2572621360 @default.
- W2963452481 cites W2603474936 @default.
- W2963452481 cites W2615781317 @default.
- W2963452481 cites W2615964204 @default.
- W2963452481 cites W2621108245 @default.
- W2963452481 cites W2779047742 @default.
- W2963452481 cites W2789689307 @default.
- W2963452481 cites W2792874657 @default.
- W2963452481 cites W2797275648 @default.
- W2963452481 cites W2804131187 @default.
- W2963452481 cites W2883924372 @default.
- W2963452481 cites W2891182990 @default.
- W2963452481 cites W2893512291 @default.
- W2963452481 cites W2900713578 @default.
- W2963452481 cites W2901670787 @default.
- W2963452481 cites W4232323024 @default.
- W2963452481 cites W4232606813 @default.
- W2963452481 cites W4233399748 @default.
- W2963452481 cites W4233548096 @default.
- W2963452481 cites W4235447197 @default.
- W2963452481 cites W4236746908 @default.
- W2963452481 cites W4243829483 @default.
- W2963452481 cites W4245410896 @default.
- W2963452481 cites W4245476047 @default.
- W2963452481 cites W4246043814 @default.
- W2963452481 cites W4247366581 @default.
- W2963452481 cites W4252754407 @default.