Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963461330> ?p ?o ?g. }
- W2963461330 abstract "SUMMARY Transforming growth factor (TGF)-β plays crucial roles in differentiation of dendritic cells (DC). However, molecular mechanisms how TGF-β regulates DC differentiation remain largely unknown. Here, we show that selective repression of one of the TGF-β receptor-regulated SMADs (R-SMADs), SMAD3 directs conventional DC (cDC) differentiation, whereas maintenance of SMAD3 is indispensable for plasmacytoid DC (pDC) differentiation. Expression of SMAD3 was specifically downregulated in CD115 + common DC progenitor (CDP), pre-cDCs and cDCs. SMAD3 deficient mice showed a significant reduction in pre-pDCs and pDCs with increased CDP, pre-cDCs and cDCs. SMAD3 upregulated the pDC-related genes: SPI-B, E2-2 and IKAROS, while it repressed FLT3 and the cDC-related genes: IRF4 and ID2. STAT3 and a SMAD transcriptional co-repressor, c-SKI repressed SMAD3 for cDC differentiation, whereas canonical SMAD-mediated TGF-β signalling maintained SMAD3 for pDC differentiation. Thus, SMAD3 is the pivotal determinant to bifurcate cDC and pDC differentiation in the steady-state condition." @default.
- W2963461330 created "2019-07-30" @default.
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- W2963461330 date "2019-07-25" @default.
- W2963461330 modified "2023-10-03" @default.
- W2963461330 title "SMAD3 Determines Conventional versus Plasmacytoid Dendritic Cell Fates" @default.
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- W2963461330 cites W1971093570 @default.
- W2963461330 cites W1972157351 @default.
- W2963461330 cites W1973564464 @default.
- W2963461330 cites W1975820522 @default.
- W2963461330 cites W1981743414 @default.
- W2963461330 cites W1982832618 @default.
- W2963461330 cites W1984850507 @default.
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- W2963461330 cites W2041267913 @default.
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- W2963461330 cites W2054581136 @default.
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- W2963461330 cites W2101595031 @default.
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- W2963461330 doi "https://doi.org/10.1101/715060" @default.
- W2963461330 hasPublicationYear "2019" @default.
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