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- W2963650159 abstract "Osteoarthritis (OA) is a common, poly-etiological disease of the joints, the occurrence and development of which is associated with a number of genetic, endogenous (hormonal balance, immune disorders, oxidative stress) and exogenous factors (trauma, overload). The combination of metabolic syndrome (MS) and OA is one of the most pressing medical and social issues for healthcare today. This is due to both their extremely high prevalence and high comorbidity with other conditions and diseases that have a significant impact on the quality of life of patients. The aim of our work was to study the pleurotropic effect of rosuvastatin on the pain intense and disease intensity in the course of OA in patients with comorbid MS, as well as its effect on blood pressure (BP), heart rate (HR), level of anthropometric indicators and lipidogram indicators. 30 patients were examined for OA and MS. Patients were divided into two age-matched groups. Rosuvastatin was prescribed to group I (n = 15) in a dose of 20 mg once a day for 12 days. The criteria for assessing the therapy efficacy included pain severity, articular and anthropometric parameters, laboratory and instrumental parameters, the level of quality of life. Patients were examined twice: before the therapy and on the day 12 of the therapy. It has been established that the rozuvastatin prescribed for this category of patients can reduce pain, improve joint function, lower the intensity of the disease and improve the quality of life of patients. In addition, rozustastatin does not affect the level of systolic and diastolic blood pressure, and can be prescribed for patients with concomitant arterial hypertension." @default.
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- W2963650159 date "2019-07-19" @default.
- W2963650159 modified "2023-09-26" @default.
- W2963650159 title "MODERN APPROACH TOWARDS THE TREATMENT OF COMORBID PATHOLOGY" @default.
- W2963650159 doi "https://doi.org/10.31718/2077-1096.19.2.12" @default.
- W2963650159 hasPublicationYear "2019" @default.
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