Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963694326> ?p ?o ?g. }
- W2963694326 endingPage "3955" @default.
- W2963694326 startingPage "3939" @default.
- W2963694326 abstract "Background and Purpose Osteoarthritic pain is a chronic disabling condition lacking effective treatment. Continuous use of opioid drugs during osteoarthritic pain induces tolerance and may result in dose escalation and abuse. Sigma‐1 (σ1) receptors, a chaperone expressed in key areas for pain control, modulates μ‐opioid receptor activity and represents a promising target to tackle these problems. The present study investigates the efficacy of the σ1 receptor antagonist E‐52862 to inhibit pain sensitization, morphine tolerance, and associated electrophysiological and molecular changes in a murine model of osteoarthritic pain. Experimental Approach Mice received an intra‐knee injection of monoiodoacetate followed by 14‐day treatment with E‐52862, morphine, or vehicle, and mechanical sensitivity was assessed before and after the daily doses. Key Results Monoiodoacetate‐injected mice developed persistent mechanical hypersensitivity, which was dose‐dependently inhibited by E‐52862. Mechanical thresholds assessed before the daily E‐52862 dose showed gradual recovery, reaching complete restoration by the end of the treatment. When repeated treatment started 15 days after knee injury, E‐52862 produced enhanced short‐term analgesia, but recovery to baseline threshold was slower. Both a σ1 receptor agonist and a μ receptor antagonist blocked the analgesic effects of E‐52862. An acute, sub‐effective dose of E‐52862 restored morphine analgesia in opioid‐tolerant mice. Moreover, E‐52862 abolished spinal sensitization in osteoarthritic mice and inhibited pain‐related molecular changes. Conclusion and Implications These findings show dual effects of σ1 receptor antagonism alleviating both short‐ and long‐lasting antinociception during chronic osteoarthritis pain. They identify E‐52862 as a promising pharmacological agent to treat chronic pain and avoid opioid tolerance." @default.
- W2963694326 created "2019-07-30" @default.
- W2963694326 creator A5005470954 @default.
- W2963694326 creator A5010214822 @default.
- W2963694326 creator A5026686227 @default.
- W2963694326 creator A5026889440 @default.
- W2963694326 creator A5048779913 @default.
- W2963694326 creator A5076342734 @default.
- W2963694326 creator A5077189232 @default.
- W2963694326 creator A5079208975 @default.
- W2963694326 date "2019-09-12" @default.
- W2963694326 modified "2023-10-15" @default.
- W2963694326 title "Sigma‐1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain" @default.
- W2963694326 cites W1203304228 @default.
- W2963694326 cites W1487036716 @default.
- W2963694326 cites W1501096191 @default.
- W2963694326 cites W1593555249 @default.
- W2963694326 cites W1839745439 @default.
- W2963694326 cites W1908253227 @default.
- W2963694326 cites W1940688833 @default.
- W2963694326 cites W1965148914 @default.
- W2963694326 cites W1966145021 @default.
- W2963694326 cites W1967113556 @default.
- W2963694326 cites W1967384561 @default.
- W2963694326 cites W1968514708 @default.
- W2963694326 cites W1972242861 @default.
- W2963694326 cites W1972592953 @default.
- W2963694326 cites W1984981145 @default.
- W2963694326 cites W1992064492 @default.
- W2963694326 cites W1995552213 @default.
- W2963694326 cites W1998878665 @default.
- W2963694326 cites W2003642068 @default.
- W2963694326 cites W2003785826 @default.
- W2963694326 cites W2005544002 @default.
- W2963694326 cites W2008800555 @default.
- W2963694326 cites W2017065497 @default.
- W2963694326 cites W2017730736 @default.
- W2963694326 cites W2019079031 @default.
- W2963694326 cites W2019972898 @default.
- W2963694326 cites W2024734357 @default.
- W2963694326 cites W2048890215 @default.
- W2963694326 cites W2058613090 @default.
- W2963694326 cites W2059143513 @default.
- W2963694326 cites W2059583297 @default.
- W2963694326 cites W2070393781 @default.
- W2963694326 cites W2071441738 @default.
- W2963694326 cites W2071816115 @default.
- W2963694326 cites W2076103145 @default.
- W2963694326 cites W2076819587 @default.
- W2963694326 cites W2082790399 @default.
- W2963694326 cites W2092095392 @default.
- W2963694326 cites W2094044265 @default.
- W2963694326 cites W2107277218 @default.
- W2963694326 cites W2115369213 @default.
- W2963694326 cites W2123212921 @default.
- W2963694326 cites W2124673849 @default.
- W2963694326 cites W2129373115 @default.
- W2963694326 cites W2131087015 @default.
- W2963694326 cites W2140486309 @default.
- W2963694326 cites W2161463814 @default.
- W2963694326 cites W2167613032 @default.
- W2963694326 cites W2172201406 @default.
- W2963694326 cites W2182476681 @default.
- W2963694326 cites W2199823879 @default.
- W2963694326 cites W2287944910 @default.
- W2963694326 cites W2317715564 @default.
- W2963694326 cites W2328689172 @default.
- W2963694326 cites W2514166900 @default.
- W2963694326 cites W2765684626 @default.
- W2963694326 cites W2767041448 @default.
- W2963694326 cites W2767055120 @default.
- W2963694326 cites W2771328536 @default.
- W2963694326 cites W2791419854 @default.
- W2963694326 cites W2791425609 @default.
- W2963694326 cites W2792530460 @default.
- W2963694326 cites W2805853948 @default.
- W2963694326 cites W2909584163 @default.
- W2963694326 cites W2916844163 @default.
- W2963694326 cites W2943583379 @default.
- W2963694326 doi "https://doi.org/10.1111/bph.14794" @default.
- W2963694326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6811737" @default.
- W2963694326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31332781" @default.
- W2963694326 hasPublicationYear "2019" @default.
- W2963694326 type Work @default.
- W2963694326 sameAs 2963694326 @default.
- W2963694326 citedByCount "24" @default.
- W2963694326 countsByYear W29636943262020 @default.
- W2963694326 countsByYear W29636943262021 @default.
- W2963694326 countsByYear W29636943262022 @default.
- W2963694326 countsByYear W29636943262023 @default.
- W2963694326 crossrefType "journal-article" @default.
- W2963694326 hasAuthorship W2963694326A5005470954 @default.
- W2963694326 hasAuthorship W2963694326A5010214822 @default.
- W2963694326 hasAuthorship W2963694326A5026686227 @default.
- W2963694326 hasAuthorship W2963694326A5026889440 @default.
- W2963694326 hasAuthorship W2963694326A5048779913 @default.
- W2963694326 hasAuthorship W2963694326A5076342734 @default.
- W2963694326 hasAuthorship W2963694326A5077189232 @default.