Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963722431> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2963722431 abstract "The intestinal microbiota is known to play a pivotal role in the development of the host immune system and in the maintenance of host homeostasis by suppressing responses to pathogens and by enforcing the integrity of the barrier functions of the gut mucosa. Therefore, dysbiosis, described as the deviation in the composition and function of the gut microbiome, may affect the human health status and disease susceptibility. Different pathologies have been associated with changes in the composition of the intestinal microbiota, however, whether dysbiosis is a contributing factor or a consequence of the disease is still uncertain. Cirrhosis is considered an important public health problem and is a progressive and chronic condition characterised by inflammation associated with dying hepatic cells and fibrosis, which lead to cellular dysfunction and portal hypertension. It is known that gut microbiota plays an important role in cirrhosis, bacterial translocation being a key factor in the pathogenesis and its complications. Bacterial translocation is defined as the migration of viable bacteria or their products from the gastrointestinal tract to mesenteric lymph nodes and other extra-intestinal sites. Alterations of the normal intestinal microbiota, impairment of the immune status, and damage of the gut barrier that increases permeability, are the different mechanisms involved in translocation. It is hypothesised that alterations of microbial composition could favour bacterial translocation and activate an immune response with the consequent release of cytokines and an inflammatory response creating a feedback in which bacterial translocation promotes its own causative mechanisms. Since bacterial translocation has not been extensively studied in humans and very little is known about the microbiome of extra-intestinal sites in patients with cirrhosis, we performed two studies in both humans and animals, to better understand the relevance of this phenomenon in liver cirrhosis. In the first study, we conclude that serum and ascitic fluid of patients with cirrhosis contain a complex and specific microbial community. Moreover, we propose that alteration of the serum and faecal microbiome composition could be considered indicators of cirrhosis progression. In the second study, we conclude that microbiome changes in intestinal sites are associated with microbial shifts in the mesenteric lymph nodes as well as an increase in cytokine production, providing further evidence of the role of the gut-liverimmunity axis in the progression of cirrhosis." @default.
- W2963722431 created "2019-07-30" @default.
- W2963722431 creator A5085378400 @default.
- W2963722431 date "2018-10-03" @default.
- W2963722431 modified "2023-09-22" @default.
- W2963722431 title "Study of the alterations in the intestinal and extra-intestinal microbiome in rats and humans throughout the progression of cirrhosis" @default.
- W2963722431 hasPublicationYear "2018" @default.
- W2963722431 type Work @default.
- W2963722431 sameAs 2963722431 @default.
- W2963722431 citedByCount "0" @default.
- W2963722431 crossrefType "dissertation" @default.
- W2963722431 hasAuthorship W2963722431A5085378400 @default.
- W2963722431 hasConcept C104317684 @default.
- W2963722431 hasConcept C126322002 @default.
- W2963722431 hasConcept C138626823 @default.
- W2963722431 hasConcept C142724271 @default.
- W2963722431 hasConcept C143121216 @default.
- W2963722431 hasConcept C203014093 @default.
- W2963722431 hasConcept C2776914184 @default.
- W2963722431 hasConcept C2777165150 @default.
- W2963722431 hasConcept C2777214474 @default.
- W2963722431 hasConcept C2779134260 @default.
- W2963722431 hasConcept C2779237934 @default.
- W2963722431 hasConcept C2780942790 @default.
- W2963722431 hasConcept C2781071285 @default.
- W2963722431 hasConcept C2781077229 @default.
- W2963722431 hasConcept C3019368612 @default.
- W2963722431 hasConcept C529295009 @default.
- W2963722431 hasConcept C539455810 @default.
- W2963722431 hasConcept C54355233 @default.
- W2963722431 hasConcept C60644358 @default.
- W2963722431 hasConcept C71924100 @default.
- W2963722431 hasConcept C86803240 @default.
- W2963722431 hasConcept C8891405 @default.
- W2963722431 hasConceptScore W2963722431C104317684 @default.
- W2963722431 hasConceptScore W2963722431C126322002 @default.
- W2963722431 hasConceptScore W2963722431C138626823 @default.
- W2963722431 hasConceptScore W2963722431C142724271 @default.
- W2963722431 hasConceptScore W2963722431C143121216 @default.
- W2963722431 hasConceptScore W2963722431C203014093 @default.
- W2963722431 hasConceptScore W2963722431C2776914184 @default.
- W2963722431 hasConceptScore W2963722431C2777165150 @default.
- W2963722431 hasConceptScore W2963722431C2777214474 @default.
- W2963722431 hasConceptScore W2963722431C2779134260 @default.
- W2963722431 hasConceptScore W2963722431C2779237934 @default.
- W2963722431 hasConceptScore W2963722431C2780942790 @default.
- W2963722431 hasConceptScore W2963722431C2781071285 @default.
- W2963722431 hasConceptScore W2963722431C2781077229 @default.
- W2963722431 hasConceptScore W2963722431C3019368612 @default.
- W2963722431 hasConceptScore W2963722431C529295009 @default.
- W2963722431 hasConceptScore W2963722431C539455810 @default.
- W2963722431 hasConceptScore W2963722431C54355233 @default.
- W2963722431 hasConceptScore W2963722431C60644358 @default.
- W2963722431 hasConceptScore W2963722431C71924100 @default.
- W2963722431 hasConceptScore W2963722431C86803240 @default.
- W2963722431 hasConceptScore W2963722431C8891405 @default.
- W2963722431 hasLocation W29637224311 @default.
- W2963722431 hasOpenAccess W2963722431 @default.
- W2963722431 hasPrimaryLocation W29637224311 @default.
- W2963722431 hasRelatedWork W2059967908 @default.
- W2963722431 hasRelatedWork W2075363951 @default.
- W2963722431 hasRelatedWork W2144171535 @default.
- W2963722431 hasRelatedWork W2149848289 @default.
- W2963722431 hasRelatedWork W2359024150 @default.
- W2963722431 hasRelatedWork W2513374507 @default.
- W2963722431 hasRelatedWork W2604956414 @default.
- W2963722431 hasRelatedWork W2727171335 @default.
- W2963722431 hasRelatedWork W2789714843 @default.
- W2963722431 hasRelatedWork W2795241760 @default.
- W2963722431 hasRelatedWork W2900571562 @default.
- W2963722431 hasRelatedWork W2922620113 @default.
- W2963722431 hasRelatedWork W2923361594 @default.
- W2963722431 hasRelatedWork W2969136014 @default.
- W2963722431 hasRelatedWork W3090860613 @default.
- W2963722431 hasRelatedWork W3162909969 @default.
- W2963722431 hasRelatedWork W3171136206 @default.
- W2963722431 hasRelatedWork W3178529644 @default.
- W2963722431 hasRelatedWork W3190889543 @default.
- W2963722431 hasRelatedWork W3196757718 @default.
- W2963722431 isParatext "false" @default.
- W2963722431 isRetracted "false" @default.
- W2963722431 magId "2963722431" @default.
- W2963722431 workType "dissertation" @default.