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- W2963723786 abstract "In a group sequential clinical trial, accumulated data are analyzed at numerous time points to allow early decisions about a hypothesis of interest. These designs have historically been recommended for their ethical, administrative, and economic benefits. In this article, we first discuss a collection of new commands for computing the stopping boundaries and required group size of various classical group sequential designs, assuming a normally distributed outcome variable. Then, we demonstrate how the performance of several designs can be compared graphically." @default.
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- W2963723786 date "2018-06-01" @default.
- W2963723786 modified "2023-09-23" @default.
- W2963723786 title "Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables" @default.
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- W2963723786 doi "https://doi.org/10.1177/1536867x1801800208" @default.
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