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• W2963761736 abstract "Objective Antipsychotic‐induced weight gain (Ai WG ) is a debilitating adverse effect of most antipsychotics. First‐episode psychosis patients are particularly vulnerable to the detrimental consequences of Ai WG . Amisulpride has good efficacy and tolerability. We here aimed to identify the phenotypic factors associated with amisulpride‐induced weight gain in first‐episode psychosis patients. Method Data were collected from the Optimization of Treatment and Management of Schizophrenia in Europe trial. Multivariable regression models with various phenotypic variables ( N = 305) were performed with absolute Ai WG and clinically relevant Ai WG (≥7% Ai WG ) as outcomes. Results Four weeks of amisulpride treatment increased body weight from 69.7 to 72.4 kg ( P < 0.001). In the regression model of absolute Ai WG , unemployment ( β = 0.94, P = 0.016), younger age ( β = −0.07, P = 0.031) and absence of current comorbid major depression disorder ( β = −1.61, P = 0.034) were positively associated with absolute Ai WG . In the regression model of clinically relevant Ai WG , unemployment ( OR = 2.83, P = 0.001), schizophreniform disorder ( OR = 2.00, P = 0.025) and low baseline weight ( OR = 0.97, P = 0.032) increased the likelihood of clinically relevant Ai WG . Conclusions Clinicians prescribing amisulpride should consider the relatively high susceptibility to Ai WG in unemployed first‐episode patients with psychosis, in particular young subjects with a diagnosis of schizophreniform disorder. We advise to carefully monitor these patients and, when needed, implement weight‐reducing strategies." @default.
• W2963761736 created "2019-07-30" @default.
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• W2963761736 date "2019-08-02" @default.
• W2963761736 modified "2023-10-16" @default.
• W2963761736 title "Phenotypic factors associated with amisulpride‐induced weight gain in first‐episode psychosis patients (from the <scp>OPT</scp>iMi<scp>SE</scp> cohort)" @default.
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• W2963761736 doi "https://doi.org/10.1111/acps.13074" @default.
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