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• W2963841843 abstract "Oxidative stress is recognized as free radical dyshomeostasis, which has damaging effects on proteins, lipids and DNA. However, during cell differentiation and proliferation and other normal physiological processes, free radicals play a pivotal role in message transmission and are considered important messengers. Organisms maintain free radical homeostasis through a sophisticated regulatory system in which these 2-faced molecules play appropriate roles under physiological and pathological conditions. Reactive oxygen species (ROS), including a large number of free radicals, act as redox signalling molecules in essential cellular signalling pathways, including cell differentiation and proliferation. However, excessive ROS levels can induce oxidative stress, which is an important risk factor for diabetes, cancer and cardiovascular disease. An overall comprehensive understanding of ROS is beneficial for understanding the pathogenesis of certain diseases and finding new therapeutic treatments. This review primarily focuses on ROS cellular localization, sources, chemistry and molecular targets to determine how to distinguish between the roles of ROS as messengers and in oxidative stress." @default.
• W2963841843 created "2019-07-30" @default.
• W2963841843 creator A5026935732 @default.
• W2963841843 creator A5062368574 @default.
• W2963841843 date "2019-08-08" @default.
• W2963841843 modified "2023-10-17" @default.
• W2963841843 title "Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties" @default.
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