FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963877029> ?p ?o ?g. }

• W2963877029 abstract "Abstract The accumulation of advanced glycation end products (AGEs) have been implicated in the development and progression of diabetic kidney disease (DKD). There has been interest in investigating the potential of AGE clearance receptors, such as oligosaccharyltransferase-48kDa subunit (OST48) to prevent the detrimental effects of excess AGE accumulation seen in the diabetic kidney. Here the objective of the study was to increase the expression of OST48 to examine if this slowed the development of DKD by facilitating the clearance of AGEs. Groups of 8-week-old heterozygous knock-in male mice (n=9-12/group) over-expressing the gene encoding for OST48, dolichyl-diphosphooligosaccharide-protein glycosyltransferase ( DDOST +/-) and litter mate controls were randomised to either (i) no diabetes or (ii) diabetes induced via multiple low-dose streptozotocin and followed for 24 weeks. By the study end, global over expression of OST48 increased glomerular OST48. This facilitated greater renal excretion of AGEs but did not affect circulating or renal AGE concentrations. Diabetes resulted in kidney damage including lower glomerular filtration rate, albuminuria, glomerulosclerosis and tubulointerstitial fibrosis. In diabetic mice, tubulointerstitial fibrosis was further exacerbated by global increases in OST48. There was significantly insulin effectiveness, increased acute insulin secretion, fasting insulin concentrations and AUC insulin observed during glucose tolerance testing in diabetic mice with global elevations in OST48 when compared to diabetic wild-type littermates. Overall, this study suggested that despite facilitating urinaryrenal AGE clearance, there were no benefits observed on kidney functional and structural parameters in diabetes afforded by globally increasing OST48 expression. However, the improvements in insulin secretion seen in diabetic mice with global over-expression of OST48 and their dissociation from effects on kidney function warrant future investigation." @default.
• W2963877029 created "2019-07-30" @default.
• W2963877029 creator A5003121500 @default.
• W2963877029 creator A5011660710 @default.
• W2963877029 creator A5050391645 @default.
• W2963877029 creator A5053658893 @default.
• W2963877029 creator A5056861160 @default.
• W2963877029 creator A5057346686 @default.
• W2963877029 creator A5066865916 @default.
• W2963877029 creator A5072552257 @default.
• W2963877029 creator A5080285308 @default.
• W2963877029 creator A5084700090 @default.
• W2963877029 creator A5090417075 @default.
• W2963877029 creator A5091809687 @default.
• W2963877029 date "2019-07-22" @default.
• W2963877029 modified "2023-09-26" @default.
• W2963877029 title "Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion" @default.
• W2963877029 cites W1481324852 @default.
• W2963877029 cites W1524829680 @default.
• W2963877029 cites W1545025889 @default.
• W2963877029 cites W1570583414 @default.
• W2963877029 cites W1963877784 @default.
• W2963877029 cites W1965220977 @default.
• W2963877029 cites W1968299608 @default.
• W2963877029 cites W1969225712 @default.
• W2963877029 cites W1971069803 @default.
• W2963877029 cites W1974180544 @default.
• W2963877029 cites W1975646168 @default.
• W2963877029 cites W1988888976 @default.
• W2963877029 cites W1994252489 @default.
• W2963877029 cites W1995375315 @default.
• W2963877029 cites W2010036181 @default.
• W2963877029 cites W2020985397 @default.
• W2963877029 cites W2021458684 @default.
• W2963877029 cites W2030022427 @default.
• W2963877029 cites W2032748552 @default.
• W2963877029 cites W2044010777 @default.
• W2963877029 cites W2055416829 @default.
• W2963877029 cites W2056976690 @default.
• W2963877029 cites W2061906058 @default.
• W2963877029 cites W2062273929 @default.
• W2963877029 cites W2071738821 @default.
• W2963877029 cites W2081193499 @default.
• W2963877029 cites W2089142647 @default.
• W2963877029 cites W2092612186 @default.
• W2963877029 cites W2097225786 @default.
• W2963877029 cites W2101508556 @default.
• W2963877029 cites W2104082850 @default.
• W2963877029 cites W2113417828 @default.
• W2963877029 cites W2114165700 @default.
• W2963877029 cites W2121257659 @default.
• W2963877029 cites W2126926134 @default.
• W2963877029 cites W2127218697 @default.
• W2963877029 cites W2130189158 @default.
• W2963877029 cites W2133462638 @default.
• W2963877029 cites W2135816525 @default.
• W2963877029 cites W2140180120 @default.
• W2963877029 cites W2141713511 @default.
• W2963877029 cites W2143201143 @default.
• W2963877029 cites W2145632481 @default.
• W2963877029 cites W2147453419 @default.
• W2963877029 cites W2150112427 @default.
• W2963877029 cites W2153558667 @default.
• W2963877029 cites W2153605160 @default.
• W2963877029 cites W2158217645 @default.
• W2963877029 cites W2164438863 @default.
• W2963877029 cites W2167279371 @default.
• W2963877029 cites W2171294019 @default.
• W2963877029 cites W2313151616 @default.
• W2963877029 cites W2416932296 @default.
• W2963877029 cites W2755654621 @default.
• W2963877029 cites W2762823215 @default.
• W2963877029 cites W2769264260 @default.
• W2963877029 cites W2769932083 @default.
• W2963877029 doi "https://doi.org/10.1101/710558" @default.
• W2963877029 hasPublicationYear "2019" @default.
• W2963877029 type Work @default.
• W2963877029 sameAs 2963877029 @default.
• W2963877029 citedByCount "0" @default.
• W2963877029 crossrefType "posted-content" @default.
• W2963877029 hasAuthorship W2963877029A5003121500 @default.
• W2963877029 hasAuthorship W2963877029A5011660710 @default.
• W2963877029 hasAuthorship W2963877029A5050391645 @default.
• W2963877029 hasAuthorship W2963877029A5053658893 @default.
• W2963877029 hasAuthorship W2963877029A5056861160 @default.
• W2963877029 hasAuthorship W2963877029A5057346686 @default.
• W2963877029 hasAuthorship W2963877029A5066865916 @default.
• W2963877029 hasAuthorship W2963877029A5072552257 @default.
• W2963877029 hasAuthorship W2963877029A5080285308 @default.
• W2963877029 hasAuthorship W2963877029A5084700090 @default.
• W2963877029 hasAuthorship W2963877029A5090417075 @default.
• W2963877029 hasAuthorship W2963877029A5091809687 @default.
• W2963877029 hasBestOaLocation W29638770291 @default.
• W2963877029 hasConcept C126322002 @default.
• W2963877029 hasConcept C134018914 @default.
• W2963877029 hasConcept C147990577 @default.
• W2963877029 hasConcept C159641895 @default.
• W2963877029 hasConcept C2776174234 @default.
• W2963877029 hasConcept C2777390665 @default.
• W2963877029 hasConcept C2778653478 @default.

• next