FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963907576> ?p ?o ?g. }

• W2963907576 endingPage "1386" @default.
• W2963907576 startingPage "1380" @default.
• W2963907576 abstract "We determined if a high-intensity aerobic exercise program would be safe, improve expected fitness and clinical outcomes, and alter exploratory phosphorous magnetic resonance spectroscopy (P MRS) outcomes in persons with multiple sclerosis (PwMS).This open-label prospective pilot study compared two cohorts of ambulatory PwMS matched for age, sex and V˙O2max. Cohorts underwent 8 wk of high-intensity aerobic exercise (MS-Ex, n = 10) or guided stretching (MS-Ctr, n = 7). Aerobic exercise consisted of four 30-min sessions per week while maintaining ≥70% maximal HR. Changes in cardiorespiratory fitness, clinical outcomes, and P MRS of tibialis anterior (TA) muscle and brain were compared. Cross-sectional P MRS comparisons were made between all MS participants and a separate matched healthy control population.The MS-Ex cohort achieved target increases in V˙O2max (mean, +12.7%; P = <0.001, between-group improvement, P = 0.03). One participant was withdrawn for exercise-induced syncope. The MS-Ex cohort had within-group improvements in fat mass (-5.8%; P = 0.04), lean muscle mass (+2.6%; P = 0.02), Symbol Digit Modalities Test (+15.1%; P = 0.04), and cognitive subscore of the Modified Fatigue Impact Scale (-26%; P = 0.03), whereas only the physical subscore of the Modified Fatigue Impact Scale improved in MS-Ctr (-16.1%; P = 0.007). P MRS revealed significant within-group increases in MS-Ex participants in TA rate constant of phosphocreatine (PCr) recovery (+31.5%; P = 0.03) and adenosine triphosphate/PCr (+3.2%; P = 0.01), and near significant between-group increases in TA PCr recovery rate constant (P = 0.05) but no significant changes in brain P MRS after exercise. Cross-sectional differences existed between MS and healthy control brain PCr/inorganic phosphate (4.61 ± 0.44, 3.93 ± 0.19; P = 0.0019).High-intensity aerobic exercise in PwMS improved expected cardiorespiratory and clinical outcomes but provoked one serious adverse event. The P MRS may serve to explore underlying mechanisms by which aerobic exercise exerts cerebral benefits." @default.
• W2963907576 created "2019-07-30" @default.
• W2963907576 creator A5000311910 @default.
• W2963907576 creator A5016561324 @default.
• W2963907576 creator A5035943065 @default.
• W2963907576 creator A5052311876 @default.
• W2963907576 creator A5057706417 @default.
• W2963907576 creator A5068632109 @default.
• W2963907576 creator A5087650145 @default.
• W2963907576 date "2019-01-31" @default.
• W2963907576 modified "2023-10-12" @default.
• W2963907576 title "Effect of High-Intensity Exercise on Multiple Sclerosis Function and Phosphorous Magnetic Resonance Spectroscopy Outcomes" @default.
• W2963907576 cites W1871573964 @default.
• W2963907576 cites W1974704788 @default.
• W2963907576 cites W1995188451 @default.
• W2963907576 cites W2020767502 @default.
• W2963907576 cites W2045024711 @default.
• W2963907576 cites W2049197285 @default.
• W2963907576 cites W2060934370 @default.
• W2963907576 cites W2061268385 @default.
• W2963907576 cites W2061693020 @default.
• W2963907576 cites W2068967233 @default.
• W2963907576 cites W2076960677 @default.
• W2963907576 cites W2084576650 @default.
• W2963907576 cites W2102570265 @default.
• W2963907576 cites W2108230902 @default.
• W2963907576 cites W2114753322 @default.
• W2963907576 cites W2122545833 @default.
• W2963907576 cites W2129030266 @default.
• W2963907576 cites W2136606872 @default.
• W2963907576 cites W2142577589 @default.
• W2963907576 cites W2159202946 @default.
• W2963907576 cites W2161952635 @default.
• W2963907576 cites W2169408223 @default.
• W2963907576 cites W2185623954 @default.
• W2963907576 cites W2278705906 @default.
• W2963907576 cites W2316826747 @default.
• W2963907576 cites W2494770722 @default.
• W2963907576 cites W2504417121 @default.
• W2963907576 cites W2538829438 @default.
• W2963907576 cites W2572375755 @default.
• W2963907576 cites W2588292672 @default.
• W2963907576 cites W2588355618 @default.
• W2963907576 cites W2589232523 @default.
• W2963907576 cites W2610242211 @default.
• W2963907576 cites W2750436552 @default.
• W2963907576 cites W2792537497 @default.
• W2963907576 cites W2793601497 @default.
• W2963907576 cites W2802134059 @default.
• W2963907576 cites W2862834803 @default.
• W2963907576 cites W2889827569 @default.
• W2963907576 doi "https://doi.org/10.1249/mss.0000000000001914" @default.
• W2963907576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6594188" @default.
• W2963907576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31205251" @default.
• W2963907576 hasPublicationYear "2019" @default.
• W2963907576 type Work @default.
• W2963907576 sameAs 2963907576 @default.
• W2963907576 citedByCount "22" @default.
• W2963907576 countsByYear W29639075762019 @default.
• W2963907576 countsByYear W29639075762020 @default.
• W2963907576 countsByYear W29639075762021 @default.
• W2963907576 countsByYear W29639075762022 @default.
• W2963907576 countsByYear W29639075762023 @default.
• W2963907576 crossrefType "journal-article" @default.
• W2963907576 hasAuthorship W2963907576A5000311910 @default.
• W2963907576 hasAuthorship W2963907576A5016561324 @default.
• W2963907576 hasAuthorship W2963907576A5035943065 @default.
• W2963907576 hasAuthorship W2963907576A5052311876 @default.
• W2963907576 hasAuthorship W2963907576A5057706417 @default.
• W2963907576 hasAuthorship W2963907576A5068632109 @default.
• W2963907576 hasAuthorship W2963907576A5087650145 @default.
• W2963907576 hasBestOaLocation W29639075762 @default.
• W2963907576 hasConcept C103038586 @default.
• W2963907576 hasConcept C117437137 @default.
• W2963907576 hasConcept C118552586 @default.
• W2963907576 hasConcept C126322002 @default.
• W2963907576 hasConcept C164705383 @default.
• W2963907576 hasConcept C1862650 @default.
• W2963907576 hasConcept C2778626300 @default.
• W2963907576 hasConcept C2780640218 @default.
• W2963907576 hasConcept C2780892749 @default.
• W2963907576 hasConcept C2908647359 @default.
• W2963907576 hasConcept C2986317502 @default.
• W2963907576 hasConcept C35785553 @default.
• W2963907576 hasConcept C71924100 @default.
• W2963907576 hasConcept C72563966 @default.
• W2963907576 hasConcept C99454951 @default.
• W2963907576 hasConceptScore W2963907576C103038586 @default.
• W2963907576 hasConceptScore W2963907576C117437137 @default.
• W2963907576 hasConceptScore W2963907576C118552586 @default.
• W2963907576 hasConceptScore W2963907576C126322002 @default.
• W2963907576 hasConceptScore W2963907576C164705383 @default.
• W2963907576 hasConceptScore W2963907576C1862650 @default.
• W2963907576 hasConceptScore W2963907576C2778626300 @default.
• W2963907576 hasConceptScore W2963907576C2780640218 @default.
• W2963907576 hasConceptScore W2963907576C2780892749 @default.
• W2963907576 hasConceptScore W2963907576C2908647359 @default.
• W2963907576 hasConceptScore W2963907576C2986317502 @default.

• next