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• W2963981566 abstract "Abstract Inflammatory bowel diseases (IBD) involve genetic and environmental factors that play major roles in disease pathogenesis. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 ( PTPN2 ) gene increase the risk of IBD and are associated with altered microbiome population dynamics in IBD. Moreover, expansion of intestinal pathobionts, such as adherent-invasive E. coli (AIEC), is strongly implicated in the pathogenesis of IBD as AIEC increases pro-inflammatory cytokine production and alters tight junction protein regulation suggesting a potential mechanism of pathogen-induced barrier dysfunction and inflammation. The aim of this study was to identify if PTPN2 deficiency disturbs the composition of the intestinal microbiome to promote expansion of specific bacteria with pathogenic properties. In mice constitutively lacking Ptpn2 we identified increased abundance of a novel adherent-invasive E. coli (AIEC) that showed similar adherence and invasion of intestinal epithelial cells, but greater survival in macrophages to the IBD associated AIEC, LF82. Furthermore, we confirmed this novel mouse AIEC ( m AIEC) caused disease when administered to germ-free and mice lacking segmented-filamentous bacteria (SFB). Moreover, m AIEC infection increased severity of and prevented recovery from dextran-sodium sulfate (DSS)-induced colitis. m AIEC genome sequence analysis showed >90% similarity to LF82. Interestingly, m AIEC contained distinct attachment genes not found in LF82 thereby also demonstrating the novelty of this AIEC. We show here for the first time that an IBD susceptibility gene, PTPN2 , plays a key role in modulating the gut microbiome to protect against a novel pathobiont. This study generates new insights into gene-environment-microbiome interactions in IBD." @default.
• W2963981566 created "2019-07-30" @default.
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• W2963981566 date "2019-07-22" @default.
• W2963981566 modified "2023-09-24" @default.
• W2963981566 title "The Autoimmune Susceptibility Gene, PTPN2, Restricts Expansion of a Novel Mouse Adherent-Invasive E. coli" @default.
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• W2963981566 doi "https://doi.org/10.1101/709634" @default.
• W2963981566 hasPublicationYear "2019" @default.
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