FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2963990500> ?p ?o ?g. }

• W2963990500 abstract "The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFSfree) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles, respectively. Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFSfree, or a combination of DFSfree+DFS:IR loaded matrix films were prepared by melt-cast technology. DFS content was 20% w/w in these matrix films. In vitro transcorneal permeability from the film formulations were compared against DFS solution, using a side-by-side diffusion apparatus, over a 6 h period. Ocular disposition of DFS from the solution, films and corresponding suspensions were evaluated in conscious New Zealand albino rabbits, 4 h and 8 h post-topical administration. All in vivo studies were carried out as per the University of Mississippi IACUC approved protocol. Complexation efficiency of DFS:IR was found to be 99% with a 1:1 ratio of DFS:IR. DFS release from DFS:IR suspension and the film were best-fit to a Higuchi model. In vitro transcorneal flux with the DFSfree+DFS:IR(1:1)(1 + 1) was twice that of only DFS:IR(1:1) film. In vivo, DFS solution and DFS:IR(1:1) suspension formulations were not able to maintain therapeutic DFS levels in the aqueous humor (AH). Both DFSfree and DFSfree+DFS:IR(1:1)(3 + 1) loaded matrix films were able to achieve and maintain high DFS concentrations in the AH, but elimination of DFS from the ocular tissues was much faster with the DFSfree formulation. DFSfree+DFS:IR combination loaded matrix films were able to deliver and maintain therapeutic DFS concentrations in the anterior ocular chamber for up to 8 h. Thus, free drug/IR complex loaded matrix films could be a potential topical ocular delivery platform for achieving immediate and sustained release characteristics." @default.
• W2963990500 created "2019-07-30" @default.
• W2963990500 creator A5021982705 @default.
• W2963990500 creator A5031137253 @default.
• W2963990500 creator A5048306553 @default.
• W2963990500 creator A5078051329 @default.
• W2963990500 creator A5078861399 @default.
• W2963990500 date "2017-07-10" @default.
• W2963990500 modified "2023-09-27" @default.
• W2963990500 title "Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery" @default.
• W2963990500 cites W1843302206 @default.
• W2963990500 cites W1964065696 @default.
• W2963990500 cites W1975450535 @default.
• W2963990500 cites W1985933245 @default.
• W2963990500 cites W1992533018 @default.
• W2963990500 cites W1992812840 @default.
• W2963990500 cites W1999169692 @default.
• W2963990500 cites W2005341497 @default.
• W2963990500 cites W2012615665 @default.
• W2963990500 cites W2016711754 @default.
• W2963990500 cites W2017754775 @default.
• W2963990500 cites W2018516156 @default.
• W2963990500 cites W2027085520 @default.
• W2963990500 cites W2028032162 @default.
• W2963990500 cites W2046711717 @default.
• W2963990500 cites W2060732617 @default.
• W2963990500 cites W2081513627 @default.
• W2963990500 cites W2086872077 @default.
• W2963990500 cites W2097158361 @default.
• W2963990500 cites W2115305419 @default.
• W2963990500 cites W2126645330 @default.
• W2963990500 cites W2131829357 @default.
• W2963990500 cites W2149625302 @default.
• W2963990500 cites W2325022985 @default.
• W2963990500 cites W2408180244 @default.
• W2963990500 cites W2483515633 @default.
• W2963990500 cites W1122793314 @default.
• W2963990500 hasPublicationYear "2017" @default.
• W2963990500 type Work @default.
• W2963990500 sameAs 2963990500 @default.
• W2963990500 citedByCount "0" @default.
• W2963990500 crossrefType "posted-content" @default.
• W2963990500 hasAuthorship W2963990500A5021982705 @default.
• W2963990500 hasAuthorship W2963990500A5031137253 @default.
• W2963990500 hasAuthorship W2963990500A5048306553 @default.
• W2963990500 hasAuthorship W2963990500A5078051329 @default.
• W2963990500 hasAuthorship W2963990500A5078861399 @default.
• W2963990500 hasConcept C106487976 @default.
• W2963990500 hasConcept C113196181 @default.
• W2963990500 hasConcept C13965031 @default.
• W2963990500 hasConcept C150903083 @default.
• W2963990500 hasConcept C152043487 @default.
• W2963990500 hasConcept C178790620 @default.
• W2963990500 hasConcept C184651966 @default.
• W2963990500 hasConcept C185592680 @default.
• W2963990500 hasConcept C207001950 @default.
• W2963990500 hasConcept C38652104 @default.
• W2963990500 hasConcept C41008148 @default.
• W2963990500 hasConcept C43617362 @default.
• W2963990500 hasConcept C86803240 @default.
• W2963990500 hasConceptScore W2963990500C106487976 @default.
• W2963990500 hasConceptScore W2963990500C113196181 @default.
• W2963990500 hasConceptScore W2963990500C13965031 @default.
• W2963990500 hasConceptScore W2963990500C150903083 @default.
• W2963990500 hasConceptScore W2963990500C152043487 @default.
• W2963990500 hasConceptScore W2963990500C178790620 @default.
• W2963990500 hasConceptScore W2963990500C184651966 @default.
• W2963990500 hasConceptScore W2963990500C185592680 @default.
• W2963990500 hasConceptScore W2963990500C207001950 @default.
• W2963990500 hasConceptScore W2963990500C38652104 @default.
• W2963990500 hasConceptScore W2963990500C41008148 @default.
• W2963990500 hasConceptScore W2963990500C43617362 @default.
• W2963990500 hasConceptScore W2963990500C86803240 @default.
• W2963990500 hasLocation W29639905001 @default.
• W2963990500 hasOpenAccess W2963990500 @default.
• W2963990500 hasPrimaryLocation W29639905001 @default.
• W2963990500 hasRelatedWork W2587504896 @default.
• W2963990500 isParatext "false" @default.
• W2963990500 isRetracted "false" @default.
• W2963990500 magId "2963990500" @default.
• W2963990500 workType "article" @default.