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• W2964010131 endingPage "1454" @default.
• W2964010131 startingPage "1436" @default.
• W2964010131 abstract "Many computational approaches estimate the effect of coding variants, but their predictions often disagree with each other. These contradictions confound users and raise questions regarding reliability. Performance assessments can indicate the expected accuracy for each method and highlight advantages and limitations. The Critical Assessment of Genome Interpretation (CAGI) community aims to organize objective and systematic assessments: They challenge predictors on unpublished experimental and clinical data and assign independent assessors to evaluate the submissions. We participated in CAGI experiments as predictors, using the Evolutionary Action (EA) method to estimate the fitness effect of coding mutations. EA is untrained, uses homology information, and relies on a formal equation: The fitness effect equals the functional sensitivity to residue changes multiplied by the magnitude of the substitution. In previous CAGI experiments (between 2011 and 2016), our submissions aimed to predict the protein activity of single mutants. In 2018 (CAGI5), we also submitted predictions regarding clinical associations, folding stability, and matching genomic data with phenotype. For all these diverse challenges, we used EA to predict the fitness effect of variants, adjusted to specifically address each question. Our submissions had consistently good performance, suggesting that EA predicts reliably the effects of genetic variants." @default.
• W2964010131 created "2019-07-30" @default.
• W2964010131 creator A5023680746 @default.
• W2964010131 creator A5024033300 @default.
• W2964010131 date "2019-09-01" @default.
• W2964010131 modified "2023-10-18" @default.
• W2964010131 title "CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation" @default.
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• W2964010131 doi "https://doi.org/10.1002/humu.23873" @default.
• W2964010131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6900054" @default.
• W2964010131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31317604" @default.

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