FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964131505> ?p ?o ?g. }

• W2964131505 endingPage "S5" @default.
• W2964131505 startingPage "S4" @default.
• W2964131505 abstract "BACKGROUND: Inflammatory bowel diseases (IBD) cause a wide variety of gastrointestinal symptoms including abdominal pain, diarrhea, and rectal bleeding. It is well known that the type and level of symptoms that patients experience varies widely. In previously presented work, our group performed a series of focus groups to understand the impact of different symptoms on patients. We identified that symptoms that cause disability, anxiety, and those that are out of the patient's control are perceived to be the most burdensome. The 4 gastrointestinal symptoms that patients described as most burdensome were abdominal pain, rectal bleeding, urgency and incontinence, and stool frequency. Additionally, we observed that the relative burden of different symptoms varied. Therefore, the aim of the current study is to quantify the relative importance of 4 common IBD symptoms and their severity for IBD patients. METHODS: To quantify the relative importance of different symptoms and severity levels, a choice-based conjoint (CBC) analysis survey was developed. In the survey, patients are asked to complete 16 CBC questions, in which they choose one out of 2 scenarios with different levels of severity for 4 different symptoms. Abdominal pain, rectal bleeding, stool frequency, and urgency/incontinence are the 4 symptoms included in the survey. Severity levels are based on the levels used in common disease activity measures. Clinical information including the type of IBD and disease duration is obtained from the chart. A Hierarchical Bayes analysis is used to quantify the relative importance of different severity levels for each of the symptoms. Patients 18 years or older with a confirmed IBD diagnosis are eligible to participate. Patients with a stoma are excluded. RESULTS: Thus far, 100 eligible patients have completed the survey (46% male, mean age 39 [SD 15]). Two patients were excluded after finalizing the survey as they did not fulfill eligibility criteria (stoma and unconfirmed IBD diagnosis). Four eligible patients started but did not finish the survey. Of the included patients, 55% were diagnosed with CD, 39% with UC, and 6% with IBDU, with an average disease duration of 9 years (SD 7). Conjoint analysis revealed that urgency/incontinence was the most important symptom for patients: 1.5× more important than abdominal pain, 2.2× more important than rectal bleeding, and 3.5× more important than stool frequency. As expected, higher symptom levels were perceived to be more important than lower symptom levels. In particular, urgency leading to incontinence was a major factor driving patients decisions to select one scenario over another. CONCLUSION(S): In this study, we quantified the relative importance of 4 common symptoms and severity levels that IBD patients experience. We found large differences in the observed importance of different symptoms for IBD patients. Urgency/incontinence was shown to be particularly bothersome, while stool frequency by itself was not perceived to be very burdensome. These results will be used to develop a score to quantify symptom-burden in IBD patients." @default.
• W2964131505 created "2019-07-30" @default.
• W2964131505 creator A5003467353 @default.
• W2964131505 creator A5009160605 @default.
• W2964131505 creator A5020625448 @default.
• W2964131505 creator A5025107689 @default.
• W2964131505 creator A5035661360 @default.
• W2964131505 creator A5036610765 @default.
• W2964131505 date "2019-07-01" @default.
• W2964131505 modified "2023-09-26" @default.
• W2964131505 title "P015 Quantification of inflammatory bowel disease symptom burden based on patient preferences" @default.
• W2964131505 doi "https://doi.org/10.14309/01.ajg.0000578132.90149.75" @default.
• W2964131505 hasPublicationYear "2019" @default.
• W2964131505 type Work @default.
• W2964131505 sameAs 2964131505 @default.
• W2964131505 citedByCount "0" @default.
• W2964131505 crossrefType "journal-article" @default.
• W2964131505 hasAuthorship W2964131505A5003467353 @default.
• W2964131505 hasAuthorship W2964131505A5009160605 @default.
• W2964131505 hasAuthorship W2964131505A5020625448 @default.
• W2964131505 hasAuthorship W2964131505A5025107689 @default.
• W2964131505 hasAuthorship W2964131505A5035661360 @default.
• W2964131505 hasAuthorship W2964131505A5036610765 @default.
• W2964131505 hasBestOaLocation W29641315051 @default.
• W2964131505 hasConcept C118552586 @default.
• W2964131505 hasConcept C126322002 @default.
• W2964131505 hasConcept C1862650 @default.
• W2964131505 hasConcept C2778260677 @default.
• W2964131505 hasConcept C2778271842 @default.
• W2964131505 hasConcept C2779134260 @default.
• W2964131505 hasConcept C2779802037 @default.
• W2964131505 hasConcept C2780955771 @default.
• W2964131505 hasConcept C30036603 @default.
• W2964131505 hasConcept C558461103 @default.
• W2964131505 hasConcept C71924100 @default.
• W2964131505 hasConceptScore W2964131505C118552586 @default.
• W2964131505 hasConceptScore W2964131505C126322002 @default.
• W2964131505 hasConceptScore W2964131505C1862650 @default.
• W2964131505 hasConceptScore W2964131505C2778260677 @default.
• W2964131505 hasConceptScore W2964131505C2778271842 @default.
• W2964131505 hasConceptScore W2964131505C2779134260 @default.
• W2964131505 hasConceptScore W2964131505C2779802037 @default.
• W2964131505 hasConceptScore W2964131505C2780955771 @default.
• W2964131505 hasConceptScore W2964131505C30036603 @default.
• W2964131505 hasConceptScore W2964131505C558461103 @default.
• W2964131505 hasConceptScore W2964131505C71924100 @default.
• W2964131505 hasIssue "1" @default.
• W2964131505 hasLocation W29641315051 @default.
• W2964131505 hasLocation W29641315052 @default.
• W2964131505 hasOpenAccess W2964131505 @default.
• W2964131505 hasPrimaryLocation W29641315051 @default.
• W2964131505 hasRelatedWork W1987723975 @default.
• W2964131505 hasRelatedWork W2027370521 @default.
• W2964131505 hasRelatedWork W2315014465 @default.
• W2964131505 hasRelatedWork W2348692972 @default.
• W2964131505 hasRelatedWork W2350043805 @default.
• W2964131505 hasRelatedWork W2355871716 @default.
• W2964131505 hasRelatedWork W2359003803 @default.
• W2964131505 hasRelatedWork W2556419787 @default.
• W2964131505 hasRelatedWork W3032741126 @default.
• W2964131505 hasRelatedWork W4282966418 @default.
• W2964131505 hasVolume "114" @default.
• W2964131505 isParatext "false" @default.
• W2964131505 isRetracted "false" @default.
• W2964131505 magId "2964131505" @default.
• W2964131505 workType "article" @default.