FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964138618> ?p ?o ?g. }

• W2964138618 abstract "Abstract Background Although malaria transmission was eradicated from southeast Brazil, a significant increase in the number of Plasmodium vivax-like autochthonous human cases has been reported in remote areas of the Atlantic Forest in the last decades in Rio de Janeiro (RJ) state, including an outbreak in 2015-2016. The singular clinical and epidemiological aspects of several human cases combined with molecular and genetic data revealed that they were due to the non-human primate (NHP) parasite P. simium. The full understanding of the epidemiology of the autochthonous malaria in southeastern Brazil depends, however, upon the knowledge on the circulation of NHP Plasmodium in the foci and the determination of its reservoirs. Methodology A large sampling effort was carried out in the Atlantic forest of RJ and its bordering states (Minas Gerais, São Paulo, Espírito Santo) for capture and examination of free-living NHPs. Blood and/or viscera were analyzed for Plasmodia infections through molecular and microscopic techniques. Principal findings In total, 146 NHPs of six species, from 30 counties in four states were tested. Howler monkeys ( A. guariba clamitans) were the only NHP species found infected. In RJ, 26% of howlers were positive, among them 17% were found to be infected with P. simium . Importantly, specific single nucleotide polymorphisms were detected in all P. simium infected howlers regardless geographical origin of malaria foci. Interestingly, 71% of P. simium infected NHP were from the coastal slope of a mountain chain (Serra do Mar), where most human cases have been occurring. P. brasilianum/malariae was detected for the first time in 14% free-living howlers in RJ as well as in 25% of those from the Espírito Santo state. Moreover, malarial pigment was detected in spleen fragments of 50% of a subsample composed of howler monkeys found dead in both RJ and ES. All NHPs were negative for P. falciparum . Conclusions/Significance Our data indicate the howler monkeys as the main reservoir of the Atlantic forest human malaria in RJ and other sites in Southeast Brazil and reinforce its zoonotic nature. Author summary The present work consists of an unprecedented capture effort and large-scale field survey of plasmodial species in Non-human primates (NHPs) in RJ, a state recording a three-decade history of autochthonous human cases of benign tertian malaria pending epidemiological clarification of their origin. For the first time, we describe infection rates by Plasmodium sp. in free-living NHP, match the spatial distribution of P. simium in NHP with that of local human cases of benign tertian malaria due to this parasite, disclose howler monkeys as the only confirmed reservoir of this zoonotic malaria in the state and showed that specific single nucleotide polymorphisms were present in all P. simium infected howlers, regardless of the geographical origin of malaria foci. It is also the first time that P. brasilianum/malariae is recorded in free-living NHPs from Rio de Janeiro and the widespread distribution of this quartan-malaria parasite of zoonotic potential in the state is illustrated. Together, these findings increase the understanding about the simian malaria parasites in Atlantic Forests, as well as on the zoonotic character of autochthonous human malaria in Rio de Janeiro, providing subsidies for shaping surveillance and control." @default.
• W2964138618 created "2019-07-30" @default.
• W2964138618 creator A5001372073 @default.
• W2964138618 creator A5003203847 @default.
• W2964138618 creator A5003330025 @default.
• W2964138618 creator A5006984938 @default.
• W2964138618 creator A5014189492 @default.
• W2964138618 creator A5016825077 @default.
• W2964138618 creator A5017358864 @default.
• W2964138618 creator A5024356250 @default.
• W2964138618 creator A5027268587 @default.
• W2964138618 creator A5030494344 @default.
• W2964138618 creator A5031725400 @default.
• W2964138618 creator A5032743484 @default.
• W2964138618 creator A5042083385 @default.
• W2964138618 creator A5053517058 @default.
• W2964138618 creator A5053595443 @default.
• W2964138618 creator A5066338821 @default.
• W2964138618 creator A5087259355 @default.
• W2964138618 creator A5089634660 @default.
• W2964138618 date "2019-07-26" @default.
• W2964138618 modified "2023-10-01" @default.
• W2964138618 title "Howler monkeys are the reservoir of malaria parasites causing zoonotic infections in the Atlantic forest of Rio de Janeiro" @default.
• W2964138618 cites W1828175302 @default.
• W2964138618 cites W1829143258 @default.
• W2964138618 cites W1879981610 @default.
• W2964138618 cites W1965965664 @default.
• W2964138618 cites W1977784023 @default.
• W2964138618 cites W1989142450 @default.
• W2964138618 cites W1997986338 @default.
• W2964138618 cites W2001808105 @default.
• W2964138618 cites W2017152819 @default.
• W2964138618 cites W2018269465 @default.
• W2964138618 cites W2033640723 @default.
• W2964138618 cites W2035163466 @default.
• W2964138618 cites W2040567919 @default.
• W2964138618 cites W2042418077 @default.
• W2964138618 cites W2044907227 @default.
• W2964138618 cites W2052990910 @default.
• W2964138618 cites W2076636645 @default.
• W2964138618 cites W2093368243 @default.
• W2964138618 cites W2104462056 @default.
• W2964138618 cites W2105294534 @default.
• W2964138618 cites W2123321526 @default.
• W2964138618 cites W2124893164 @default.
• W2964138618 cites W2141879954 @default.
• W2964138618 cites W2144980344 @default.
• W2964138618 cites W2151128413 @default.
• W2964138618 cites W2158091936 @default.
• W2964138618 cites W2161264789 @default.
• W2964138618 cites W2168981556 @default.
• W2964138618 cites W2317198665 @default.
• W2964138618 cites W2325284571 @default.
• W2964138618 cites W2404578185 @default.
• W2964138618 cites W2413716212 @default.
• W2964138618 cites W2492704920 @default.
• W2964138618 cites W2528500969 @default.
• W2964138618 cites W2587505853 @default.
• W2964138618 cites W2607492224 @default.
• W2964138618 cites W2622731166 @default.
• W2964138618 cites W2753380285 @default.
• W2964138618 cites W2782103060 @default.
• W2964138618 cites W2782971137 @default.
• W2964138618 cites W2883450420 @default.
• W2964138618 cites W2891978600 @default.
• W2964138618 cites W2934202356 @default.
• W2964138618 cites W2952056274 @default.
• W2964138618 cites W2952172563 @default.
• W2964138618 cites W319121618 @default.
• W2964138618 cites W38920783 @default.
• W2964138618 doi "https://doi.org/10.1101/715623" @default.
• W2964138618 hasPublicationYear "2019" @default.
• W2964138618 type Work @default.
• W2964138618 sameAs 2964138618 @default.
• W2964138618 citedByCount "0" @default.
• W2964138618 crossrefType "posted-content" @default.
• W2964138618 hasAuthorship W2964138618A5001372073 @default.
• W2964138618 hasAuthorship W2964138618A5003203847 @default.
• W2964138618 hasAuthorship W2964138618A5003330025 @default.
• W2964138618 hasAuthorship W2964138618A5006984938 @default.
• W2964138618 hasAuthorship W2964138618A5014189492 @default.
• W2964138618 hasAuthorship W2964138618A5016825077 @default.
• W2964138618 hasAuthorship W2964138618A5017358864 @default.
• W2964138618 hasAuthorship W2964138618A5024356250 @default.
• W2964138618 hasAuthorship W2964138618A5027268587 @default.
• W2964138618 hasAuthorship W2964138618A5030494344 @default.
• W2964138618 hasAuthorship W2964138618A5031725400 @default.
• W2964138618 hasAuthorship W2964138618A5032743484 @default.
• W2964138618 hasAuthorship W2964138618A5042083385 @default.
• W2964138618 hasAuthorship W2964138618A5053517058 @default.
• W2964138618 hasAuthorship W2964138618A5053595443 @default.
• W2964138618 hasAuthorship W2964138618A5066338821 @default.
• W2964138618 hasAuthorship W2964138618A5087259355 @default.
• W2964138618 hasAuthorship W2964138618A5089634660 @default.
• W2964138618 hasBestOaLocation W29641386181 @default.
• W2964138618 hasConcept C116675565 @default.
• W2964138618 hasConcept C119599485 @default.
• W2964138618 hasConcept C127413603 @default.
• W2964138618 hasConcept C136764020 @default.
• W2964138618 hasConcept C159047783 @default.

• next