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• W2964156782 abstract "In an adapted population of mutators in which most mutations are deleterious, a nonmutator that lowers the mutation rate is under indirect selection and can sweep to fixation. Using a multitype branching process, we calculate the fixation probability of a rare nonmutator in a large population of asexual mutators. We show that when beneficial mutations are absent, the fixation probability is a nonmonotonic function of the mutation rate of the mutator: it first increases sublinearly and then decreases exponentially. We also find that beneficial mutations can enhance the fixation probability of a nonmutator. Our analysis is relevant to an understanding of recent experiments in which a reduction in the mutation rates has been observed." @default.
• W2964156782 created "2019-07-30" @default.
• W2964156782 creator A5033110282 @default.
• W2964156782 creator A5036482063 @default.
• W2964156782 date "2017-11-01" @default.
• W2964156782 modified "2023-09-28" @default.
• W2964156782 title "Fixation probability of a nonmutator in a large population of asexual mutators" @default.
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• W2964156782 doi "https://doi.org/10.1016/j.jtbi.2017.08.027" @default.
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