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• W2964191119 endingPage "102053" @default.
• W2964191119 startingPage "102053" @default.
• W2964191119 abstract "Here, we report various therapeutic cargo-loadable DNA nanostructures that are shelled in polydopamine and noncovalently tethered with cancer cell-targeting DNA aptamers. Initial DNA nanostructure was formed by rolling-circle amplification and condensation with Mu peptides. This DNA nanostructure was loaded with an antisense oligonucleotide, a photosensitizer, or an anticancer chemotherapeutic drug. Each therapeutic agent-loaded DNA nanostructure was then shelled with polydopamine (PDA), and noncovalently decorated with a poly adenine-tailed nucleic acid aptamer (PA) specific for PTK7 receptor, resulting in PA-tethered and PDA-shelled DNA nanostructure (PA/PDN). PDA coating shell enabled photothermal therapy. In the cells overexpressing PTK7 receptor, photosensitizer-loaded PA/PDN showed greater photodynamic activity. Doxorubicin-loaded PA/PDN exerted higher anticancer activity than the other groups. Antisense oligonucleotide-loaded PA/PDN provided selective reduction of target proteins compared with other groups. Our results suggest that the PA-tethered and PDA-shelled DNA nanostructures could enable the specific receptor-targeted phototherapy, chemotherapy, and gene therapy against cancer cells." @default.
• W2964191119 created "2019-07-30" @default.
• W2964191119 creator A5014332786 @default.
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• W2964191119 date "2020-02-01" @default.
• W2964191119 modified "2023-10-17" @default.
• W2964191119 title "Noncovalent tethering of nucleic acid aptamer on DNA nanostructure for targeted photo/chemo/gene therapies" @default.
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• W2964191119 doi "https://doi.org/10.1016/j.nano.2019.102053" @default.
• W2964191119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31344502" @default.
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