Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964223839> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2964223839 abstract "The detection of drug metabolites, particularly for minor metabolites, continues to be a challenge owing to the complexity of biological samples. Imperatorin is an active natural furocoumarin ingredient originating from many traditional Chinese herbal medicines. In the present study, the metabolites of imperatorin after oral administration were qualitatively investigated, and possible metabolic pathways of it were subsequently proposed. Bile samples were collected after oral administration and pretreated by the application of Waters Ostro. The QTOF-MS/MS data was acquired using ultra high performance liquid chromatography coupled to quadrupole time flight spectrometry (UPLC-QTOF-MS). Based on this analytical strategy, 32 metabolites (23 phase I and 9 phase II metabolites) were identified in rat bile. The results demonstrated that C5H8 could be easily eliminated from imperatorin forming the metabolite M1. It also indicated that imperatorin and M1 underwent extensive metabolic reactions including oxidation, hydrolysis, methylation, glucuronide conjugation, C2H5NO2S conjugation and C3H5NO2S conjugation. This is the first study of imperatorin metabolism in bile samples. The proposed metabolic pathways in this research will provide essential data for further pharmaceutical studies of other linear-type furocoumarins." @default.
- W2964223839 created "2019-07-30" @default.
- W2964223839 creator A5014162279 @default.
- W2964223839 creator A5026986071 @default.
- W2964223839 creator A5047352844 @default.
- W2964223839 creator A5052763987 @default.
- W2964223839 creator A5080096406 @default.
- W2964223839 date "2016-01-01" @default.
- W2964223839 modified "2023-09-28" @default.
- W2964223839 title "UPLC-QTOF-MS/MS based screening and identification of the metabolites in rat bile after oral administration of imperatorin B Analytical technologies in the biomedical and life sciences" @default.
- W2964223839 hasPublicationYear "2016" @default.
- W2964223839 type Work @default.
- W2964223839 sameAs 2964223839 @default.
- W2964223839 citedByCount "0" @default.
- W2964223839 crossrefType "journal-article" @default.
- W2964223839 hasAuthorship W2964223839A5014162279 @default.
- W2964223839 hasAuthorship W2964223839A5026986071 @default.
- W2964223839 hasAuthorship W2964223839A5047352844 @default.
- W2964223839 hasAuthorship W2964223839A5052763987 @default.
- W2964223839 hasAuthorship W2964223839A5080096406 @default.
- W2964223839 hasConcept C179998833 @default.
- W2964223839 hasConcept C185592680 @default.
- W2964223839 hasConcept C2777477808 @default.
- W2964223839 hasConcept C2778692553 @default.
- W2964223839 hasConcept C2779186261 @default.
- W2964223839 hasConcept C2908991464 @default.
- W2964223839 hasConcept C2909743731 @default.
- W2964223839 hasConcept C43617362 @default.
- W2964223839 hasConcept C552990157 @default.
- W2964223839 hasConcept C55493867 @default.
- W2964223839 hasConcept C71924100 @default.
- W2964223839 hasConcept C75473681 @default.
- W2964223839 hasConcept C98274493 @default.
- W2964223839 hasConceptScore W2964223839C179998833 @default.
- W2964223839 hasConceptScore W2964223839C185592680 @default.
- W2964223839 hasConceptScore W2964223839C2777477808 @default.
- W2964223839 hasConceptScore W2964223839C2778692553 @default.
- W2964223839 hasConceptScore W2964223839C2779186261 @default.
- W2964223839 hasConceptScore W2964223839C2908991464 @default.
- W2964223839 hasConceptScore W2964223839C2909743731 @default.
- W2964223839 hasConceptScore W2964223839C43617362 @default.
- W2964223839 hasConceptScore W2964223839C552990157 @default.
- W2964223839 hasConceptScore W2964223839C55493867 @default.
- W2964223839 hasConceptScore W2964223839C71924100 @default.
- W2964223839 hasConceptScore W2964223839C75473681 @default.
- W2964223839 hasConceptScore W2964223839C98274493 @default.
- W2964223839 hasLocation W29642238391 @default.
- W2964223839 hasOpenAccess W2964223839 @default.
- W2964223839 hasPrimaryLocation W29642238391 @default.
- W2964223839 hasRelatedWork W1667566583 @default.
- W2964223839 hasRelatedWork W1902813413 @default.
- W2964223839 hasRelatedWork W2054264920 @default.
- W2964223839 hasRelatedWork W2131578499 @default.
- W2964223839 hasRelatedWork W2332372462 @default.
- W2964223839 hasRelatedWork W2511330338 @default.
- W2964223839 hasRelatedWork W2514893234 @default.
- W2964223839 hasRelatedWork W2520038302 @default.
- W2964223839 hasRelatedWork W2529646692 @default.
- W2964223839 hasRelatedWork W2560199866 @default.
- W2964223839 hasRelatedWork W2592272898 @default.
- W2964223839 hasRelatedWork W2592433324 @default.
- W2964223839 hasRelatedWork W2619677362 @default.
- W2964223839 hasRelatedWork W2807337386 @default.
- W2964223839 hasRelatedWork W2901070389 @default.
- W2964223839 hasRelatedWork W2903403143 @default.
- W2964223839 hasRelatedWork W2942777588 @default.
- W2964223839 hasRelatedWork W2984546359 @default.
- W2964223839 hasRelatedWork W2999707110 @default.
- W2964223839 hasRelatedWork W3009449733 @default.
- W2964223839 isParatext "false" @default.
- W2964223839 isRetracted "false" @default.
- W2964223839 magId "2964223839" @default.
- W2964223839 workType "article" @default.