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• W2964226498 abstract "Clinical trials traditionally employ blinding as a design mechanism to reduce the influence of placebo effects. In practice, however, it can be difficult or impossible to blind study participants and unblinded trials are common in medical research. Here we show how instrumental variables can be used to quantify and disentangle treatment and placebo effects in randomized clinical trials comparing control and active treatments in the presence of confounders. The key idea is to use randomization to separately manipulate treatment assignment and psychological encouragement conversations/interactions that increase the participants' desire for improved symptoms. The proposed approach is able to improve the estimation of treatment effects in blinded studies and, most importantly, opens the doors to account for placebo effects in unblinded trials." @default.
• W2964226498 created "2019-07-30" @default.
• W2964226498 creator A5029959684 @default.
• W2964226498 date "2016-11-21" @default.
• W2964226498 modified "2023-09-27" @default.
• W2964226498 title "Using instrumental variables to disentangle treatment and placebo effects in blinded and unblinded randomized clinical trials influenced by unmeasured confounders" @default.
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• W2964226498 doi "https://doi.org/10.1038/srep37154" @default.
• W2964226498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5116680" @default.
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• W2964226498 hasPublicationYear "2016" @default.
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