FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964243148> ?p ?o ?g. }

• W2964243148 abstract "Diarrhea is among the main causes of pediatric mortality in the Philippines. Probiotics have been shown to be beneficial in the management of acute diarrhea. Accordingly, the aim of this population-based study was to assess the safety and effectiveness of Bacillus clausii as an adjunct to standard therapy in Filipino children with acute community-acquired diarrhea of viral origin or associated with antibiotic administration.A total of 3178 patients (median age of 2 years) were enrolled in this open-label, multicenter, observational study, and were treated with one to two vials of Bacillus clausii in the following bacterial stains: O/C, SIN, N/R, and T (oral suspension of 2 billion spores per 5-mL vial) for 5 to 7 days. Diarrhea duration, number of stools per day, improvement in gastrointestinal symptoms, children's overall acceptability of Bacillus clausii therapy, and safety and tolerability were assessed. Concomitant treatment with oral rehydration solutions (26.6%), zinc (23.9%), and antibiotics prescribed for conditions other than diarrhea (13.6%) was recorded during the study. All other probiotics and antidiarrheals were prohibited.Therapy with Bacillus clausii was well-tolerated, and the adverse event rate was very low (0.09%). All reported adverse events, which included vomiting, erythematous rashes and stool color change, were mild to moderate. In more than half of the per-protocol population (1535/2916; 52.6%), diarrhea was resolved within the first 3 days of treatment with Bacillus clausii. There was no significant difference (p = 0.297) in mean diarrhea duration between patients with either antibiotic-associated (3.3 ± 1.3 days) or viral diarrhea (3.4 ± 1.3 days). However, children who only received Bacillus clausii supplementation without zinc had a significantly shorter diarrhea duration (3.3 ± 1.3 days) compared to zinc-treated children (3.6 ± 1.6 days; p < 0.001). Bacillus clausii significantly reduced the mean number of stools per day, from 5.2 ± 2.0 stools at baseline to 1.2 ± 0.6 stools at study end (p < 0.001). Similarly, the proportion of patients with loose stools decreased from 81.6% at baseline to 9.2% at end of treatment period. Acceptability of Bacillus clausii therapy was high.This study adds knowledge on the good safety profile and on the effectiveness of Bacillus clausii as an adjunct treatment for acute childhood diarrhea." @default.
• W2964243148 created "2019-07-30" @default.
• W2964243148 creator A5013697926 @default.
• W2964243148 creator A5018499012 @default.
• W2964243148 creator A5074074810 @default.
• W2964243148 date "2019-07-23" @default.
• W2964243148 modified "2023-10-01" @default.
• W2964243148 title "Bacillus clausii as adjunctive treatment for acute community-acquired diarrhea among Filipino children: a large-scale, multicenter, open-label study (CODDLE)" @default.
• W2964243148 cites W1606692379 @default.
• W2964243148 cites W1919217794 @default.
• W2964243148 cites W1965578335 @default.
• W2964243148 cites W1966875539 @default.
• W2964243148 cites W1993569919 @default.
• W2964243148 cites W2001373241 @default.
• W2964243148 cites W2033307963 @default.
• W2964243148 cites W2052050128 @default.
• W2964243148 cites W2067785086 @default.
• W2964243148 cites W2068068844 @default.
• W2964243148 cites W2086973601 @default.
• W2964243148 cites W2103736238 @default.
• W2964243148 cites W2120773585 @default.
• W2964243148 cites W2127961362 @default.
• W2964243148 cites W2136589285 @default.
• W2964243148 cites W2154673405 @default.
• W2964243148 cites W2156116033 @default.
• W2964243148 cites W2335167031 @default.
• W2964243148 cites W2527824850 @default.
• W2964243148 cites W2573954513 @default.
• W2964243148 cites W2741572010 @default.
• W2964243148 cites W2886217529 @default.
• W2964243148 doi "https://doi.org/10.1186/s40794-019-0089-5" @default.
• W2964243148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6651909" @default.
• W2964243148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31367461" @default.
• W2964243148 hasPublicationYear "2019" @default.
• W2964243148 type Work @default.
• W2964243148 sameAs 2964243148 @default.
• W2964243148 citedByCount "26" @default.
• W2964243148 countsByYear W29642431482019 @default.
• W2964243148 countsByYear W29642431482020 @default.
• W2964243148 countsByYear W29642431482021 @default.
• W2964243148 countsByYear W29642431482022 @default.
• W2964243148 countsByYear W29642431482023 @default.
• W2964243148 crossrefType "journal-article" @default.
• W2964243148 hasAuthorship W2964243148A5013697926 @default.
• W2964243148 hasAuthorship W2964243148A5018499012 @default.
• W2964243148 hasAuthorship W2964243148A5074074810 @default.
• W2964243148 hasBestOaLocation W29642431481 @default.
• W2964243148 hasConcept C126322002 @default.
• W2964243148 hasConcept C197934379 @default.
• W2964243148 hasConcept C2778375690 @default.
• W2964243148 hasConcept C2779802037 @default.
• W2964243148 hasConcept C2780852908 @default.
• W2964243148 hasConcept C2908647359 @default.
• W2964243148 hasConcept C71924100 @default.
• W2964243148 hasConcept C99454951 @default.
• W2964243148 hasConceptScore W2964243148C126322002 @default.
• W2964243148 hasConceptScore W2964243148C197934379 @default.
• W2964243148 hasConceptScore W2964243148C2778375690 @default.
• W2964243148 hasConceptScore W2964243148C2779802037 @default.
• W2964243148 hasConceptScore W2964243148C2780852908 @default.
• W2964243148 hasConceptScore W2964243148C2908647359 @default.
• W2964243148 hasConceptScore W2964243148C71924100 @default.
• W2964243148 hasConceptScore W2964243148C99454951 @default.
• W2964243148 hasFunder F4320307781 @default.
• W2964243148 hasIssue "1" @default.
• W2964243148 hasLocation W29642431481 @default.
• W2964243148 hasLocation W29642431482 @default.
• W2964243148 hasLocation W29642431483 @default.
• W2964243148 hasLocation W29642431484 @default.
• W2964243148 hasOpenAccess W2964243148 @default.
• W2964243148 hasPrimaryLocation W29642431481 @default.
• W2964243148 hasRelatedWork W1201736814 @default.
• W2964243148 hasRelatedWork W2041128529 @default.
• W2964243148 hasRelatedWork W2087016115 @default.
• W2964243148 hasRelatedWork W2156337883 @default.
• W2964243148 hasRelatedWork W2360407479 @default.
• W2964243148 hasRelatedWork W2372442000 @default.
• W2964243148 hasRelatedWork W2394317912 @default.
• W2964243148 hasRelatedWork W2420543829 @default.
• W2964243148 hasRelatedWork W2894773683 @default.
• W2964243148 hasRelatedWork W2978537175 @default.
• W2964243148 hasVolume "5" @default.
• W2964243148 isParatext "false" @default.
• W2964243148 isRetracted "false" @default.
• W2964243148 magId "2964243148" @default.
• W2964243148 workType "article" @default.