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- W2964249516 abstract "Minimizing exposure of the fetus to medication and reducing adverse off-target effects in the mother are the primary challenges in developing novel drugs to treat pregnancy complications. Nanomedicine has introduced opportunities for the development of novel platforms enabling targeted delivery of drugs in pregnancy. This review sets out to discuss the advances and potential of surface-functionalized nanoparticles in the targeted therapy of pregnancy complications. We first describe the human placental anatomy, which is fundamental for developing placenta-targeted therapy, and then we review current knowledge of nanoparticle transplacental transport mechanisms. Meanwhile, recent surface-functionalized nanoparticles for targeting the uterus and placenta are examined. Indeed, surface-functionalized nanoparticles could help prevent transplacental passage and promote placental-specific drug delivery, thereby enhancing efficacy and improving safety. We have achieved promising results in targeting the placenta via placental chondroitin sulfate A (plCSA), which is exclusively expressed in the placenta, using plCSA binding peptide (plCSA-BP)-decorated nanoparticles. Others have also focused on using placenta- and uterus-enriched molecules as targets to deliver therapeutics via surface-functionalized nanoparticles. Additionally, we propose that placenta-specific exosomes and surface-modified exosomes might be potential tools in the targeted therapy of pregnancy complications. Altogether, surface-functionalized nanoparticles have great potential value as clinical tools in the targeted therapy of pregnancy complications." @default.
- W2964249516 created "2019-07-30" @default.
- W2964249516 creator A5019601112 @default.
- W2964249516 creator A5024656093 @default.
- W2964249516 creator A5029439536 @default.
- W2964249516 creator A5053263581 @default.
- W2964249516 creator A5053657539 @default.
- W2964249516 date "2019-07-25" @default.
- W2964249516 modified "2023-10-14" @default.
- W2964249516 title "Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications" @default.
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