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• W2964268777 abstract "Abstract Two new diorganotin(IV) complexes with the general formula (RC 7 H 6 ) 2 Sn(L) (where RC 7 H 6 = p -ClBn, C1 ; and p -FBn, C2 ) were prepared based on the reaction of 2,3- bis (4-hydroxysalicylidene-amino)-maleic nitrile ( L ) with substituted dibenzyltin(IV) dichloride. The structures were confirmed by elemental analysis, Fourier transform infrared (FT-IR), proton and carbon nuclear magnetic resonance ( 1 H and 13 C NMR). They were tested against several cancer cell lines by using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. C1 , which was most effective against MCF-7 breast cancer cell line, was further investigated in formulation and encapsulation studies, including drug encapsulation efficiency, particle size, morphology and in vitro drug release. An encapsulation of about 90% was achieved with particles of 128 nm average diameter. Field emission scanning electron microscopy (FESEM) confirmed a spherical shape for the encapsulated C1 . The cumulative drug release over a period of 60 days in phosphate buffered saline (PBS) at pH 7.4 was 75%. Based on these results, the formulated drug has the potential of a slow release drug for cancer chemotherapy." @default.
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• W2964268777 date "2019-07-16" @default.
• W2964268777 modified "2023-09-23" @default.
• W2964268777 title "Synthesis, structural characterization, cytotoxicity and encapsulation studies of N,Nʹ-(1, 2-dicyano-1,2-vinylene)-bis(4-hydroxysalicylideneaminato) di(p-chlorobenzyl)tin as potential anticancer drug" @default.
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• W2964268777 doi "https://doi.org/10.1515/mgmc-2019-0010" @default.
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