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• W2964273526 abstract "One of the most important problems in development is how epigenetic domains can first be established, and then maintained, within cells. To address this question, we propose a framework that couples three-dimensional chromatin folding dynamics to a “recoloring” process modeling the writing of epigenetic marks. Because many intrachromatin interactions are mediated by bridging proteins, we consider a “two-state” model with self-attractive interactions between two epigenetic marks that are alike (either active or inactive). This model displays a first-order-like transition between a swollen, epigenetically disordered phase and a compact, epigenetically coherent chromatin globule. If the self-attraction strength exceeds a threshold, the chromatin dynamics becomes glassy, and the corresponding interaction network freezes. By modifying the epigenetic read-write process according to more biologically inspired assumptions, our polymer model with recoloring recapitulates the ultrasensitive response of epigenetic switches to perturbations and accounts for long-lived multidomain conformations, strikingly similar to the topologically associating domains observed in eukaryotic chromosomes.Received 15 June 2016DOI:https://doi.org/10.1103/PhysRevX.6.041047Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.Published by the American Physical SocietyPhysics Subject Headings (PhySH)Research AreasEpigeneticsPolymer conformation & topologyPolymer foldingPhysical SystemsChromatinChromosomesTechniquesMolecular dynamicsBiological PhysicsStatistical PhysicsPolymers & Soft Matter" @default.
• W2964273526 created "2019-07-30" @default.
• W2964273526 creator A5001134453 @default.
• W2964273526 creator A5066158937 @default.
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• W2964273526 date "2016-12-09" @default.
• W2964273526 modified "2023-10-15" @default.
• W2964273526 title "Polymer model with Epigenetic Recoloring Reveals a Pathway for the <i>de novo</i> Establishment and 3D Organization of Chromatin Domains" @default.
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• W2964273526 doi "https://doi.org/10.1103/physrevx.6.041047" @default.
• W2964273526 hasPublicationYear "2016" @default.
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