FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964277555> ?p ?o ?g. }

• W2964277555 endingPage "1399" @default.
• W2964277555 startingPage "1381" @default.
• W2964277555 abstract "Abstract Two-locus sampling probabilities have played a central role in devising an efficient composite-likelihood method for estimating fine-scale recombination rates. Due to mathematical and computational challenges, these sampling probabilities are typically computed under the unrealistic assumption of a constant population size, and simulation studies have shown that resulting recombination rate estimates can be severely biased in certain cases of historical population size changes. To alleviate this problem, we develop here new methods to compute the sampling probability for variable population size functions that are piecewise constant. Our main theoretical result, implemented in a new software package called LDpop, is a novel formula for the sampling probability that can be evaluated by numerically exponentiating a large but sparse matrix. This formula can handle moderate sample sizes (n≤50) and demographic size histories with a large number of epochs (D≥64). In addition, LDpop implements an approximate formula for the sampling probability that is reasonably accurate and scales to hundreds in sample size (n≥256). Finally, LDpop includes an importance sampler for the posterior distribution of two-locus genealogies, based on a new result for the optimal proposal distribution in the variable-size setting. Using our methods, we study how a sharp population bottleneck followed by rapid growth affects the correlation between partially linked sites. Then, through an extensive simulation study, we show that accounting for population size changes under such a demographic model leads to substantial improvements in fine-scale recombination rate estimation." @default.
• W2964277555 created "2019-07-30" @default.
• W2964277555 creator A5015226637 @default.
• W2964277555 creator A5050837693 @default.
• W2964277555 creator A5071422010 @default.
• W2964277555 creator A5086930366 @default.
• W2964277555 date "2016-07-01" @default.
• W2964277555 modified "2023-10-06" @default.
• W2964277555 title "Two-Locus Likelihoods Under Variable Population Size and Fine-Scale Recombination Rate Estimation" @default.
• W2964277555 cites W114397555 @default.
• W2964277555 cites W1776889053 @default.
• W2964277555 cites W1928220195 @default.
• W2964277555 cites W1963756058 @default.
• W2964277555 cites W1967193543 @default.
• W2964277555 cites W1967686316 @default.
• W2964277555 cites W1968996982 @default.
• W2964277555 cites W1971112936 @default.
• W2964277555 cites W1978767356 @default.
• W2964277555 cites W1987882116 @default.
• W2964277555 cites W1999314404 @default.
• W2964277555 cites W2001707565 @default.
• W2964277555 cites W2005739865 @default.
• W2964277555 cites W2007052142 @default.
• W2964277555 cites W2013550946 @default.
• W2964277555 cites W2028212620 @default.
• W2964277555 cites W2029574650 @default.
• W2964277555 cites W2040640649 @default.
• W2964277555 cites W2042497384 @default.
• W2964277555 cites W2047657819 @default.
• W2964277555 cites W2056950361 @default.
• W2964277555 cites W2061551371 @default.
• W2964277555 cites W2067523861 @default.
• W2964277555 cites W2078482936 @default.
• W2964277555 cites W2084036993 @default.
• W2964277555 cites W2086160207 @default.
• W2964277555 cites W2091372342 @default.
• W2964277555 cites W2098862629 @default.
• W2964277555 cites W2107746932 @default.
• W2964277555 cites W2110407190 @default.
• W2964277555 cites W2111534865 @default.
• W2964277555 cites W2115476637 @default.
• W2964277555 cites W2117123843 @default.
• W2964277555 cites W2119279196 @default.
• W2964277555 cites W2125300654 @default.
• W2964277555 cites W2129454675 @default.
• W2964277555 cites W2130347285 @default.
• W2964277555 cites W2142417092 @default.
• W2964277555 cites W2146066805 @default.
• W2964277555 cites W2153149273 @default.
• W2964277555 cites W2153587490 @default.
• W2964277555 cites W2157751107 @default.
• W2964277555 cites W2164611608 @default.
• W2964277555 cites W2164785275 @default.
• W2964277555 cites W2165141658 @default.
• W2964277555 cites W2165601275 @default.
• W2964277555 cites W2171777347 @default.
• W2964277555 cites W2273451097 @default.
• W2964277555 cites W2283040147 @default.
• W2964277555 cites W3100505837 @default.
• W2964277555 cites W3102832675 @default.
• W2964277555 cites W4213279074 @default.
• W2964277555 cites W4252934295 @default.
• W2964277555 doi "https://doi.org/10.1534/genetics.115.184820" @default.
• W2964277555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4937484" @default.
• W2964277555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27182948" @default.
• W2964277555 hasPublicationYear "2016" @default.
• W2964277555 type Work @default.
• W2964277555 sameAs 2964277555 @default.
• W2964277555 citedByCount "54" @default.
• W2964277555 countsByYear W29642775552016 @default.
• W2964277555 countsByYear W29642775552017 @default.
• W2964277555 countsByYear W29642775552018 @default.
• W2964277555 countsByYear W29642775552019 @default.
• W2964277555 countsByYear W29642775552020 @default.
• W2964277555 countsByYear W29642775552021 @default.
• W2964277555 countsByYear W29642775552022 @default.
• W2964277555 countsByYear W29642775552023 @default.
• W2964277555 crossrefType "journal-article" @default.
• W2964277555 hasAuthorship W2964277555A5015226637 @default.
• W2964277555 hasAuthorship W2964277555A5050837693 @default.
• W2964277555 hasAuthorship W2964277555A5071422010 @default.
• W2964277555 hasAuthorship W2964277555A5086930366 @default.
• W2964277555 hasBestOaLocation W29642775551 @default.
• W2964277555 hasConcept C105795698 @default.
• W2964277555 hasConcept C106131492 @default.
• W2964277555 hasConcept C11413529 @default.
• W2964277555 hasConcept C129848803 @default.
• W2964277555 hasConcept C134306372 @default.
• W2964277555 hasConcept C140779682 @default.
• W2964277555 hasConcept C144024400 @default.
• W2964277555 hasConcept C149635348 @default.
• W2964277555 hasConcept C149923435 @default.
• W2964277555 hasConcept C164660894 @default.
• W2964277555 hasConcept C169733012 @default.
• W2964277555 hasConcept C182365436 @default.
• W2964277555 hasConcept C19499675 @default.
• W2964277555 hasConcept C199360897 @default.
• W2964277555 hasConcept C2777027219 @default.

• next