Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964290801> ?p ?o ?g. }
- W2964290801 endingPage "5408" @default.
- W2964290801 startingPage "5397" @default.
- W2964290801 abstract "Acinetobacter baumannii (A. baumannii) is an opportunistic pathogen that causes serious infections in the lungs, blood, and brain in critically ill hospital patients, resulting in considerable mortality rates every year. Due to the rapid appearance of multi-drug resistance or even pan-drug resistance isolates, it is becoming more and more difficult to cure A. baumannii infection by traditional antibiotic treatment, alternative strategies are urgently required to combat A. baumannii infection. In this study, we developed a DNA vaccine encoding two antigens from A. baumannii, OmpA and Pal, and the immunogenicity and protective efficacy was further evaluated. The results showed that the DNA vaccine exhibited significant immune protective efficacy against acute A. baumannii infection in a mouse pneumonia model, and cross protective efficacy was observed when immunized mice were challenged with clinical strains of A. baumannii. DNA vaccine immunization induced high level of humoral response and a mixed Th1/Th2/Th17 cellular response, which protect against lethal bacterial challenges by decreased bacterial loads and pathology in the lungs, and reduced level of inflammatory cytokines expression and inflammatory cell infiltration in BALF. These results demonstrated that it is possible to prevent A. baumannii infection by DNA vaccine and both OmpA and Pal could be serve as promising candidate antigens." @default.
- W2964290801 created "2019-07-30" @default.
- W2964290801 creator A5036970382 @default.
- W2964290801 creator A5049192510 @default.
- W2964290801 creator A5050676476 @default.
- W2964290801 creator A5051540373 @default.
- W2964290801 creator A5053583574 @default.
- W2964290801 creator A5054703440 @default.
- W2964290801 creator A5059689669 @default.
- W2964290801 creator A5064733360 @default.
- W2964290801 creator A5079640366 @default.
- W2964290801 date "2019-07-24" @default.
- W2964290801 modified "2023-10-14" @default.
- W2964290801 title "DNA vaccine encoding OmpA and Pal from Acinetobacter baumannii efficiently protects mice against pulmonary infection" @default.
- W2964290801 cites W1548493038 @default.
- W2964290801 cites W1579139345 @default.
- W2964290801 cites W1671878859 @default.
- W2964290801 cites W1672723208 @default.
- W2964290801 cites W1973149934 @default.
- W2964290801 cites W1991633654 @default.
- W2964290801 cites W1999563267 @default.
- W2964290801 cites W2002809077 @default.
- W2964290801 cites W2020268160 @default.
- W2964290801 cites W2025431751 @default.
- W2964290801 cites W2031438876 @default.
- W2964290801 cites W2038176331 @default.
- W2964290801 cites W2047365652 @default.
- W2964290801 cites W2047415047 @default.
- W2964290801 cites W2049347146 @default.
- W2964290801 cites W2052130550 @default.
- W2964290801 cites W2061236919 @default.
- W2964290801 cites W2065609478 @default.
- W2964290801 cites W2067379654 @default.
- W2964290801 cites W2068457130 @default.
- W2964290801 cites W2083657436 @default.
- W2964290801 cites W2084144197 @default.
- W2964290801 cites W2087435147 @default.
- W2964290801 cites W2090886777 @default.
- W2964290801 cites W2110223801 @default.
- W2964290801 cites W2118153832 @default.
- W2964290801 cites W2129379259 @default.
- W2964290801 cites W2135820651 @default.
- W2964290801 cites W2145248056 @default.
- W2964290801 cites W2159584001 @default.
- W2964290801 cites W2287470018 @default.
- W2964290801 cites W2343929593 @default.
- W2964290801 cites W2346152530 @default.
- W2964290801 cites W2347102183 @default.
- W2964290801 cites W2577883515 @default.
- W2964290801 cites W2612544238 @default.
- W2964290801 cites W2741262638 @default.
- W2964290801 cites W2760755023 @default.
- W2964290801 cites W2766097330 @default.
- W2964290801 cites W2766735640 @default.
- W2964290801 cites W2800896555 @default.
- W2964290801 cites W2811511919 @default.
- W2964290801 cites W2917055906 @default.
- W2964290801 cites W4322574849 @default.
- W2964290801 doi "https://doi.org/10.1007/s11033-019-04994-2" @default.
- W2964290801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31342294" @default.
- W2964290801 hasPublicationYear "2019" @default.
- W2964290801 type Work @default.
- W2964290801 sameAs 2964290801 @default.
- W2964290801 citedByCount "33" @default.
- W2964290801 countsByYear W29642908012020 @default.
- W2964290801 countsByYear W29642908012021 @default.
- W2964290801 countsByYear W29642908012022 @default.
- W2964290801 countsByYear W29642908012023 @default.
- W2964290801 crossrefType "journal-article" @default.
- W2964290801 hasAuthorship W2964290801A5036970382 @default.
- W2964290801 hasAuthorship W2964290801A5049192510 @default.
- W2964290801 hasAuthorship W2964290801A5050676476 @default.
- W2964290801 hasAuthorship W2964290801A5051540373 @default.
- W2964290801 hasAuthorship W2964290801A5053583574 @default.
- W2964290801 hasAuthorship W2964290801A5054703440 @default.
- W2964290801 hasAuthorship W2964290801A5059689669 @default.
- W2964290801 hasAuthorship W2964290801A5064733360 @default.
- W2964290801 hasAuthorship W2964290801A5079640366 @default.
- W2964290801 hasBestOaLocation W29642908011 @default.
- W2964290801 hasConcept C126322002 @default.
- W2964290801 hasConcept C147483822 @default.
- W2964290801 hasConcept C159047783 @default.
- W2964290801 hasConcept C167508917 @default.
- W2964290801 hasConcept C203014093 @default.
- W2964290801 hasConcept C2776315533 @default.
- W2964290801 hasConcept C2776460866 @default.
- W2964290801 hasConcept C2777637488 @default.
- W2964290801 hasConcept C2777914695 @default.
- W2964290801 hasConcept C2780801004 @default.
- W2964290801 hasConcept C2780868878 @default.
- W2964290801 hasConcept C501593827 @default.
- W2964290801 hasConcept C523546767 @default.
- W2964290801 hasConcept C54355233 @default.
- W2964290801 hasConcept C71924100 @default.
- W2964290801 hasConcept C86803240 @default.
- W2964290801 hasConcept C8891405 @default.
- W2964290801 hasConcept C89423630 @default.
- W2964290801 hasConceptScore W2964290801C126322002 @default.