FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964296427> ?p ?o ?g. }

• W2964296427 endingPage "101957" @default.
• W2964296427 startingPage "101957" @default.
• W2964296427 abstract "Abstract Objective We aimed to identify modularized structural atrophy of brain regions with a high degree of connectivity and its longitudinal changes associated with the progression of Alzheimer's disease (AD) using weighted gene co-expression network analysis (WGCNA), which is an unsupervised hierarchical clustering method originally used in genetic analysis. Methods We included participants with late mild cognitive impairment (MCI) at baseline from the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) study. We imputed normalized and Z-transformed structural volume or cortical thickness data of 164 parcellated brain regions/structures based on the calculations of the FreeSurfer software. We applied the WGCNA to extract modules with highly interconnected structural atrophic patterns and examined the correlation between the identified modules and clinical AD progression. Results We included 204 participants from the baseline dataset, and performed a follow-up with 100 in the 36-month dataset of MCI cohort participants from the J-ADNI. In the univariate correlation or variable importance analysis, baseline atrophy in temporal lobe regions/structures significantly predicted clinical AD progression. In the WGCNA consensus analysis, co-atrophy modules associated with MCI conversion were first distributed in the temporal lobe and subsequently extended to adjacent parietal cortical regions in the following 36 months. Conclusions We identified coordinated modules of brain atrophy and demonstrated their longitudinal extension along with the clinical course of AD progression using WGCNA, which showed a good correspondence with previous pathological studies of the tau propagation theory. Our results suggest the potential applicability of this methodology, originating from genetic analyses, for the surrogate visualization of the underlying pathological progression in neurodegenerative diseases not limited to AD." @default.
• W2964296427 created "2019-07-30" @default.
• W2964296427 creator A5005287215 @default.
• W2964296427 creator A5023346646 @default.
• W2964296427 creator A5023848866 @default.
• W2964296427 creator A5025241935 @default.
• W2964296427 creator A5035924543 @default.
• W2964296427 creator A5040101605 @default.
• W2964296427 creator A5042373488 @default.
• W2964296427 creator A5053907164 @default.
• W2964296427 creator A5060839417 @default.
• W2964296427 creator A5066539878 @default.
• W2964296427 creator A5074027917 @default.
• W2964296427 creator A5074331541 @default.
• W2964296427 creator A5082961488 @default.
• W2964296427 creator A5086245745 @default.
• W2964296427 creator A5089040841 @default.
• W2964296427 date "2019-01-01" @default.
• W2964296427 modified "2023-10-16" @default.
• W2964296427 title "Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis" @default.
• W2964296427 cites W1550111394 @default.
• W2964296427 cites W1831050183 @default.
• W2964296427 cites W1964305071 @default.
• W2964296427 cites W1964895626 @default.
• W2964296427 cites W1965173583 @default.
• W2964296427 cites W1966327575 @default.
• W2964296427 cites W1990792527 @default.
• W2964296427 cites W1993619996 @default.
• W2964296427 cites W1994694505 @default.
• W2964296427 cites W1999653836 @default.
• W2964296427 cites W2004185979 @default.
• W2964296427 cites W2008301592 @default.
• W2964296427 cites W2010283825 @default.
• W2964296427 cites W2011637489 @default.
• W2964296427 cites W2018852249 @default.
• W2964296427 cites W2035771001 @default.
• W2964296427 cites W2038003677 @default.
• W2964296427 cites W2052742260 @default.
• W2964296427 cites W2060705109 @default.
• W2964296427 cites W2063497316 @default.
• W2964296427 cites W2069762774 @default.
• W2964296427 cites W2070698988 @default.
• W2964296427 cites W2101135654 @default.
• W2964296427 cites W2108019246 @default.
• W2964296427 cites W2109434518 @default.
• W2964296427 cites W2119848633 @default.
• W2964296427 cites W2128422359 @default.
• W2964296427 cites W2155164847 @default.
• W2964296427 cites W2156220037 @default.
• W2964296427 cites W2159929956 @default.
• W2964296427 cites W2171380313 @default.
• W2964296427 cites W2171831801 @default.
• W2964296427 cites W2336932237 @default.
• W2964296427 cites W2559903050 @default.
• W2964296427 cites W2592119445 @default.
• W2964296427 cites W2750345052 @default.
• W2964296427 cites W2802655428 @default.
• W2964296427 cites W2884698159 @default.
• W2964296427 cites W2915608042 @default.
• W2964296427 cites W4241074797 @default.
• W2964296427 cites W4251087990 @default.
• W2964296427 doi "https://doi.org/10.1016/j.nicl.2019.101957" @default.
• W2964296427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6700430" @default.
• W2964296427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31400633" @default.
• W2964296427 hasPublicationYear "2019" @default.
• W2964296427 type Work @default.
• W2964296427 sameAs 2964296427 @default.
• W2964296427 citedByCount "9" @default.
• W2964296427 countsByYear W29642964272020 @default.
• W2964296427 countsByYear W29642964272021 @default.
• W2964296427 countsByYear W29642964272022 @default.
• W2964296427 crossrefType "journal-article" @default.
• W2964296427 hasAuthorship W2964296427A5005287215 @default.
• W2964296427 hasAuthorship W2964296427A5023346646 @default.
• W2964296427 hasAuthorship W2964296427A5023848866 @default.
• W2964296427 hasAuthorship W2964296427A5025241935 @default.
• W2964296427 hasAuthorship W2964296427A5035924543 @default.
• W2964296427 hasAuthorship W2964296427A5040101605 @default.
• W2964296427 hasAuthorship W2964296427A5042373488 @default.
• W2964296427 hasAuthorship W2964296427A5053907164 @default.
• W2964296427 hasAuthorship W2964296427A5060839417 @default.
• W2964296427 hasAuthorship W2964296427A5066539878 @default.
• W2964296427 hasAuthorship W2964296427A5074027917 @default.
• W2964296427 hasAuthorship W2964296427A5074331541 @default.
• W2964296427 hasAuthorship W2964296427A5082961488 @default.
• W2964296427 hasAuthorship W2964296427A5086245745 @default.
• W2964296427 hasAuthorship W2964296427A5089040841 @default.
• W2964296427 hasBestOaLocation W29642964271 @default.
• W2964296427 hasConcept C104317684 @default.
• W2964296427 hasConcept C142724271 @default.
• W2964296427 hasConcept C150194340 @default.
• W2964296427 hasConcept C169760540 @default.
• W2964296427 hasConcept C199360897 @default.
• W2964296427 hasConcept C2779134260 @default.
• W2964296427 hasConcept C2781172350 @default.
• W2964296427 hasConcept C41008148 @default.
• W2964296427 hasConcept C54355233 @default.
• W2964296427 hasConcept C70721500 @default.

• next