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- W2964304883 abstract "To assess the effects of 4-nitrophenol (PNP) and 3-methyl-4-nitrophenol (PNMC) on steroidogenesis in the chicken ovary, white (WF, 1–4 mm) and yellowish (YF, 4–8 mm) prehierarchical follicles were incubated in a medium supplemented with PNP or PNMC (10−8–10−4 M), ovine LH (oLH; 10 ng/mL), and combinations of oLH with PNP or PNMC (10−6 M). Testosterone (T) and estradiol (E2) concentrations in media and mRNA expression for steroidogenic proteins (STAR, HSD3B1, and CYP19A1), and LH receptors (LHR), estrogen receptor α (ESR1) and β (ESR2) in follicles were determined by RIA and real-time qPCR, respectively. PNP and PNMC decreased T and E2 secretion by the WF and YF, and oLH-stimulated T secretion from these follicles. PNP decreased basal STAR and HSD3B1 mRNA levels both in the WF and YF, and CYP19A1 mRNAs in the WF. PNP reduced oLH-affected mRNA expression of these genes in the YF. PNMC inhibited basal STAR, HSD3B1, and CYP19A1 mRNA expression in the WF, but not in the YF. PNMC reduced oLH-stimulated STAR and CYP19A1 expression in the YF and WF, respectively. PNP decreased basal mRNA expression of LHR, ESR1, and ESR2 in the WF, but it increased ESR1 and ESR2 mRNA levels in the YF. PNMC reduced both basal and oLH-affected LHR, ESR1, and ESR2 mRNA expression in the WF; however, it did not influence expression of these genes in the YF. We suggest that nitrophenols by influencing sex steroid synthesis and transcription of LH and estrogen receptors in prehierarchical ovarian follicles may impair their development and selection to the preovulatory hierarchy." @default.
- W2964304883 created "2019-07-30" @default.
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- W2964304883 date "2020-01-01" @default.
- W2964304883 modified "2023-10-15" @default.
- W2964304883 title "Nitrophenols suppress steroidogenesis in prehierarchical chicken ovarian follicles by targeting STAR, HSD3B1, and CYP19A1 and downregulating LH and estrogen receptor expression" @default.
- W2964304883 cites W1973326832 @default.
- W2964304883 cites W1976701301 @default.
- W2964304883 cites W1981421083 @default.
- W2964304883 cites W1984929402 @default.
- W2964304883 cites W1992802919 @default.
- W2964304883 cites W1999721200 @default.
- W2964304883 cites W2004481345 @default.
- W2964304883 cites W2011896362 @default.
- W2964304883 cites W2013985800 @default.
- W2964304883 cites W2015242644 @default.
- W2964304883 cites W2017193695 @default.
- W2964304883 cites W2018843106 @default.
- W2964304883 cites W2024238204 @default.
- W2964304883 cites W2027093008 @default.
- W2964304883 cites W2048156664 @default.
- W2964304883 cites W2048519925 @default.
- W2964304883 cites W2051545938 @default.
- W2964304883 cites W2057365117 @default.
- W2964304883 cites W2060376740 @default.
- W2964304883 cites W2064241974 @default.
- W2964304883 cites W2065486110 @default.
- W2964304883 cites W2067504916 @default.
- W2964304883 cites W2068148253 @default.
- W2964304883 cites W2072107053 @default.
- W2964304883 cites W2073689765 @default.
- W2964304883 cites W2075722831 @default.
- W2964304883 cites W2088615962 @default.
- W2964304883 cites W2088987164 @default.
- W2964304883 cites W2089488131 @default.
- W2964304883 cites W2090213446 @default.
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- W2964304883 cites W2109347638 @default.
- W2964304883 cites W2113705043 @default.
- W2964304883 cites W2114570899 @default.
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- W2964304883 cites W2132211184 @default.
- W2964304883 cites W2132824713 @default.
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- W2964304883 cites W2144514632 @default.
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- W2964304883 cites W2263843920 @default.
- W2964304883 cites W2270599957 @default.
- W2964304883 cites W2353599515 @default.
- W2964304883 cites W253395028 @default.
- W2964304883 cites W2553614830 @default.
- W2964304883 cites W2571311053 @default.
- W2964304883 cites W2599112801 @default.
- W2964304883 cites W2606862900 @default.
- W2964304883 cites W2617306549 @default.
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- W2964304883 cites W2756086301 @default.
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- W2964304883 doi "https://doi.org/10.1016/j.domaniend.2019.07.006" @default.
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