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• W2964347726 abstract "We herein report the case of a 2‐year‐old girl with neurofibromatosis type 1 (NF1), who presented with a 12‐cm mass in the right retroperitoneum and underwent tumor resection. Histologically, the tumor was composed of two distinct components: one was teratoma, showing mature morphology; and the other was embryonal rhabdomyosarcoma. An interphase fluorescence in situ hybridization (FISH) analysis of the rhabdomyosarcoma component revealed the absence of isochromosome 12p. Although it is well known that rhabdomyosarcoma occurs in infantile NF1, and that rhabdomyosarcoma can arise from teratoma as a somatic‐type malignancy, to the best of our knowledge, this is the first case of an infantile NF1 patient, who developed rhabdomyosarcoma within a retroperitoneal teratoma. The absence of chromosome 12p alteration suggests a possibility that the rhabdomyosarcoma occurred due to the NF1 background, not as a somatic‐type malignancy of germ cell tumor." @default.
• W2964347726 created "2019-07-30" @default.
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• W2964347726 date "2019-07-21" @default.
• W2964347726 modified "2023-10-12" @default.
• W2964347726 title "Rhabdomyosarcoma arising from retroperitoneal teratoma in an infantile neurofibromatosis type 1 patient" @default.
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• W2964347726 doi "https://doi.org/10.1111/pin.12810" @default.
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