Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964351569> ?p ?o ?g. }
- W2964351569 endingPage "16550" @default.
- W2964351569 startingPage "16541" @default.
- W2964351569 abstract "Non-Hodgkin lymphomas (NHLs) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely up-regulated in different NHL subtypes. Using multiplexed inhibitor bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely up-regulated and important for cell survival in primary effusion lymphoma (PEL), which is a viral lymphoma infected with Kaposi’s sarcoma-associated herpesvirus (KSHV). Tyro3 was also highly expressed in PEL cell lines as well as in primary PEL exudates. Based on this discovery, we developed an inhibitor against Tyro3 named UNC3810A, which hindered cell growth in PEL, but not in other NHL subtypes where Tyro3 was not highly expressed. UNC3810A also significantly inhibited tumor progression in a PEL xenograft mouse model that was not seen in a non-PEL NHL model. Taken together, our data suggest Tyro3 is a therapeutic target for PEL." @default.
- W2964351569 created "2019-07-30" @default.
- W2964351569 creator A5000707607 @default.
- W2964351569 creator A5018485741 @default.
- W2964351569 creator A5020565504 @default.
- W2964351569 creator A5021245679 @default.
- W2964351569 creator A5021975754 @default.
- W2964351569 creator A5027188499 @default.
- W2964351569 creator A5033923298 @default.
- W2964351569 creator A5038884141 @default.
- W2964351569 creator A5040205022 @default.
- W2964351569 creator A5041987464 @default.
- W2964351569 creator A5047612906 @default.
- W2964351569 creator A5049715475 @default.
- W2964351569 creator A5070252326 @default.
- W2964351569 creator A5078770033 @default.
- W2964351569 creator A5085566380 @default.
- W2964351569 date "2019-07-25" @default.
- W2964351569 modified "2023-10-10" @default.
- W2964351569 title "Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma" @default.
- W2964351569 cites W106947309 @default.
- W2964351569 cites W128313406 @default.
- W2964351569 cites W1486753210 @default.
- W2964351569 cites W1499349338 @default.
- W2964351569 cites W1607701774 @default.
- W2964351569 cites W1966938583 @default.
- W2964351569 cites W1968525093 @default.
- W2964351569 cites W1972073735 @default.
- W2964351569 cites W1973159288 @default.
- W2964351569 cites W1973773204 @default.
- W2964351569 cites W1974756622 @default.
- W2964351569 cites W1995153837 @default.
- W2964351569 cites W2020639372 @default.
- W2964351569 cites W2021020413 @default.
- W2964351569 cites W2023003896 @default.
- W2964351569 cites W2028959752 @default.
- W2964351569 cites W2033898924 @default.
- W2964351569 cites W2034611537 @default.
- W2964351569 cites W2041702048 @default.
- W2964351569 cites W2044962700 @default.
- W2964351569 cites W2045608879 @default.
- W2964351569 cites W2067872596 @default.
- W2964351569 cites W2069411231 @default.
- W2964351569 cites W2083870593 @default.
- W2964351569 cites W2084086052 @default.
- W2964351569 cites W2084232727 @default.
- W2964351569 cites W2085768679 @default.
- W2964351569 cites W2087618935 @default.
- W2964351569 cites W2089166545 @default.
- W2964351569 cites W2090026828 @default.
- W2964351569 cites W2092412372 @default.
- W2964351569 cites W2099904968 @default.
- W2964351569 cites W2100139245 @default.
- W2964351569 cites W2104775266 @default.
- W2964351569 cites W2109736752 @default.
- W2964351569 cites W2123145623 @default.
- W2964351569 cites W2133902177 @default.
- W2964351569 cites W2135581618 @default.
- W2964351569 cites W2137145604 @default.
- W2964351569 cites W2139365621 @default.
- W2964351569 cites W2144970247 @default.
- W2964351569 cites W2147246240 @default.
- W2964351569 cites W2150903105 @default.
- W2964351569 cites W2151911795 @default.
- W2964351569 cites W2154191201 @default.
- W2964351569 cites W2155231833 @default.
- W2964351569 cites W2162550834 @default.
- W2964351569 cites W2165575701 @default.
- W2964351569 cites W2172208779 @default.
- W2964351569 cites W2177466111 @default.
- W2964351569 cites W2178557128 @default.
- W2964351569 cites W2194246005 @default.
- W2964351569 cites W2279120117 @default.
- W2964351569 cites W2280998731 @default.
- W2964351569 cites W2286498994 @default.
- W2964351569 cites W2332991185 @default.
- W2964351569 cites W2335778697 @default.
- W2964351569 cites W2336241188 @default.
- W2964351569 cites W2340246725 @default.
- W2964351569 cites W2346898981 @default.
- W2964351569 cites W2413667427 @default.
- W2964351569 cites W2424995076 @default.
- W2964351569 cites W2477177044 @default.
- W2964351569 cites W2507710860 @default.
- W2964351569 cites W2510291743 @default.
- W2964351569 cites W2516701701 @default.
- W2964351569 cites W2518488421 @default.
- W2964351569 cites W2568166803 @default.
- W2964351569 cites W2765432370 @default.
- W2964351569 cites W2787520936 @default.
- W2964351569 cites W2789812443 @default.
- W2964351569 cites W2797213947 @default.
- W2964351569 cites W2806899580 @default.
- W2964351569 cites W4241443461 @default.
- W2964351569 cites W973171548 @default.
- W2964351569 doi "https://doi.org/10.1073/pnas.1903991116" @default.
- W2964351569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6697815" @default.
- W2964351569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31346082" @default.