Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964360901> ?p ?o ?g. }
- W2964360901 abstract "Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs which cause tissue damage and may promote tumorigenesis. To manage that disorder, free iron depletion can be induced by iron chelators like deferoxamine which are gaining interest also in the cancer field since iron stock could be a potent target for managing tumorigenesis. Curcumin, a well-known active substance extracted from the turmeric rhizome, has shown to be destabilizing endoplasmic reticulum and secondarily lysozomes, increasing mitophagy/autophagy and subsequent apoptosis. Recent findings show that cells treated with curcumin exhibit also a decrease in ferritin, which is consistent with it’s chemical structure and iron chelating activity. Here we investigated how curcumin would play on the intracellular effects of iron overload via Fe-Nitriloacetic acid or Ferric ammonium citrate loading in Huh-7 cells and explore consequences in terms of antioxidant activity, autophagy, or apoptotic signal transduction. With T51B and RL-34 epithelial cells experiments, we brought evidence that curcumin-iron complexation abolishes both curcumin-induced autophagy and apoptosis together with the tumorigenic action of iron overload." @default.
- W2964360901 created "2019-08-13" @default.
- W2964360901 creator A5009314699 @default.
- W2964360901 creator A5011496439 @default.
- W2964360901 creator A5065937966 @default.
- W2964360901 creator A5071519269 @default.
- W2964360901 creator A5085509520 @default.
- W2964360901 creator A5090025410 @default.
- W2964360901 date "2019-08-02" @default.
- W2964360901 modified "2023-10-01" @default.
- W2964360901 title "Iron chelation by curcumin suppress both curcumin-induced autoghagy and cell death together with iron overload neoplastic transformation" @default.
- W2964360901 cites W1508340483 @default.
- W2964360901 cites W1577909840 @default.
- W2964360901 cites W1588526262 @default.
- W2964360901 cites W1768446746 @default.
- W2964360901 cites W1965881217 @default.
- W2964360901 cites W1968052682 @default.
- W2964360901 cites W1969257164 @default.
- W2964360901 cites W1969712626 @default.
- W2964360901 cites W1974061668 @default.
- W2964360901 cites W1975668168 @default.
- W2964360901 cites W1975770667 @default.
- W2964360901 cites W1977191081 @default.
- W2964360901 cites W1983395500 @default.
- W2964360901 cites W1984353977 @default.
- W2964360901 cites W1985935892 @default.
- W2964360901 cites W1990437598 @default.
- W2964360901 cites W1996826201 @default.
- W2964360901 cites W1997183854 @default.
- W2964360901 cites W2001041922 @default.
- W2964360901 cites W2006250045 @default.
- W2964360901 cites W2007172016 @default.
- W2964360901 cites W2011657572 @default.
- W2964360901 cites W2016274911 @default.
- W2964360901 cites W2017350478 @default.
- W2964360901 cites W2021711019 @default.
- W2964360901 cites W2022708198 @default.
- W2964360901 cites W2034669172 @default.
- W2964360901 cites W2037645162 @default.
- W2964360901 cites W2044627978 @default.
- W2964360901 cites W2045122835 @default.
- W2964360901 cites W2048138350 @default.
- W2964360901 cites W2054662394 @default.
- W2964360901 cites W2056539232 @default.
- W2964360901 cites W2059491360 @default.
- W2964360901 cites W2062927875 @default.
- W2964360901 cites W2070135211 @default.
- W2964360901 cites W2071434358 @default.
- W2964360901 cites W2073471620 @default.
- W2964360901 cites W2077166822 @default.
- W2964360901 cites W2101575450 @default.
- W2964360901 cites W2105988137 @default.
- W2964360901 cites W2109968053 @default.
- W2964360901 cites W2112027230 @default.
- W2964360901 cites W2116046043 @default.
- W2964360901 cites W2120709879 @default.
- W2964360901 cites W2124471593 @default.
- W2964360901 cites W2124513795 @default.
- W2964360901 cites W2133291429 @default.
- W2964360901 cites W2140665078 @default.
- W2964360901 cites W2145136975 @default.
- W2964360901 cites W2147965104 @default.
- W2964360901 cites W2148731081 @default.
- W2964360901 cites W2150579866 @default.
- W2964360901 cites W2161658362 @default.
- W2964360901 cites W2171559922 @default.
- W2964360901 cites W2185048956 @default.
- W2964360901 cites W2234070446 @default.
- W2964360901 cites W2238003553 @default.
- W2964360901 cites W2269134064 @default.
- W2964360901 cites W2329510256 @default.
- W2964360901 cites W2500763735 @default.
- W2964360901 cites W2509899889 @default.
- W2964360901 cites W2512883334 @default.
- W2964360901 cites W2521425438 @default.
- W2964360901 cites W2581634828 @default.
- W2964360901 cites W2757047184 @default.
- W2964360901 cites W2762087180 @default.
- W2964360901 cites W2770709665 @default.
- W2964360901 cites W2899876893 @default.
- W2964360901 cites W2903234309 @default.
- W2964360901 cites W4253825009 @default.
- W2964360901 doi "https://doi.org/10.1101/722942" @default.
- W2964360901 hasPublicationYear "2019" @default.
- W2964360901 type Work @default.
- W2964360901 sameAs 2964360901 @default.
- W2964360901 citedByCount "1" @default.
- W2964360901 countsByYear W29643609012021 @default.
- W2964360901 crossrefType "posted-content" @default.
- W2964360901 hasAuthorship W2964360901A5009314699 @default.
- W2964360901 hasAuthorship W2964360901A5011496439 @default.
- W2964360901 hasAuthorship W2964360901A5065937966 @default.
- W2964360901 hasAuthorship W2964360901A5071519269 @default.
- W2964360901 hasAuthorship W2964360901A5085509520 @default.
- W2964360901 hasAuthorship W2964360901A5090025410 @default.
- W2964360901 hasBestOaLocation W29643609011 @default.
- W2964360901 hasConcept C104317684 @default.
- W2964360901 hasConcept C178790620 @default.
- W2964360901 hasConcept C185592680 @default.
- W2964360901 hasConcept C190283241 @default.