Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964381950> ?p ?o ?g. }
- W2964381950 endingPage "1779" @default.
- W2964381950 startingPage "1769" @default.
- W2964381950 abstract "Abstract Objectives This study aimed to investigate the role of JAK2‐STAT3 (Janus kinase 2/signal transducer and activator of transcription 3) in periapical disease caused by Enterococcus faecalis , as well as the correlation between lipoteichoic acid (LTA) in E. faecalis and the activity of the JAK2‐STAT3 signaling pathway and osteoclast formation. Materials and Methods A rat model of periapical periodontitis induced by E. faecalis was established. Periapical bone resorption was confirmed by HE staining. The expression of JAK2, p‐JAK2, STAT3, and p‐STAT3 was assessed with immunohistochemical staining. Osteoclasts were observed through enzyme histochemical staining. LTA acted on mouse osteoclast precursor cells (RAW264.7 cells); a JAK2 inhibitor (AG490) was used to inhibit the JAK2‐STAT3 pathway in RAW264.7 cells. The expression of proteins in the JAK2‐STAT3 pathway and TRAP (tartrate resistant acid phosphatase) in RAW264.7 cells was also detected. Results Rat periapical periodontitis was successfully established and bone resorption peaked at day 21. The expression of critical components in the JAK2‐STAT3 pathway increased with the progression of inflammation. LTA promoted the differentiation of RAW264.7 cells into osteoclasts. NFATc1 was highly expressed and was inhibited by AG490. Conclusions JAK2‐STAT3 signaling pathway plays an important role in the process of periapical bone resorption and osteoclastogenesis." @default.
- W2964381950 created "2019-08-13" @default.
- W2964381950 creator A5010698345 @default.
- W2964381950 creator A5021138454 @default.
- W2964381950 creator A5042947574 @default.
- W2964381950 creator A5043311357 @default.
- W2964381950 creator A5063889519 @default.
- W2964381950 creator A5072709319 @default.
- W2964381950 creator A5082543297 @default.
- W2964381950 date "2019-08-19" @default.
- W2964381950 modified "2023-09-28" @default.
- W2964381950 title "JAK2‐STAT3 signaling pathway is involved in rat periapical lesions induced by <i>Enterococcus faecalis</i>" @default.
- W2964381950 cites W1583617236 @default.
- W2964381950 cites W1833836391 @default.
- W2964381950 cites W1894169931 @default.
- W2964381950 cites W1943276336 @default.
- W2964381950 cites W1976046665 @default.
- W2964381950 cites W1990714462 @default.
- W2964381950 cites W2001628786 @default.
- W2964381950 cites W2015009800 @default.
- W2964381950 cites W2024596121 @default.
- W2964381950 cites W2030966015 @default.
- W2964381950 cites W2036971698 @default.
- W2964381950 cites W2066960433 @default.
- W2964381950 cites W2071841086 @default.
- W2964381950 cites W2084130767 @default.
- W2964381950 cites W2090145292 @default.
- W2964381950 cites W2095861062 @default.
- W2964381950 cites W2098136696 @default.
- W2964381950 cites W2101331960 @default.
- W2964381950 cites W2111663933 @default.
- W2964381950 cites W2112125142 @default.
- W2964381950 cites W2116339132 @default.
- W2964381950 cites W2138609584 @default.
- W2964381950 cites W2139707375 @default.
- W2964381950 cites W2153869151 @default.
- W2964381950 cites W2175060709 @default.
- W2964381950 cites W2226530634 @default.
- W2964381950 cites W2250685791 @default.
- W2964381950 cites W2276544418 @default.
- W2964381950 cites W2327674407 @default.
- W2964381950 cites W2397909996 @default.
- W2964381950 cites W2431941148 @default.
- W2964381950 cites W2512695119 @default.
- W2964381950 cites W2513024123 @default.
- W2964381950 cites W2565208283 @default.
- W2964381950 cites W2590690481 @default.
- W2964381950 cites W2593097029 @default.
- W2964381950 cites W2767444248 @default.
- W2964381950 cites W2767478133 @default.
- W2964381950 doi "https://doi.org/10.1111/odi.13169" @default.
- W2964381950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31365165" @default.
- W2964381950 hasPublicationYear "2019" @default.
- W2964381950 type Work @default.
- W2964381950 sameAs 2964381950 @default.
- W2964381950 citedByCount "8" @default.
- W2964381950 countsByYear W29643819502020 @default.
- W2964381950 countsByYear W29643819502021 @default.
- W2964381950 countsByYear W29643819502022 @default.
- W2964381950 countsByYear W29643819502023 @default.
- W2964381950 crossrefType "journal-article" @default.
- W2964381950 hasAuthorship W2964381950A5010698345 @default.
- W2964381950 hasAuthorship W2964381950A5021138454 @default.
- W2964381950 hasAuthorship W2964381950A5042947574 @default.
- W2964381950 hasAuthorship W2964381950A5043311357 @default.
- W2964381950 hasAuthorship W2964381950A5063889519 @default.
- W2964381950 hasAuthorship W2964381950A5072709319 @default.
- W2964381950 hasAuthorship W2964381950A5082543297 @default.
- W2964381950 hasConcept C104317684 @default.
- W2964381950 hasConcept C126322002 @default.
- W2964381950 hasConcept C142724271 @default.
- W2964381950 hasConcept C170493617 @default.
- W2964381950 hasConcept C171958077 @default.
- W2964381950 hasConcept C180675623 @default.
- W2964381950 hasConcept C181199279 @default.
- W2964381950 hasConcept C185592680 @default.
- W2964381950 hasConcept C21547065 @default.
- W2964381950 hasConcept C2776033226 @default.
- W2964381950 hasConcept C2778923194 @default.
- W2964381950 hasConcept C2779489039 @default.
- W2964381950 hasConcept C2779895986 @default.
- W2964381950 hasConcept C2780385504 @default.
- W2964381950 hasConcept C523546767 @default.
- W2964381950 hasConcept C54355233 @default.
- W2964381950 hasConcept C547475151 @default.
- W2964381950 hasConcept C55493867 @default.
- W2964381950 hasConcept C62478195 @default.
- W2964381950 hasConcept C673006 @default.
- W2964381950 hasConcept C6977687 @default.
- W2964381950 hasConcept C71924100 @default.
- W2964381950 hasConcept C74864618 @default.
- W2964381950 hasConcept C86803240 @default.
- W2964381950 hasConceptScore W2964381950C104317684 @default.
- W2964381950 hasConceptScore W2964381950C126322002 @default.
- W2964381950 hasConceptScore W2964381950C142724271 @default.
- W2964381950 hasConceptScore W2964381950C170493617 @default.
- W2964381950 hasConceptScore W2964381950C171958077 @default.
- W2964381950 hasConceptScore W2964381950C180675623 @default.