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- W2964392743 endingPage "107394" @default.
- W2964392743 startingPage "107394" @default.
- W2964392743 abstract "Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly increased by various inflammatory and immunological conditions, including rheumatoid arthritis, multiple sclerosis, Alzheimer’s disease, and several cancers. However, its physiological and pathophysiological roles in the development of cancer and neurodegenerative and inflammatory diseases remain unclear. Several studies have reported that CHI3L1 promotes cancer proliferation, inflammatory cytokine production, and microglial activation, and that multiple receptors, such as advanced glycation end product, syndecan-1/αVβ3, and IL-13Rα2, are involved. In addition, the pro-inflammatory action of CHI3L1 may be mediated via the protein kinase B and phosphoinositide-3 signaling pathways and responses to various pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Therefore, CHI3L1 could contribute to a vast array of inflammatory diseases. In this article, we review recent findings regarding the roles of CHI3L1 and suggest therapeutic approaches targeting CHI3L1 in the development of cancers, neurodegenerative diseases, and inflammatory diseases." @default.
- W2964392743 created "2019-08-13" @default.
- W2964392743 creator A5007610160 @default.
- W2964392743 creator A5037204409 @default.
- W2964392743 creator A5044024396 @default.
- W2964392743 creator A5087838333 @default.
- W2964392743 creator A5088567252 @default.
- W2964392743 date "2019-11-01" @default.
- W2964392743 modified "2023-10-16" @default.
- W2964392743 title "Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases" @default.
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